| SP | Martinez, P.Martinez, Pedro >> | 29 | 2000 | R | 100 | 23 | 23 | 8 | 9 | 3.86 | .276 | 1.13 | 7.6 | 2.5 | 8.0 | 168.0 | 142 | 75 | 72 | 17 | 47 | 150 | 5 | 0 | 0 | 1 | 13 | 3 | 5 | 3.42 |
| SP | Kluber, C.Kluber, Corey >> | 31 | 2017 | R | 90 | 22 | 22 | 9 | 9 | 5.01 | .317 | 1.37 | 9.4 | 2.9 | 8.1 | 142.0 | 148 | 81 | 79 | 17 | 46 | 128 | 1 | 0 | 0 | 1 | 9 | 4 | 2 | 3.81 |
| SP | Hernandez, F.Hernandez, Felix >> | 28 | 2014 | R | 80 | 21 | 21 | 4 | 14 | 5.83 | .313 | 1.33 | 9.8 | 2.2 | 7.6 | 126.2 | 137 | 89 | 82 | 24 | 31 | 106 | 1 | 0 | 0 | 0 | 10 | 5 | 8 | 4.65 |
| SP | Waddell, R.Waddell, Rube >> | 29 | 1905 | L | 67 | 22 | 21 | 7 | 11 | 5.34 | .320 | 1.39 | 8.6 | 4.0 | 5.4 | 129.2 | 123 | 79 | 77 | 11 | 57 | 77 | 3 | 0 | 0 | 1 | 9 | 3 | 5 | 4.31 |
| RP | Gallegos, G.Gallegos, Giovanny >> | 27 | 2019 | R | 82 | 52 | 0 | 6 | 2 | 2.94 | .276 | 1.11 | 6.9 | 3.2 | 8.2 | 67.1 | 51 | 24 | 22 | 5 | 24 | 61 | 0 | 0 | 2 | 0 | 0 | 2 | 2 | 3.31 |
| SU | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 88 | 46 | 0 | 1 | 1 | 2.29 | .264 | 1.08 | 8.3 | 1.4 | 7.6 | 51.0 | 47 | 15 | 13 | 2 | 8 | 43 | 0 | 6 | 2 | 0 | 0 | 0 | 0 | 2.29 |
| CL | Wagner, B.Wagner, Billy † >> | 28 | 1999 | L | 95 | 46 | 0 | 1 | 1 | 3.66 | .265 | 1.06 | 5.1 | 4.6 | 10.6 | 51.2 | 29 | 21 | 21 | 3 | 26 | 60 | 0 | 26 | 3 | 0 | 0 | 1 | 1 | 3.00 |
| RP | Clippard, T.Clippard, Tyler >> | 26 | 2011 | R | 79 | 43 | 0 | 5 | 1 | 3.55 | .306 | 1.24 | 7.4 | 4.0 | 7.4 | 50.2 | 41 | 25 | 20 | 5 | 22 | 41 | 0 | 2 | 0 | 0 | 0 | 4 | 1 | 4.22 |
| RP | Zimmerman, J.Zimmerman, Jeff >> | 27 | 1999 | R | 70 | 34 | 0 | 2 | 0 | 3.38 | .310 | 1.32 | 7.0 | 5.0 | 5.2 | 45.1 | 35 | 17 | 17 | 6 | 25 | 26 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 5.31 |