| SP | Martinez, P.Martinez, Pedro >> | 34 | 2005 | R | 100 | 22 | 22 | 6 | 14 | 4.26 | .332 | 1.46 | 9.8 | 3.3 | 7.2 | 148.0 | 161 | 87 | 70 | 16 | 55 | 118 | 2 | 0 | 0 | 1 | 12 | 5 | 0 | 4.03 |
| SP | Colon, B.Colon, Bartolo # >> | 32 | 2005 | R | 80 | 21 | 21 | 5 | 10 | 4.86 | .334 | 1.45 | 11.2 | 1.9 | 6.0 | 127.2 | 158 | 80 | 69 | 12 | 27 | 84 | 0 | 0 | 0 | 0 | 11 | 7 | 4 | 3.71 |
| SP | Loaiza, E.Loaiza, Esteban >> | 34 | 2005 | R | 46 | 20 | 20 | 9 | 6 | 6.33 | .344 | 1.52 | 10.4 | 3.4 | 6.8 | 112.1 | 129 | 85 | 79 | 19 | 42 | 84 | 0 | 0 | 0 | 0 | 6 | 6 | 4 | 4.99 |
| CL | Seanez, R.Seanez, Rudy † >> | 37 | 2005 | R | 73 | 42 | 0 | 6 | 3 | 2.06 | .268 | 1.01 | 6.7 | 2.5 | 8.4 | 43.2 | 32 | 10 | 10 | 4 | 12 | 40 | 0 | 25 | 2 | 0 | 0 | 4 | 5 | 3.47 |
| SU | Linebrink, S.Linebrink, Scott >> | 29 | 2005 | R | 85 | 53 | 0 | 2 | 1 | 3.25 | .320 | 1.39 | 9.2 | 3.4 | 7.2 | 55.1 | 56 | 27 | 20 | 5 | 21 | 44 | 0 | 0 | 2 | 0 | 0 | 1 | 1 | 3.78 |
| RP | Street, H.Street, Huston >> | 22 | 2005 | R | 91 | 49 | 0 | 6 | 1 | 3.23 | .289 | 1.19 | 7.2 | 3.6 | 6.5 | 55.2 | 44 | 20 | 20 | 7 | 22 | 40 | 0 | 3 | 2 | 0 | 0 | 2 | 0 | 4.51 |
| RP | Gonzalez, M.Gonzalez, Mike >> | 27 | 2005 | L | 58 | 41 | 0 | 2 | 0 | 2.02 | .291 | 1.21 | 6.4 | 4.6 | 10.3 | 35.2 | 25 | 10 | 8 | 0 | 18 | 40 | 0 | 2 | 2 | 0 | 0 | 1 | 0 | 2.34 |
| RP | Cordero, C.Cordero, Chad >> | 23 | 2005 | R | 88 | 39 | 0 | 2 | 2 | 3.40 | .270 | 1.06 | 6.9 | 2.8 | 7.8 | 39.2 | 30 | 15 | 15 | 6 | 12 | 34 | 0 | 0 | 1 | 0 | 0 | 2 | 0 | 4.33 |
| RP | Hoffman, T.Hoffman, Trevor >> | 38 | 2005 | R | 65 | 31 | 0 | 2 | 1 | 4.54 | .318 | 1.34 | 8.2 | 4.1 | 8.5 | 33.2 | 30 | 17 | 17 | 7 | 15 | 31 | 0 | 0 | 0 | 0 | 0 | 2 | 1 | 5.42 |
| RP | Fuentes, B.Fuentes, Brian >> | 30 | 2005 | L | 63 | 51 | 0 | 4 | 0 | 3.86 | .326 | 1.38 | 7.7 | 4.7 | 10.5 | 42.0 | 36 | 19 | 18 | 4 | 22 | 49 | 0 | 1 | 1 | 0 | 0 | 3 | 2 | 3.69 |
| RP | Dempster, R.Dempster, Ryan >> | 28 | 2005 | R | 28 | 8 | 0 | 0 | 0 | 6.35 | .433 | 2.29 | 18.0 | 5.4 | 5.4 | 5.2 | 10 | 6 | 4 | 0 | 3 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 3.60 |