| SP | Zambrano, C.Zambrano, Carlos >> | 24 | 2005 | R | 92 | 12 | 12 | 6 | 4 | 2.91 | .279 | 1.13 | 7.1 | 3.1 | 7.8 | 89.2 | 70 | 30 | 29 | 8 | 31 | 77 | 1 | 0 | 0 | 0 | 10 | 3 | 4 | 3.58 |
| SP | Millwood, K.Millwood, Kevin >> | 31 | 2005 | R | 73 | 11 | 11 | 4 | 4 | 7.32 | .396 | 1.92 | 12.9 | 4.4 | 5.2 | 55.1 | 79 | 51 | 45 | 12 | 27 | 32 | 0 | 0 | 0 | 0 | 2 | 3 | 0 | 6.31 |
| SP | Davis, D.Davis, Doug # >> | 30 | 2005 | L | 65 | 11 | 11 | 5 | 3 | 5.37 | .344 | 1.54 | 10.6 | 3.4 | 7.3 | 68.2 | 80 | 43 | 41 | 10 | 26 | 55 | 0 | 0 | 0 | 0 | 3 | 2 | 2 | 4.53 |
| SP | Schmidt, J.Schmidt, Jason >> | 32 | 2005 | R | 40 | 11 | 11 | 3 | 3 | 6.75 | .374 | 1.73 | 9.8 | 5.8 | 5.6 | 48.0 | 52 | 36 | 36 | 4 | 31 | 30 | 0 | 0 | 0 | 0 | 0 | 3 | 1 | 4.96 |
| SP | Cabrera, D.Cabrera, Daniel >> | 24 | 2005 | R | 44 | 11 | 11 | 6 | 3 | 4.45 | .328 | 1.43 | 8.2 | 4.8 | 9.3 | 58.2 | 53 | 29 | 29 | 9 | 31 | 60 | 1 | 0 | 0 | 1 | 4 | 2 | 5 | 4.66 |
| RP | Hensley, C.Hensley, Clay >> | 26 | 2005 | R | 80 | 29 | 0 | 2 | 1 | 2.97 | .267 | 1.04 | 5.8 | 3.7 | 6.7 | 39.1 | 25 | 14 | 13 | 2 | 16 | 29 | 0 | 1 | 3 | 0 | 0 | 2 | 0 | 3.56 |
| RP | Hermanson, D.Hermanson, Dustin >> | 33 | 2005 | R | 69 | 23 | 0 | 2 | 0 | 6.23 | .361 | 1.69 | 11.8 | 3.5 | 4.5 | 26.0 | 34 | 18 | 18 | 4 | 10 | 13 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 5.15 |
| RP | Calero, K.Calero, Kiko >> | 30 | 2005 | R | 68 | 20 | 0 | 2 | 1 | 4.07 | .291 | 1.19 | 7.9 | 3.0 | 6.0 | 24.1 | 21 | 11 | 11 | 4 | 8 | 16 | 0 | 0 | 3 | 0 | 0 | 1 | 2 | 4.96 |
| RP | Hammond, C.Hammond, Chris >> | 39 | 2005 | L | 60 | 12 | 0 | 1 | 0 | 0.68 | .167 | 0.60 | 2.1 | 3.5 | 6.9 | 13.1 | 3 | 1 | 1 | 0 | 5 | 10 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.62 |
| RP | Witasick, J.Witasick, Jay >> | 33 | 2005 | R | 52 | 14 | 0 | 1 | 0 | 3.12 | .288 | 1.15 | 6.9 | 3.7 | 9.0 | 17.1 | 13 | 6 | 6 | 3 | 7 | 17 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 4.71 |
| CL | Rivera, M.Rivera, Mariano $ >> | 36 | 2005 | R | 99 | 26 | 0 | 2 | 2 | 2.28 | .224 | 0.87 | 5.7 | 2.3 | 9.3 | 27.2 | 17 | 7 | 7 | 0 | 7 | 28 | 0 | 15 | 0 | 0 | 0 | 0 | 0 | 1.70 |