| SP | Zambrano, C.Zambrano, Carlos >> | 24 | 2005 | R | 92 | 24 | 24 | 9 | 10 | 5.83 | .351 | 1.57 | 9.3 | 4.9 | 5.9 | 142.0 | 146 | 94 | 92 | 22 | 77 | 93 | 2 | 0 | 0 | 0 | 8 | 7 | 2 | 5.48 |
| SP | Myers, B.Myers, Brett # >> | 25 | 2005 | R | 81 | 23 | 23 | 12 | 4 | 3.88 | .300 | 1.24 | 8.4 | 2.8 | 8.4 | 144.0 | 134 | 62 | 62 | 12 | 45 | 134 | 0 | 0 | 0 | 0 | 14 | 6 | 0 | 3.28 |
| SP | Sabathia, C.Sabathia, CC >> | 25 | 2005 | L | 66 | 22 | 22 | 10 | 4 | 4.48 | .313 | 1.30 | 9.4 | 2.4 | 6.3 | 136.2 | 142 | 70 | 68 | 15 | 36 | 95 | 0 | 0 | 0 | 0 | 12 | 9 | 2 | 4.03 |
| RP | Carrasco, H.Carrasco, Hector >> | 36 | 2005 | R | 83 | 62 | 0 | 4 | 3 | 5.58 | .320 | 1.40 | 8.3 | 4.4 | 6.1 | 80.2 | 74 | 50 | 50 | 13 | 39 | 54 | 0 | 2 | 7 | 0 | 0 | 1 | 1 | 5.26 |
| RP | Hensley, C.Hensley, Clay † >> | 26 | 2005 | R | 80 | 54 | 0 | 5 | 2 | 2.51 | .297 | 1.26 | 7.3 | 4.1 | 5.7 | 68.0 | 55 | 19 | 19 | 5 | 31 | 43 | 0 | 2 | 1 | 0 | 0 | 0 | 4 | 4.06 |
| RP | Thompson, B.Thompson, Brad >> | 23 | 2005 | R | 66 | 31 | 0 | 3 | 0 | 3.89 | .311 | 1.32 | 9.2 | 2.7 | 5.6 | 37.0 | 38 | 16 | 16 | 4 | 11 | 23 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 4.14 |
| RP | Santana, J.Santana, Julio >> | 32 | 2005 | R | 57 | 30 | 0 | 2 | 1 | 3.18 | .292 | 1.21 | 6.6 | 4.2 | 9.8 | 34.0 | 25 | 12 | 12 | 3 | 16 | 37 | 0 | 0 | 1 | 0 | 0 | 1 | 3 | 3.47 |
| SP | Cabrera, D.Cabrera, Daniel >> | 24 | 2005 | R | 44 | 8 | 0 | 1 | 1 | 5.19 | .366 | 1.73 | 11.3 | 5.6 | 6.8 | 8.2 | 10 | 5 | 5 | 1 | 5 | 6 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 5.00 |
| CL | Rivera, M.Rivera, Mariano † >> | 36 | 2005 | R | 99 | 46 | 0 | 3 | 7 | 3.55 | .276 | 1.11 | 7.7 | 2.3 | 9.0 | 50.2 | 43 | 20 | 20 | 6 | 13 | 50 | 0 | 23 | 1 | 0 | 0 | 2 | 0 | 3.46 |