| SP | Harden, R.Harden, Rich >> | 24 | 2005 | R | 96 | 22 | 22 | 10 | 8 | 3.87 | .325 | 1.41 | 9.0 | 3.7 | 6.5 | 135.0 | 135 | 59 | 58 | 10 | 55 | 98 | 0 | 0 | 0 | 0 | 13 | 5 | 6 | 3.84 |
| SP | Burnett, A.Burnett, A.J. >> | 28 | 2005 | R | 76 | 21 | 21 | 8 | 9 | 6.45 | .378 | 1.76 | 11.1 | 4.9 | 6.8 | 111.2 | 137 | 81 | 80 | 9 | 60 | 84 | 0 | 0 | 0 | 0 | 7 | 7 | 7 | 4.35 |
| SP | Buehrle, M.Buehrle, Mark >> | 26 | 2005 | L | 68 | 21 | 21 | 9 | 5 | 4.99 | .324 | 1.43 | 10.3 | 2.6 | 7.1 | 137.0 | 157 | 76 | 76 | 18 | 39 | 108 | 4 | 0 | 0 | 1 | 9 | 1 | 2 | 4.01 |
| SP | Benson, K.Benson, Kris # >> | 31 | 2005 | R | 53 | 22 | 21 | 8 | 4 | 5.24 | .345 | 1.52 | 10.2 | 3.6 | 4.5 | 125.1 | 141 | 76 | 73 | 17 | 50 | 62 | 1 | 0 | 0 | 0 | 12 | 7 | 2 | 5.14 |
| SP | Schmidt, J.Schmidt, Jason >> | 32 | 2005 | R | 40 | 23 | 20 | 7 | 8 | 5.21 | .333 | 1.47 | 8.8 | 4.5 | 6.8 | 114.0 | 111 | 69 | 66 | 13 | 57 | 86 | 0 | 0 | 0 | 0 | 10 | 3 | 4 | 4.55 |
| RP | Rivera, M.Rivera, Mariano >> | 36 | 2005 | R | 99 | 59 | 0 | 5 | 2 | 4.40 | .313 | 1.33 | 8.2 | 3.8 | 9.9 | 88.0 | 80 | 45 | 43 | 7 | 37 | 97 | 0 | 5 | 2 | 0 | 0 | 3 | 0 | 3.19 |
| RP | Rhodes, A.Rhodes, Arthur >> | 36 | 2005 | L | 87 | 57 | 0 | 2 | 6 | 2.48 | .268 | 1.06 | 7.1 | 2.5 | 8.7 | 80.0 | 63 | 24 | 22 | 3 | 22 | 77 | 0 | 8 | 0 | 0 | 0 | 3 | 0 | 2.50 |
| RP | Betancourt, R.Betancourt, Rafael >> | 30 | 2005 | R | 74 | 43 | 0 | 5 | 1 | 2.24 | .252 | 0.99 | 6.9 | 2.1 | 8.6 | 60.1 | 46 | 15 | 15 | 4 | 14 | 57 | 0 | 5 | 1 | 0 | 0 | 1 | 0 | 2.72 |
| RP | Benoit, J.Benoit, Joaquin >> | 28 | 2005 | R | 61 | 40 | 0 | 5 | 2 | 5.05 | .332 | 1.44 | 9.6 | 3.5 | 5.8 | 62.1 | 66 | 35 | 35 | 7 | 24 | 40 | 0 | 5 | 1 | 0 | 0 | 3 | 1 | 4.48 |
| RP | Hernandez, R.Hernandez, Roberto >> | 41 | 2005 | R | 56 | 27 | 0 | 0 | 1 | 3.75 | .321 | 1.39 | 8.8 | 3.8 | 6.5 | 36.0 | 35 | 17 | 15 | 2 | 15 | 26 | 0 | 1 | 1 | 0 | 0 | 1 | 4 | 3.61 |