| SP | Verlander, J.Verlander, Justin † >> | 36 | 2019 | R | 99 | 19 | 19 | 12 | 4 | 3.39 | .299 | 1.27 | 8.7 | 2.8 | 8.8 | 130.0 | 125 | 53 | 49 | 15 | 40 | 127 | 1 | 0 | 0 | 1 | 11 | 1 | 1 | 3.49 |
| SP | Tanana, F.Tanana, Frank >> | 23 | 1976 | L | 74 | 18 | 18 | 6 | 8 | 5.89 | .349 | 1.58 | 10.5 | 3.9 | 7.0 | 123.2 | 143 | 87 | 81 | 20 | 53 | 95 | 4 | 0 | 0 | 0 | 4 | 3 | 1 | 4.93 |
| SP | Schilling, C.Schilling, Curt >> | 36 | 2002 | R | 65 | 20 | 18 | 7 | 8 | 4.18 | .304 | 1.29 | 9.5 | 2.1 | 9.5 | 135.2 | 143 | 67 | 63 | 21 | 32 | 142 | 5 | 2 | 0 | 1 | 9 | 3 | 5 | 3.70 |
| RP | Gagne, E.Gagne, Eric † >> | 27 | 2003 | R | 98 | 49 | 0 | 4 | 2 | 2.54 | .276 | 1.11 | 6.2 | 3.9 | 11.0 | 60.1 | 41 | 18 | 17 | 3 | 26 | 73 | 0 | 10 | 2 | 0 | 0 | 2 | 0 | 2.62 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 91 | 33 | 0 | 3 | 1 | 1.83 | .267 | 1.04 | 5.3 | 4.2 | 11.3 | 39.1 | 23 | 8 | 8 | 3 | 18 | 49 | 0 | 6 | 0 | 0 | 0 | 2 | 0 | 3.03 |
| RP | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 82 | 22 | 0 | 2 | 0 | 2.36 | .252 | 1.01 | 6.9 | 2.4 | 8.0 | 26.2 | 20 | 7 | 7 | 3 | 7 | 23 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 3.54 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 74 | 11 | 0 | 2 | 0 | 2.45 | .279 | 1.09 | 7.7 | 2.6 | 7.7 | 14.2 | 12 | 4 | 4 | 0 | 4 | 12 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 2.36 |
| RP | Zimmerman, J.Zimmerman, Jeff >> | 27 | 1999 | R | 66 | 17 | 0 | 1 | 2 | 2.10 | .267 | 0.97 | 6.5 | 2.5 | 6.8 | 25.2 | 18 | 8 | 6 | 1 | 7 | 19 | 0 | 0 | 1 | 0 | 0 | 3 | 1 | 3.20 |