| SP | Greinke, Z.Greinke, Zack $ >> | 32 | 2015 | R | 94 | 31 | 31 | 16 | 7 | 3.79 | .289 | 1.18 | 8.3 | 2.4 | 6.2 | 209.0 | 192 | 104 | 88 | 32 | 55 | 144 | 7 | 0 | 0 | 2 | 19 | 8 | 7 | 4.52 |
| SP | Hernandez, F.Hernandez, Felix >> | 28 | 2014 | R | 87 | 30 | 30 | 7 | 15 | 5.31 | .333 | 1.46 | 9.8 | 3.4 | 7.5 | 166.0 | 181 | 113 | 98 | 25 | 62 | 138 | 2 | 0 | 0 | 0 | 13 | 6 | 6 | 4.52 |
| SP | Flaherty, J.Flaherty, Jack >> | 23 | 2019 | R | 83 | 29 | 29 | 7 | 9 | 3.90 | .329 | 1.43 | 8.9 | 4.0 | 9.1 | 166.0 | 165 | 86 | 72 | 14 | 73 | 167 | 0 | 0 | 0 | 0 | 14 | 6 | 5 | 3.51 |
| SP | Tanana, F.Tanana, Frank >> | 23 | 1976 | L | 73 | 30 | 30 | 11 | 14 | 3.59 | .292 | 1.21 | 7.9 | 3.0 | 7.3 | 215.1 | 189 | 108 | 86 | 18 | 72 | 175 | 11 | 0 | 0 | 2 | 20 | 5 | 6 | 3.53 |
| SP | Saberhagen, B.Saberhagen, Bret >> | 25 | 1989 | R | 64 | 31 | 29 | 7 | 15 | 5.50 | .324 | 1.40 | 9.7 | 2.9 | 7.0 | 173.1 | 187 | 115 | 106 | 24 | 56 | 135 | 3 | 0 | 0 | 0 | 9 | 6 | 5 | 4.32 |
| RP | Kimbrel, C.Kimbrel, Craig † >> | 24 | 2012 | R | 100 | 90 | 0 | 8 | 2 | 2.76 | .271 | 1.10 | 6.6 | 3.3 | 10.8 | 117.1 | 86 | 37 | 36 | 6 | 43 | 140 | 0 | 4 | 4 | 0 | 0 | 2 | 3 | 2.43 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 91 | 83 | 0 | 10 | 6 | 3.74 | .280 | 1.14 | 7.0 | 3.3 | 10.9 | 98.2 | 76 | 45 | 41 | 12 | 36 | 119 | 0 | 3 | 2 | 0 | 0 | 3 | 0 | 3.36 |
| RP | Capps, C.Capps, Carter >> | 24 | 2015 | R | 82 | 71 | 0 | 3 | 3 | 3.92 | .279 | 1.13 | 6.7 | 3.5 | 10.5 | 82.2 | 61 | 37 | 36 | 7 | 32 | 96 | 0 | 7 | 2 | 0 | 0 | 3 | 2 | 3.05 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 74 | 46 | 0 | 1 | 3 | 4.25 | .296 | 1.19 | 8.7 | 2.0 | 10.2 | 53.0 | 51 | 25 | 25 | 8 | 12 | 60 | 0 | 5 | 2 | 0 | 0 | 4 | 0 | 3.60 |