| SP | Billingsley, C.Billingsley, Chad $$ >> | 28 | 2006 | R | 96 | 17 | 17 | 9 | 6 | 3.96 | .223 | 0.84 | 6.0 | 1.5 | 5.2 | 111.1 | 74 | 51 | 49 | 16 | 19 | 64 | 7 | 0 | 0 | 2 | 8 | 3 | 1 | 4.32 |
| SP | Buehrle, M.Buehrle, Mark # $$ >> | 33 | 2001 | L | 85 | 17 | 17 | 8 | 7 | 2.67 | .250 | 0.97 | 7.5 | 1.3 | 4.6 | 128.0 | 106 | 41 | 38 | 12 | 18 | 65 | 11 | 0 | 0 | 2 | 12 | 4 | 0 | 3.72 |
| SP | Floyd, G.Floyd, Gavin $$ >> | 29 | 2004 | R | 89 | 17 | 17 | 7 | 7 | 4.70 | .316 | 1.36 | 9.6 | 2.7 | 5.9 | 99.2 | 106 | 55 | 52 | 13 | 30 | 65 | 3 | 0 | 0 | 1 | 7 | 2 | 3 | 4.36 |
| SP | Latos, M.Latos, Mat $$ >> | 24 | 2010 | R | 83 | 14 | 14 | 6 | 4 | 3.78 | .269 | 1.08 | 6.9 | 2.9 | 8.9 | 78.2 | 60 | 39 | 33 | 13 | 25 | 77 | 2 | 0 | 0 | 1 | 7 | 2 | 1 | 4.23 |
| CL | Marmol, C.Marmol, Carlos $$ >> | 30 | 2007 | R | 91 | 33 | 0 | 3 | 2 | 2.31 | .262 | 1.01 | 6.1 | 3.1 | 8.8 | 50.2 | 34 | 14 | 13 | 3 | 17 | 49 | 0 | 5 | 0 | 0 | 0 | 3 | 7 | 3.02 |
| RP | Nunez, L.Nunez, Leo $$ >> | 29 | 2008 | R | 66 | 33 | 0 | 2 | 2 | 3.47 | .267 | 1.09 | 8.0 | 2.0 | 6.7 | 46.2 | 41 | 18 | 18 | 5 | 10 | 34 | 0 | 3 | 0 | 0 | 0 | 0 | 4 | 3.59 |
| RP | Ledezma, W.Ledezma, Wilfredo $$ >> | 31 | 2003 | L | 63 | 33 | 0 | 1 | 0 | 3.86 | .285 | 1.15 | 8.6 | 1.8 | 6.3 | 44.1 | 42 | 19 | 19 | 10 | 9 | 31 | 0 | 1 | 0 | 0 | 0 | 2 | 1 | 5.30 |
| RP | Peralta, J.Peralta, Joel >> | 36 | 2010 | R | 57 | 21 | 0 | 0 | 0 | 2.66 | .237 | 0.93 | 6.3 | 2.3 | 7.4 | 23.2 | 16 | 7 | 7 | 3 | 6 | 19 | 0 | 1 | 2 | 0 | 0 | 0 | 0 | 3.83 |
| RP | Gonzalez, M.Gonzalez, Mike >> | 34 | 2004 | L | 49 | 14 | 0 | 0 | 1 | 3.86 | .258 | 1.04 | 6.2 | 3.4 | 7.3 | 16.1 | 11 | 7 | 7 | 5 | 6 | 13 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 6.56 |
| RP | Luebke, C.Luebke, Cory $$ >> | 27 | 2011 | L | 59 | 22 | 0 | 3 | 0 | 4.28 | .305 | 1.32 | 8.0 | 4.0 | 9.7 | 27.1 | 24 | 13 | 13 | 5 | 12 | 29 | 0 | 4 | 0 | 0 | 0 | 0 | 1 | 4.59 |