| SP | Johnson, W.Johnson, Walter # >> | 26 | 1913 | R | 95 | 25 | 25 | 9 | 11 | 4.16 | .294 | 1.25 | 9.5 | 1.8 | 4.0 | 179.2 | 188 | 90 | 83 | 18 | 36 | 80 | 6 | 0 | 0 | 0 | 15 | 0 | 1 | 4.02 |
| SP | Kluber, C.Kluber, Corey >> | 31 | 2017 | R | 89 | 25 | 25 | 11 | 9 | 5.25 | .342 | 1.54 | 10.6 | 3.3 | 7.5 | 163.0 | 192 | 97 | 95 | 27 | 59 | 136 | 2 | 0 | 0 | 0 | 10 | 3 | 4 | 4.63 |
| SP | Hernandez, F.Hernandez, Felix >> | 28 | 2014 | R | 79 | 24 | 24 | 5 | 10 | 5.99 | .350 | 1.58 | 10.6 | 3.7 | 7.8 | 133.2 | 156 | 92 | 89 | 27 | 55 | 116 | 0 | 0 | 0 | 0 | 8 | 5 | 7 | 5.25 |
| SP | McLain, D.McLain, Denny >> | 24 | 1968 | R | 78 | 23 | 23 | 5 | 10 | 6.41 | .350 | 1.60 | 10.6 | 3.9 | 5.6 | 133.1 | 156 | 97 | 95 | 24 | 57 | 83 | 2 | 0 | 0 | 1 | 7 | 2 | 3 | 5.43 |
| RP | Benoit, J.Benoit, Joaquin >> | 33 | 2010 | R | 95 | 40 | 0 | 3 | 2 | 2.83 | .280 | 1.17 | 7.7 | 2.8 | 7.4 | 57.1 | 49 | 18 | 18 | 6 | 18 | 47 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 3.67 |
| SU | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 40 | 0 | 0 | 2 | 3.35 | .306 | 1.33 | 8.0 | 4.0 | 9.4 | 43.0 | 38 | 16 | 16 | 1 | 19 | 45 | 0 | 3 | 1 | 0 | 0 | 0 | 0 | 2.53 |
| CL | Jansen, K.Jansen, Kenley >> | 28 | 2016 | R | 97 | 45 | 0 | 1 | 7 | 4.66 | .296 | 1.24 | 8.6 | 2.6 | 8.6 | 48.1 | 46 | 26 | 25 | 4 | 14 | 46 | 0 | 22 | 5 | 0 | 0 | 1 | 1 | 3.10 |
| RP | Boxberger, B.Boxberger, Brad >> | 26 | 2014 | R | 83 | 53 | 0 | 8 | 0 | 5.30 | .336 | 1.52 | 8.5 | 5.1 | 9.2 | 56.0 | 53 | 33 | 33 | 8 | 32 | 57 | 0 | 1 | 1 | 0 | 0 | 0 | 4 | 4.54 |
| RP | Gallegos, G.Gallegos, Giovanny >> | 27 | 2019 | R | 82 | 30 | 0 | 1 | 0 | 4.97 | .321 | 1.39 | 9.2 | 3.3 | 7.6 | 38.0 | 39 | 21 | 21 | 6 | 14 | 32 | 0 | 1 | 0 | 0 | 0 | 1 | 2 | 4.55 |
| RP | Hochevar, L.Hochevar, Luke >> | 30 | 2013 | R | 77 | 44 | 0 | 3 | 3 | 5.47 | .301 | 1.27 | 9.0 | 2.5 | 7.4 | 51.0 | 51 | 31 | 31 | 5 | 14 | 42 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 3.51 |