| SP | Santana, J.Santana, Johan # $ >> | 33 | 2004 | L | 99 | 18 | 18 | 11 | 4 | 2.83 | .234 | 0.91 | 6.5 | 1.7 | 8.3 | 136.2 | 98 | 43 | 43 | 19 | 26 | 126 | 4 | 0 | 0 | 0 | 14 | 1 | 3 | 3.56 |
| SP | Jackson, E.Jackson, Edwin $$ >> | 29 | 2003 | R | 96 | 17 | 17 | 8 | 8 | 4.15 | .306 | 1.26 | 8.0 | 3.3 | 6.7 | 119.1 | 106 | 55 | 55 | 18 | 44 | 88 | 3 | 0 | 0 | 0 | 9 | 8 | 6 | 4.80 |
| SP | James, C.James, Chuck $ >> | 31 | 2006 | L | 89 | 17 | 17 | 6 | 7 | 5.29 | .310 | 1.31 | 8.5 | 3.3 | 7.2 | 98.2 | 93 | 60 | 58 | 24 | 36 | 78 | 0 | 0 | 0 | 0 | 7 | 4 | 1 | 5.82 |
| SP | Webb, B.Webb, Brandon # $ >> | 33 | 2003 | R | 79 | 16 | 16 | 3 | 10 | 6.60 | .356 | 1.64 | 10.6 | 4.3 | 7.5 | 92.2 | 108 | 75 | 68 | 20 | 44 | 77 | 1 | 0 | 0 | 0 | 3 | 2 | 3 | 5.65 |
| SP | Patino, L.Patino, Luis $ >> | 36 | 2021 | R | 70 | 12 | 12 | 0 | 7 | 6.14 | .323 | 1.40 | 11.5 | 1.2 | 7.4 | 58.2 | 74 | 41 | 40 | 13 | 8 | 48 | 0 | 0 | 0 | 0 | 3 | 2 | 3 | 4.78 |
| CL | Valverde, J.Valverde, Jose $$ >> | 33 | 2003 | R | 100 | 31 | 0 | 3 | 2 | 1.19 | .254 | 1.02 | 5.1 | 4.2 | 12.0 | 30.1 | 17 | 4 | 4 | 2 | 14 | 40 | 0 | 25 | 1 | 0 | 0 | 0 | 0 | 2.60 |
| RP | Papelbon, J.Papelbon, Jonathan $$ >> | 32 | 2006 | R | 88 | 44 | 0 | 2 | 0 | 3.64 | .281 | 1.15 | 8.4 | 1.9 | 8.4 | 47.0 | 44 | 20 | 19 | 9 | 10 | 44 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 4.32 |
| RP | Sanchez, E.Sanchez, Eduardo $$ >> | 23 | 2011 | R | 85 | 31 | 0 | 1 | 2 | 2.61 | .244 | 0.94 | 5.3 | 3.3 | 8.8 | 41.1 | 24 | 14 | 12 | 5 | 15 | 40 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 3.80 |
| RP | Bentz, C.Bentz, Chad $ >> | 32 | 2004 | L | 74 | 41 | 0 | 0 | 1 | 4.65 | .316 | 1.39 | 6.7 | 5.8 | 5.5 | 31.0 | 23 | 17 | 16 | 5 | 20 | 19 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5.81 |
| RP | Brazoban, Y.Brazoban, Yhency $ >> | 32 | 2004 | R | 73 | 21 | 0 | 3 | 0 | 3.92 | .279 | 1.06 | 6.3 | 3.6 | 8.6 | 20.2 | 14 | 9 | 9 | 2 | 8 | 19 | 0 | 1 | 0 | 0 | 0 | 2 | 1 | 3.90 |
| RP | Aceves, A.Aceves, Alfredo >> | 30 | 2009 | R | 55 | 16 | 0 | 1 | 1 | 3.32 | .278 | 1.02 | 7.7 | 1.7 | 5.6 | 21.2 | 18 | 8 | 8 | 2 | 4 | 13 | 0 | 1 | 0 | 0 | 0 | 3 | 0 | 4.00 |