| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 91 | 5 | 5 | 3 | 0 | 4.08 | .279 | 1.13 | 8.0 | 2.3 | 8.2 | 35.1 | 31 | 16 | 16 | 6 | 9 | 32 | 1 | 0 | 0 | 1 | 2 | 1 | 0 | 4.26 |
| SP | Flaherty, J.Flaherty, Jack >> | 23 | 2019 | R | 82 | 5 | 5 | 1 | 1 | 3.31 | .305 | 1.29 | 9.6 | 2.3 | 10.7 | 32.2 | 34 | 12 | 12 | 8 | 8 | 38 | 0 | 0 | 0 | 0 | 4 | 1 | 0 | 4.72 |
| SP | Harvey, M.Harvey, Matt >> | 24 | 2013 | R | 77 | 5 | 5 | 1 | 2 | 7.90 | .388 | 1.87 | 13.7 | 3.3 | 7.7 | 27.1 | 41 | 26 | 24 | 6 | 10 | 23 | 1 | 0 | 0 | 0 | 2 | 1 | 1 | 5.41 |
| SP | Millwood, K.Millwood, Kevin >> | 25 | 1999 | R | 70 | 5 | 5 | 2 | 3 | 6.35 | .366 | 1.69 | 12.5 | 2.9 | 7.7 | 28.1 | 39 | 20 | 20 | 7 | 9 | 24 | 0 | 0 | 0 | 0 | 2 | 1 | 0 | 5.61 |
| RP | Feliz, N.Feliz, Neftali >> | 21 | 2009 | R | 97 | 12 | 0 | 0 | 0 | 5.71 | .288 | 1.10 | 5.3 | 4.8 | 9.5 | 17.1 | 10 | 11 | 11 | 3 | 9 | 18 | 0 | 1 | 1 | 0 | 0 | 2 | 0 | 5.12 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 91 | 11 | 0 | 0 | 0 | 1.17 | .179 | 0.65 | 3.6 | 2.4 | 8.4 | 15.1 | 6 | 2 | 2 | 0 | 4 | 14 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 1.93 |
| RP | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 82 | 9 | 0 | 1 | 0 | 2.19 | .260 | 0.97 | 6.0 | 3.0 | 11.3 | 12.1 | 8 | 3 | 3 | 2 | 4 | 15 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 3.92 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 75 | 8 | 0 | 3 | 1 | 4.66 | .370 | 1.76 | 15.0 | 2.0 | 10.0 | 9.2 | 15 | 5 | 5 | 2 | 2 | 10 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 4.33 |
| RP | Sutter, B.Sutter, Bruce >> | 24 | 1977 | R | 65 | 6 | 0 | 0 | 0 | 5.14 | .400 | 1.71 | 11.6 | 3.9 | 9.0 | 7.0 | 9 | 4 | 4 | 1 | 3 | 7 | 0 | 0 | 1 | 0 | 0 | 2 | 0 | 5.00 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 64 | 6 | 0 | 0 | 1 | 7.04 | .395 | 1.96 | 11.6 | 7.7 | 6.4 | 7.2 | 9 | 6 | 6 | 0 | 6 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.14 |
| SP | Nelson, R.Nelson, Roger >> | 28 | 1972 | R | 88 | 5 | 0 | 1 | 1 | 6.35 | .469 | 2.65 | 23.4 | 3.6 | 10.8 | 5.2 | 13 | 5 | 4 | 0 | 2 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1.80 |