| SP | Pettitte, A.Pettitte, Andy >> | 33 | 2005 | L | 93 | 22 | 22 | 7 | 11 | 5.02 | .332 | 1.46 | 10.2 | 3.0 | 6.6 | 122.0 | 138 | 72 | 68 | 18 | 40 | 90 | 0 | 0 | 0 | 0 | 9 | 4 | 1 | 4.52 |
| SP | Perez, O.Perez, Odalis >> | 28 | 2005 | L | 52 | 21 | 21 | 3 | 9 | 5.25 | .345 | 1.57 | 10.4 | 3.7 | 5.1 | 106.1 | 123 | 62 | 62 | 20 | 44 | 60 | 0 | 0 | 0 | 0 | 5 | 1 | 4 | 5.59 |
| SP | Cabrera, D.Cabrera, Daniel # >> | 24 | 2005 | R | 44 | 21 | 21 | 11 | 5 | 4.40 | .315 | 1.35 | 8.5 | 3.7 | 8.5 | 118.2 | 112 | 58 | 58 | 12 | 48 | 111 | 0 | 0 | 0 | 0 | 10 | 4 | 6 | 3.76 |
| SP | Marquis, J.Marquis, Jason >> | 27 | 2005 | R | 38 | 21 | 21 | 6 | 10 | 5.17 | .338 | 1.50 | 10.4 | 3.1 | 5.3 | 118.1 | 137 | 72 | 68 | 12 | 40 | 69 | 1 | 0 | 0 | 0 | 13 | 4 | 4 | 4.27 |
| SP | Bedard, E.Bedard, Erik >> | 26 | 2005 | L | 33 | 20 | 20 | 6 | 9 | 5.54 | .343 | 1.55 | 10.0 | 4.1 | 6.9 | 100.2 | 111 | 62 | 62 | 16 | 45 | 77 | 0 | 0 | 0 | 0 | 3 | 2 | 0 | 4.95 |
| RP | Fultz, A.Fultz, Aaron † >> | 32 | 2005 | L | 93 | 54 | 0 | 6 | 3 | 3.25 | .275 | 1.12 | 6.5 | 3.6 | 6.6 | 91.1 | 66 | 34 | 33 | 8 | 36 | 67 | 0 | 2 | 2 | 0 | 0 | 2 | 0 | 3.92 |
| RP | Rincon, J.Rincon, Juan >> | 26 | 2005 | R | 67 | 53 | 0 | 1 | 1 | 4.67 | .331 | 1.47 | 8.9 | 4.4 | 8.4 | 71.1 | 70 | 41 | 37 | 6 | 35 | 66 | 0 | 4 | 1 | 0 | 0 | 1 | 6 | 3.76 |
| RP | Qualls, C.Qualls, Chad >> | 27 | 2005 | R | 45 | 59 | 0 | 3 | 2 | 5.27 | .356 | 1.66 | 11.3 | 3.8 | 6.5 | 71.2 | 89 | 43 | 42 | 7 | 30 | 51 | 0 | 5 | 0 | 0 | 0 | 0 | 1 | 4.11 |
| RP | Majewski, G.Majewski, Gary >> | 25 | 2005 | R | 23 | 38 | 0 | 2 | 1 | 3.11 | .353 | 1.58 | 9.2 | 5.1 | 6.8 | 46.1 | 47 | 16 | 16 | 2 | 26 | 35 | 0 | 5 | 1 | 0 | 0 | 3 | 0 | 3.93 |
| SP | Redman, M.Redman, Mark >> | 31 | 2005 | L | 20 | 24 | 0 | 0 | 2 | 7.61 | .379 | 1.80 | 12.3 | 4.3 | 6.0 | 36.2 | 49 | 31 | 31 | 6 | 17 | 24 | 0 | 2 | 2 | 0 | 0 | 1 | 1 | 5.33 |