| SP | Verlander, J.Verlander, Justin >> | 36 | 2019 | R | 99 | 23 | 23 | 12 | 7 | 4.03 | .296 | 1.25 | 8.1 | 3.1 | 8.5 | 145.1 | 131 | 65 | 65 | 20 | 50 | 137 | 2 | 0 | 0 | 0 | 13 | 2 | 3 | 3.98 |
| SP | Nelson, R.Nelson, Roger >> | 28 | 1972 | R | 85 | 21 | 21 | 8 | 7 | 4.53 | .290 | 1.20 | 8.5 | 2.3 | 4.0 | 109.1 | 103 | 58 | 55 | 18 | 28 | 49 | 0 | 0 | 0 | 0 | 8 | 3 | 3 | 5.10 |
| SP | Horlen, J.Horlen, Joe # >> | 27 | 1964 | R | 78 | 21 | 21 | 7 | 9 | 5.49 | .341 | 1.54 | 10.3 | 3.6 | 4.5 | 119.2 | 136 | 82 | 73 | 17 | 48 | 60 | 1 | 0 | 0 | 0 | 8 | 2 | 5 | 5.11 |
| SP | Clemens, R.Clemens, Roger † >> | 24 | 1986 | R | 69 | 21 | 21 | 9 | 7 | 3.73 | .301 | 1.26 | 7.7 | 3.8 | 6.1 | 156.2 | 133 | 74 | 65 | 20 | 65 | 105 | 7 | 0 | 0 | 1 | 13 | 4 | 4 | 4.65 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 99 | 66 | 0 | 3 | 1 | 3.35 | .255 | 1.01 | 7.2 | 2.0 | 8.3 | 78.0 | 62 | 31 | 29 | 15 | 17 | 72 | 0 | 4 | 3 | 0 | 0 | 1 | 3 | 4.35 |
| RP | Boxberger, B.Boxberger, Brad >> | 26 | 2014 | R | 83 | 47 | 0 | 2 | 3 | 4.47 | .317 | 1.39 | 7.6 | 5.0 | 9.4 | 50.1 | 42 | 29 | 25 | 5 | 28 | 52 | 0 | 3 | 1 | 0 | 0 | 0 | 4 | 3.90 |
| RP | Pagan, E.Pagan, Emilio >> | 28 | 2019 | R | 76 | 39 | 0 | 2 | 4 | 5.98 | .322 | 1.38 | 8.3 | 4.3 | 9.2 | 40.2 | 37 | 30 | 27 | 13 | 19 | 41 | 0 | 2 | 2 | 0 | 0 | 2 | 2 | 6.75 |
| RP | Williams, D.Williams, Devin >> | 28 | 2023 | R | 73 | 30 | 0 | 0 | 0 | 3.66 | .333 | 1.47 | 9.3 | 3.9 | 8.7 | 32.0 | 33 | 13 | 13 | 2 | 14 | 31 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 3.28 |
| RP | Holland, G.Holland, Greg >> | 27 | 2013 | R | 72 | 32 | 0 | 3 | 1 | 2.41 | .268 | 1.05 | 6.1 | 3.3 | 10.5 | 41.0 | 28 | 11 | 11 | 4 | 15 | 48 | 0 | 1 | 1 | 0 | 0 | 2 | 0 | 3.17 |