| SP | Pettitte, A.Pettitte, Andy † >> | 33 | 2005 | L | 93 | 24 | 24 | 13 | 3 | 2.31 | .263 | 1.04 | 6.9 | 2.4 | 7.3 | 156.0 | 120 | 45 | 40 | 9 | 42 | 127 | 0 | 0 | 0 | 0 | 15 | 5 | 2 | 3.03 |
| SP | Lieber, J.Lieber, Jon # >> | 35 | 2005 | R | 64 | 23 | 23 | 4 | 13 | 5.61 | .315 | 1.35 | 10.0 | 2.2 | 6.7 | 128.1 | 142 | 81 | 80 | 21 | 31 | 95 | 1 | 0 | 0 | 0 | 10 | 4 | 1 | 4.47 |
| SP | Loaiza, E.Loaiza, Esteban # >> | 34 | 2005 | R | 46 | 23 | 23 | 10 | 9 | 4.48 | .308 | 1.30 | 9.5 | 2.3 | 6.9 | 144.2 | 152 | 76 | 72 | 22 | 36 | 110 | 0 | 0 | 0 | 0 | 13 | 5 | 5 | 4.31 |
| SP | Clement, M.Clement, Matt >> | 31 | 2005 | R | 42 | 22 | 22 | 6 | 11 | 6.46 | .357 | 1.60 | 10.7 | 3.8 | 6.7 | 101.2 | 120 | 74 | 73 | 22 | 43 | 75 | 0 | 0 | 0 | 0 | 1 | 6 | 5 | 5.80 |
| RP | Seanez, R.Seanez, Rudy >> | 37 | 2005 | R | 73 | 58 | 0 | 1 | 1 | 3.80 | .322 | 1.41 | 9.7 | 3.0 | 9.3 | 64.0 | 69 | 30 | 27 | 10 | 21 | 66 | 0 | 5 | 2 | 0 | 0 | 1 | 5 | 4.00 |
| RP | Flores, R.Flores, Randy >> | 30 | 2005 | L | 53 | 55 | 0 | 6 | 2 | 3.96 | .306 | 1.28 | 8.6 | 2.9 | 8.5 | 75.0 | 72 | 37 | 33 | 8 | 24 | 71 | 0 | 7 | 3 | 0 | 0 | 3 | 4 | 3.57 |
| RP | Hasegawa, S.Hasegawa, Shigetoshi >> | 37 | 2005 | R | 38 | 51 | 0 | 4 | 4 | 4.21 | .338 | 1.48 | 10.9 | 2.5 | 5.2 | 62.0 | 75 | 35 | 29 | 4 | 17 | 36 | 0 | 5 | 1 | 0 | 0 | 3 | 0 | 3.65 |
| RP | Reitsma, C.Reitsma, Chris >> | 28 | 2005 | R | 27 | 31 | 0 | 1 | 2 | 2.57 | .284 | 1.14 | 7.5 | 2.8 | 5.8 | 42.0 | 35 | 12 | 12 | 2 | 13 | 27 | 0 | 2 | 2 | 0 | 0 | 2 | 2 | 3.40 |
| SP | Towers, J.Towers, Josh >> | 28 | 2005 | R | 26 | 1 | 0 | 0 | 0 | 0.00 | .400 | 2.00 | 18.0 | 0.0 | 0.0 | 1.0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.00 |