| SP | Greinke, Z.Greinke, Zack >> | 32 | 2015 | R | 94 | 19 | 19 | 5 | 6 | 4.38 | .323 | 1.43 | 9.6 | 3.3 | 7.3 | 121.1 | 129 | 63 | 59 | 8 | 44 | 98 | 2 | 0 | 0 | 1 | 10 | 1 | 3 | 3.36 |
| SP | Lincecum, T.Lincecum, Tim >> | 25 | 2009 | R | 59 | 18 | 18 | 6 | 8 | 5.38 | .356 | 1.61 | 10.6 | 4.0 | 9.2 | 110.1 | 129 | 70 | 66 | 20 | 49 | 112 | 0 | 0 | 0 | 0 | 8 | 5 | 4 | 4.80 |
| SP | Beckett, J.Beckett, Josh >> | 31 | 2011 | R | 58 | 19 | 18 | 3 | 10 | 5.38 | .305 | 1.31 | 9.1 | 2.8 | 6.0 | 108.2 | 109 | 70 | 65 | 18 | 33 | 72 | 3 | 0 | 0 | 0 | 7 | 1 | 5 | 4.78 |
| SP | Mussina, M.Mussina, Mike >> | 33 | 2001 | R | 26 | 20 | 18 | 8 | 6 | 4.34 | .323 | 1.42 | 10.5 | 2.4 | 7.3 | 105.2 | 122 | 55 | 51 | 13 | 28 | 85 | 0 | 0 | 0 | 0 | 13 | 1 | 2 | 3.82 |
| RP | Feliz, N.Feliz, Neftali >> | 21 | 2009 | R | 97 | 52 | 0 | 3 | 2 | 3.55 | .290 | 1.21 | 7.5 | 3.4 | 9.8 | 71.0 | 59 | 29 | 28 | 11 | 27 | 77 | 0 | 5 | 4 | 0 | 0 | 1 | 0 | 4.03 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 77 | 46 | 0 | 3 | 2 | 2.72 | .290 | 1.19 | 6.8 | 3.9 | 8.8 | 53.0 | 40 | 17 | 16 | 6 | 23 | 52 | 0 | 4 | 2 | 0 | 0 | 2 | 0 | 3.92 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 76 | 36 | 0 | 4 | 0 | 4.46 | .353 | 1.59 | 8.1 | 6.3 | 8.8 | 40.1 | 36 | 24 | 20 | 4 | 28 | 39 | 0 | 3 | 0 | 0 | 0 | 2 | 1 | 4.60 |
| RP | Hoffman, T.Hoffman, Trevor >> | 31 | 1998 | R | 72 | 35 | 0 | 5 | 3 | 4.62 | .304 | 1.28 | 7.2 | 4.4 | 7.6 | 39.0 | 31 | 20 | 20 | 1 | 19 | 33 | 0 | 3 | 1 | 0 | 0 | 1 | 2 | 3.18 |
| RP | Harvey, B.Harvey, Bryan >> | 28 | 1991 | R | 62 | 25 | 0 | 1 | 0 | 3.64 | .305 | 1.31 | 7.8 | 4.3 | 7.8 | 29.2 | 25 | 12 | 12 | 7 | 14 | 25 | 0 | 2 | 2 | 0 | 0 | 0 | 0 | 5.86 |