| SP | Koufax, S.Koufax, Sandy >> | 30 | 1965 | L | 97 | 23 | 23 | 9 | 11 | 4.69 | .310 | 1.31 | 8.7 | 3.1 | 8.3 | 167.0 | 161 | 92 | 87 | 21 | 57 | 154 | 9 | 0 | 0 | 0 | 9 | 7 | 4 | 3.94 |
| SP | Schmidt, J.Schmidt, Jason # >> | 30 | 2003 | R | 67 | 21 | 21 | 8 | 6 | 4.96 | .307 | 1.32 | 8.5 | 3.4 | 8.9 | 136.0 | 128 | 78 | 75 | 18 | 51 | 134 | 2 | 0 | 0 | 1 | 9 | 2 | 3 | 3.92 |
| RP | Street, H.Street, Huston >> | 29 | 2012 | R | 96 | 52 | 0 | 4 | 2 | 4.34 | .294 | 1.24 | 8.9 | 2.3 | 8.5 | 66.1 | 65 | 32 | 32 | 12 | 17 | 62 | 0 | 5 | 2 | 0 | 0 | 1 | 2 | 4.30 |
| RP | Betancourt, R.Betancourt, Rafael # >> | 32 | 2007 | R | 77 | 49 | 0 | 1 | 5 | 5.54 | .321 | 1.40 | 10.0 | 2.6 | 7.3 | 65.0 | 72 | 42 | 40 | 14 | 19 | 53 | 0 | 5 | 2 | 0 | 0 | 1 | 0 | 5.09 |
| RP | Harvey, B.Harvey, Bryan >> | 28 | 1991 | R | 66 | 39 | 0 | 2 | 3 | 5.02 | .338 | 1.53 | 9.8 | 4.0 | 10.5 | 43.0 | 47 | 30 | 24 | 10 | 19 | 50 | 0 | 1 | 3 | 0 | 0 | 0 | 3 | 5.02 |
| RP | Urbina, U.Urbina, Ugueth >> | 24 | 1998 | R | 59 | 31 | 0 | 1 | 2 | 3.96 | .306 | 1.32 | 6.5 | 5.5 | 8.8 | 36.1 | 26 | 16 | 16 | 7 | 22 | 35 | 0 | 3 | 3 | 0 | 0 | 0 | 3 | 5.42 |
| RP | Smoltz, J.Smoltz, John >> | 36 | 2003 | R | 51 | 25 | 0 | 2 | 1 | 2.93 | .297 | 1.27 | 7.7 | 4.0 | 8.3 | 27.2 | 23 | 9 | 9 | 2 | 12 | 25 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 3.44 |
| SP | Liriano, F.Liriano, Francisco >> | 23 | 2006 | L | 58 | 1 | 0 | 0 | 0 | 0.00 | .333 | 1.50 | - | - | - | 0.2 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Carlton, S.Carlton, Steve >> | 28 | 1972 | L | 51 | 8 | 0 | 3 | 0 | 1.45 | .325 | 1.45 | 8.5 | 5.0 | 7.5 | 18.2 | 17 | 5 | 3 | 2 | 10 | 15 | 0 | 2 | 0 | 0 | 0 | 0 | 2 | 4.44 |