| SP | Harden, R.Harden, Rich >> | 24 | 2005 | R | 96 | 12 | 12 | 7 | 2 | 3.59 | .279 | 1.08 | 6.9 | 2.9 | 8.1 | 77.2 | 59 | 31 | 31 | 6 | 25 | 69 | 0 | 0 | 0 | 0 | 7 | 6 | 2 | 3.43 |
| SP | Buehrle, M.Buehrle, Mark # >> | 26 | 2005 | L | 68 | 11 | 11 | 4 | 2 | 4.82 | .321 | 1.35 | 10.2 | 2.1 | 5.7 | 74.2 | 84 | 41 | 40 | 13 | 17 | 47 | 1 | 0 | 0 | 0 | 4 | 5 | 5 | 4.91 |
| RP | Farnsworth, K.Farnsworth, Kyle >> | 29 | 2005 | R | 95 | 31 | 0 | 1 | 1 | 4.81 | .295 | 1.21 | 7.7 | 3.1 | 8.0 | 43.0 | 37 | 23 | 23 | 6 | 15 | 38 | 0 | 4 | 1 | 0 | 0 | 2 | 1 | 4.23 |
| RP | Betancourt, R.Betancourt, Rafael >> | 30 | 2005 | R | 74 | 26 | 0 | 2 | 3 | 5.00 | .337 | 1.50 | 10.0 | 3.5 | 5.5 | 36.0 | 40 | 22 | 20 | 4 | 14 | 22 | 0 | 4 | 4 | 0 | 0 | 1 | 0 | 4.47 |
| RP | Gonzalez, M.Gonzalez, Mike >> | 27 | 2005 | L | 58 | 24 | 0 | 3 | 0 | 4.70 | .308 | 1.34 | 6.3 | 6.0 | 10.2 | 30.2 | 21 | 16 | 16 | 2 | 20 | 34 | 0 | 5 | 1 | 0 | 0 | 0 | 1 | 3.60 |
| RP | Madson, R.Madson, Ryan >> | 25 | 2005 | R | 43 | 19 | 0 | 1 | 1 | 7.23 | .341 | 1.55 | 10.5 | 4.0 | 12.0 | 18.2 | 21 | 15 | 15 | 8 | 8 | 24 | 0 | 1 | 4 | 0 | 0 | 0 | 0 | 7.44 |
| SP | Kazmir, S.Kazmir, Scott >> | 21 | 2005 | L | 31 | 2 | 0 | 1 | 1 | 3.38 | .200 | 0.75 | 9.0 | 0.0 | 9.0 | 2.2 | 2 | 1 | 1 | 1 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 7.50 |
| SP | Fossum, C.Fossum, Casey >> | 27 | 2005 | L | 18 | 12 | 0 | 2 | 2 | 5.50 | .426 | 2.17 | 15.5 | 4.0 | 7.0 | 18.0 | 31 | 12 | 11 | 3 | 8 | 14 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 5.11 |