| SP | Halladay, R.Halladay, Roy † >> | 28 | 2005 | R | 95 | 24 | 24 | 12 | 10 | 3.72 | .284 | 1.17 | 8.5 | 2.1 | 6.1 | 188.2 | 177 | 83 | 78 | 11 | 44 | 128 | 8 | 0 | 0 | 1 | 13 | 3 | 2 | 3.15 |
| SP | Weaver, J.Weaver, Jeff >> | 29 | 2005 | R | 79 | 23 | 23 | 5 | 10 | 4.91 | .320 | 1.37 | 10.0 | 2.3 | 5.4 | 141.0 | 157 | 79 | 77 | 18 | 36 | 84 | 0 | 0 | 0 | 0 | 12 | 6 | 4 | 4.36 |
| SP | Buehrle, M.Buehrle, Mark >> | 26 | 2005 | L | 68 | 23 | 23 | 12 | 9 | 4.34 | .337 | 1.50 | 10.5 | 3.1 | 6.1 | 159.2 | 185 | 78 | 77 | 13 | 54 | 108 | 3 | 0 | 0 | 0 | 14 | 4 | 5 | 3.80 |
| SP | Benson, K.Benson, Kris >> | 31 | 2005 | R | 53 | 22 | 22 | 4 | 11 | 5.52 | .359 | 1.67 | 11.8 | 3.2 | 5.5 | 132.0 | 173 | 89 | 81 | 14 | 47 | 81 | 0 | 0 | 0 | 0 | 7 | 2 | 3 | 4.27 |
| SP | Arroyo, B.Arroyo, Bronson >> | 28 | 2005 | R | 37 | 22 | 22 | 5 | 10 | 4.36 | .335 | 1.45 | 10.4 | 2.7 | 5.9 | 119.2 | 138 | 63 | 58 | 14 | 36 | 78 | 0 | 0 | 0 | 0 | 8 | 7 | 4 | 4.30 |
| RP | Politte, C.Politte, Cliff # >> | 31 | 2005 | R | 96 | 57 | 0 | 5 | 5 | 4.15 | .305 | 1.32 | 8.5 | 3.5 | 5.7 | 86.2 | 81 | 42 | 40 | 13 | 33 | 54 | 0 | 6 | 5 | 0 | 0 | 0 | 1 | 4.86 |
| RP | Benoit, J.Benoit, Joaquin >> | 28 | 2005 | R | 61 | 39 | 0 | 5 | 5 | 4.29 | .297 | 1.24 | 7.1 | 4.0 | 8.4 | 63.0 | 50 | 31 | 30 | 6 | 28 | 59 | 0 | 6 | 3 | 0 | 0 | 2 | 2 | 3.79 |
| RP | Donnelly, B.Donnelly, Brendan >> | 34 | 2005 | R | 46 | 18 | 0 | 0 | 0 | 2.95 | .257 | 1.04 | 5.5 | 4.0 | 6.0 | 18.1 | 11 | 6 | 6 | 0 | 8 | 12 | 0 | 3 | 0 | 0 | 0 | 0 | 1 | 3.00 |
| RP | Carrara, G.Carrara, Giovanni >> | 37 | 2005 | R | 36 | 18 | 0 | 0 | 0 | 2.49 | .293 | 1.20 | 7.7 | 3.4 | 4.7 | 21.2 | 18 | 6 | 6 | 2 | 8 | 11 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 4.48 |
| SP | Elarton, S.Elarton, Scott >> | 29 | 2005 | R | 36 | 1 | 1 | 0 | 1 | 8.31 | .500 | 3.00 | 24.8 | 4.5 | 9.0 | 4.1 | 11 | 4 | 4 | 2 | 2 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 9.00 |
| SP | Mulder, M.Mulder, Mark >> | 28 | 2005 | L | 24 | 2 | 0 | 0 | 0 | 2.08 | .409 | 2.08 | 9.0 | 11.3 | 6.8 | 4.1 | 4 | 1 | 1 | 0 | 5 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 5.25 |