| SP | Clemens, R.Clemens, Roger $ >> | 43 | 2005 | R | 98 | 24 | 24 | 9 | 9 | 3.77 | .292 | 1.20 | 8.1 | 2.7 | 7.4 | 162.1 | 146 | 70 | 68 | 17 | 48 | 134 | 4 | 0 | 0 | 1 | 16 | 7 | 2 | 3.73 |
| SP | Blanton, J.Blanton, Joe # >> | 25 | 2005 | R | 74 | 23 | 23 | 8 | 8 | 4.70 | .339 | 1.45 | 9.1 | 3.9 | 5.9 | 138.0 | 140 | 76 | 72 | 12 | 60 | 90 | 1 | 0 | 0 | 0 | 9 | 12 | 4 | 4.39 |
| SP | Millwood, K.Millwood, Kevin >> | 31 | 2005 | R | 73 | 23 | 23 | 9 | 6 | 5.03 | .342 | 1.54 | 10.0 | 3.9 | 7.0 | 136.0 | 151 | 83 | 76 | 20 | 59 | 106 | 0 | 0 | 0 | 0 | 10 | 2 | 4 | 4.70 |
| CL | Street, H.Street, Huston >> | 22 | 2005 | R | 91 | 46 | 0 | 1 | 2 | 3.80 | .301 | 1.27 | 8.6 | 3.0 | 6.9 | 42.2 | 40 | 21 | 18 | 5 | 14 | 32 | 0 | 16 | 3 | 0 | 0 | 1 | 1 | 4.10 |
| SU | Rodriguez, F.Rodriguez, Francisco >> | 23 | 2005 | R | 79 | 45 | 0 | 1 | 1 | 3.35 | .297 | 1.25 | 6.2 | 5.2 | 10.6 | 45.2 | 31 | 17 | 17 | 6 | 26 | 53 | 0 | 1 | 2 | 0 | 0 | 1 | 2 | 4.18 |
| RP | Linebrink, S.Linebrink, Scott >> | 29 | 2005 | R | 85 | 39 | 0 | 3 | 0 | 3.10 | .315 | 1.35 | 9.2 | 3.2 | 7.2 | 40.2 | 41 | 14 | 14 | 5 | 14 | 32 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 4.15 |
| RP | Isringhausen, J.Isringhausen, Jason >> | 33 | 2005 | R | 72 | 45 | 0 | 2 | 3 | 4.00 | .322 | 1.42 | 7.2 | 5.6 | 5.6 | 45.0 | 36 | 20 | 20 | 8 | 28 | 28 | 0 | 10 | 4 | 0 | 0 | 0 | 0 | 5.93 |
| RP | Gonzalez, M.Gonzalez, Mike >> | 27 | 2005 | L | 58 | 60 | 0 | 3 | 2 | 4.96 | .335 | 1.51 | 8.7 | 5.0 | 8.9 | 61.2 | 59 | 35 | 34 | 4 | 34 | 60 | 0 | 1 | 1 | 0 | 0 | 0 | 4 | 3.56 |
| RP | Fuentes, B.Fuentes, Brian >> | 30 | 2005 | L | 63 | 49 | 0 | 2 | 1 | 6.61 | .361 | 1.63 | 11.3 | 3.5 | 9.0 | 31.1 | 39 | 24 | 23 | 6 | 12 | 31 | 0 | 0 | 1 | 0 | 0 | 2 | 2 | 4.87 |