| SP | Peavy, J.Peavy, Jake † # >> | 24 | 2005 | R | 97 | 22 | 22 | 13 | 5 | 3.17 | .271 | 1.10 | 8.0 | 2.0 | 8.5 | 150.1 | 133 | 54 | 53 | 12 | 33 | 142 | 1 | 0 | 0 | 0 | 15 | 2 | 2 | 2.85 |
| SP | Blanton, J.Blanton, Joe >> | 25 | 2005 | R | 74 | 21 | 21 | 8 | 8 | 5.24 | .354 | 1.61 | 10.7 | 3.8 | 6.1 | 122.0 | 145 | 77 | 71 | 12 | 51 | 83 | 0 | 0 | 0 | 0 | 9 | 5 | 2 | 4.30 |
| SP | Contreras, J.Contreras, Jose >> | 34 | 2005 | R | 77 | 21 | 21 | 7 | 9 | 5.52 | .338 | 1.51 | 8.9 | 4.8 | 6.0 | 120.2 | 118 | 81 | 74 | 15 | 64 | 80 | 0 | 0 | 0 | 0 | 7 | 3 | 6 | 4.97 |
| SP | Millwood, K.Millwood, Kevin # >> | 31 | 2005 | R | 73 | 21 | 21 | 6 | 9 | 5.31 | .332 | 1.47 | 10.3 | 3.0 | 6.2 | 137.1 | 157 | 89 | 81 | 16 | 45 | 94 | 1 | 0 | 0 | 0 | 8 | 3 | 2 | 4.20 |
| SP | Wakefield, T.Wakefield, Tim >> | 39 | 2005 | R | 69 | 20 | 20 | 7 | 9 | 4.73 | .321 | 1.39 | 10.0 | 2.5 | 6.8 | 131.1 | 146 | 72 | 69 | 20 | 37 | 99 | 2 | 0 | 0 | 0 | 11 | 3 | 0 | 4.39 |
| RP | Turnbow, D.Turnbow, Derrick >> | 27 | 2005 | R | 82 | 37 | 0 | 0 | 1 | 5.45 | .351 | 1.57 | 8.5 | 5.8 | 6.8 | 36.1 | 34 | 23 | 22 | 6 | 23 | 27 | 0 | 4 | 1 | 0 | 0 | 2 | 5 | 5.75 |
| RP | Isringhausen, J.Isringhausen, Jason >> | 33 | 2005 | R | 72 | 26 | 0 | 0 | 2 | 3.90 | .320 | 1.41 | 9.7 | 3.3 | 7.3 | 27.2 | 29 | 14 | 12 | 4 | 10 | 22 | 0 | 0 | 1 | 0 | 0 | 0 | 3 | 4.41 |
| RP | Calero, K.Calero, Kiko >> | 30 | 2005 | R | 68 | 18 | 0 | 1 | 2 | 4.86 | .296 | 1.20 | 9.0 | 2.3 | 7.3 | 16.2 | 16 | 9 | 9 | 1 | 4 | 13 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 3.13 |
| RP | Hammond, C.Hammond, Chris >> | 39 | 2005 | L | 60 | 19 | 0 | 0 | 1 | 4.64 | .390 | 1.92 | 12.4 | 5.1 | 9.9 | 21.1 | 29 | 11 | 11 | 7 | 12 | 23 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 6.86 |
| CL | Shields, S.Shields, Scot >> | 30 | 2005 | R | 78 | 37 | 0 | 2 | 3 | 3.19 | .313 | 1.31 | 8.3 | 3.8 | 7.3 | 36.2 | 33 | 13 | 13 | 0 | 15 | 29 | 0 | 6 | 3 | 0 | 0 | 2 | 6 | 2.81 |
| SU | Wagner, B.Wagner, Billy >> | 34 | 2005 | L | 100 | 39 | 0 | 0 | 6 | 4.27 | .291 | 1.19 | 7.8 | 2.9 | 9.8 | 46.1 | 40 | 22 | 22 | 2 | 15 | 50 | 0 | 19 | 2 | 0 | 0 | 2 | 1 | 2.50 |
| SP | Sabathia, C.Sabathia, CC >> | 25 | 2005 | L | 66 | 7 | 0 | 1 | 0 | 6.00 | .331 | 1.37 | 9.7 | 2.7 | 7.3 | 27.0 | 29 | 20 | 18 | 6 | 8 | 22 | 0 | 0 | 0 | 0 | 0 | 3 | 2 | 5.48 |