| SP | Santana, J.Santana, Johan >> | 26 | 2005 | L | 99 | 11 | 11 | 7 | 4 | 2.27 | .229 | 0.88 | 6.4 | 1.6 | 9.5 | 87.1 | 62 | 23 | 22 | 13 | 15 | 92 | 6 | 0 | 0 | 1 | 9 | 1 | 0 | 3.38 |
| SP | Weaver, J.Weaver, Jeff >> | 29 | 2005 | R | 79 | 11 | 11 | 3 | 4 | 5.86 | .371 | 1.65 | 11.2 | 3.7 | 6.2 | 58.1 | 72 | 40 | 38 | 9 | 24 | 40 | 0 | 0 | 0 | 0 | 3 | 7 | 1 | 5.24 |
| SP | Smoltz, J.Smoltz, John # >> | 38 | 2005 | R | 84 | 11 | 11 | 2 | 4 | 5.16 | .296 | 1.25 | 9.1 | 2.1 | 7.2 | 61.0 | 62 | 38 | 35 | 10 | 14 | 49 | 0 | 0 | 0 | 0 | 4 | 1 | 1 | 4.26 |
| CL | Nathan, J.Nathan, Joe $$ >> | 31 | 2005 | R | 97 | 19 | 0 | 2 | 2 | 2.84 | .278 | 1.11 | 6.2 | 3.8 | 9.0 | 19.0 | 13 | 6 | 6 | 1 | 8 | 19 | 0 | 13 | 2 | 0 | 0 | 1 | 0 | 3.11 |
| RP | Valverde, J.Valverde, Jose >> | 26 | 2005 | R | 84 | 37 | 0 | 0 | 0 | 4.38 | .357 | 1.66 | 11.3 | 4.1 | 10.5 | 24.2 | 30 | 12 | 12 | 2 | 11 | 28 | 0 | 0 | 1 | 0 | 0 | 0 | 2 | 3.13 |
| RP | Seanez, R.Seanez, Rudy >> | 37 | 2005 | R | 73 | 18 | 0 | 1 | 1 | 6.32 | .329 | 1.47 | 9.0 | 4.8 | 9.6 | 15.2 | 15 | 11 | 11 | 3 | 8 | 16 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 5.07 |
| RP | Guardado, E.Guardado, Eddie >> | 35 | 2005 | L | 51 | 36 | 0 | 2 | 1 | 3.38 | .301 | 1.29 | 8.6 | 3.0 | 6.4 | 24.0 | 23 | 11 | 9 | 5 | 8 | 17 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 5.29 |
| RP | Sisco, A.Sisco, Andrew >> | 22 | 2005 | L | 26 | 35 | 0 | 0 | 0 | 4.19 | .348 | 1.55 | 6.6 | 7.6 | 9.0 | 19.1 | 14 | 9 | 9 | 4 | 16 | 19 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 6.42 |
| SP | Lackey, J.Lackey, John >> | 27 | 2005 | R | 50 | 17 | 0 | 2 | 2 | 5.08 | .342 | 1.49 | 9.8 | 3.7 | 6.1 | 44.1 | 48 | 27 | 25 | 4 | 18 | 30 | 0 | 0 | 0 | 0 | 0 | 3 | 2 | 4.25 |