| SP | Johnson, R.Johnson, Randy $$ >> | 42 | 2005 | L | 90 | 22 | 22 | 8 | 10 | 4.22 | .320 | 1.37 | 9.0 | 3.4 | 7.4 | 138.2 | 138 | 66 | 65 | 17 | 52 | 114 | 2 | 0 | 0 | 1 | 13 | 6 | 1 | 4.21 |
| SP | Prior, M.Prior, Mark # >> | 25 | 2005 | R | 85 | 21 | 21 | 9 | 8 | 3.87 | .277 | 1.10 | 7.9 | 2.1 | 9.3 | 135.0 | 118 | 60 | 58 | 16 | 31 | 139 | 4 | 0 | 0 | 1 | 12 | 6 | 2 | 3.30 |
| SP | Oswalt, R.Oswalt, Roy # >> | 28 | 2005 | R | 71 | 19 | 19 | 5 | 7 | 5.79 | .350 | 1.55 | 11.0 | 3.0 | 5.4 | 101.0 | 123 | 67 | 65 | 18 | 34 | 61 | 0 | 0 | 0 | 0 | 6 | 6 | 3 | 5.30 |
| SP | Vazquez, J.Vazquez, Javier >> | 29 | 2005 | R | 61 | 22 | 21 | 8 | 11 | 5.36 | .337 | 1.51 | 11.6 | 2.1 | 6.1 | 127.2 | 163 | 78 | 76 | 11 | 30 | 86 | 0 | 0 | 0 | 0 | 10 | 2 | 4 | 3.53 |
| CL | Farnsworth, K.Farnsworth, Kyle >> | 29 | 2005 | R | 95 | 37 | 0 | 1 | 2 | 3.03 | .326 | 1.45 | 8.1 | 5.2 | 9.9 | 38.2 | 34 | 14 | 13 | 6 | 22 | 42 | 0 | 25 | 3 | 0 | 0 | 0 | 2 | 4.58 |
| RP | Duchscherer, J.Duchscherer, Justin $ >> | 28 | 2005 | R | 89 | 55 | 0 | 5 | 1 | 2.14 | .280 | 1.17 | 8.1 | 2.4 | 8.7 | 59.0 | 53 | 15 | 14 | 5 | 16 | 57 | 0 | 0 | 2 | 0 | 0 | 0 | 1 | 2.98 |
| RP | Flores, R.Flores, Randy >> | 30 | 2005 | L | 53 | 51 | 0 | 2 | 0 | 3.73 | .343 | 1.47 | 9.3 | 4.1 | 8.7 | 31.1 | 32 | 13 | 13 | 4 | 14 | 30 | 0 | 0 | 1 | 0 | 0 | 3 | 0 | 4.39 |
| RP | Rodriguez, F.Rodriguez, Francisco >> | 23 | 2005 | R | 79 | 25 | 0 | 1 | 0 | 3.46 | .271 | 1.08 | 5.5 | 4.2 | 8.3 | 26.0 | 16 | 10 | 10 | 4 | 12 | 24 | 0 | 0 | 0 | 0 | 0 | 1 | 3 | 4.65 |
| SP | Harang, A.Harang, Aaron >> | 27 | 2005 | R | 51 | 17 | 1 | 0 | 1 | 5.57 | .366 | 1.73 | 10.6 | 5.0 | 7.3 | 63.0 | 74 | 41 | 39 | 9 | 35 | 51 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 4.90 |