| SP | Koufax, S.Koufax, Sandy † >> | 30 | 1965 | L | 97 | 33 | 33 | 14 | 12 | 3.85 | .304 | 1.30 | 7.9 | 3.8 | 7.9 | 240.2 | 211 | 115 | 103 | 31 | 101 | 210 | 9 | 0 | 0 | 0 | 20 | 3 | 3 | 4.23 |
| SP | Horlen, J.Horlen, Joe # >> | 27 | 1964 | R | 78 | 32 | 32 | 13 | 12 | 4.66 | .306 | 1.30 | 8.8 | 2.9 | 5.4 | 216.1 | 212 | 119 | 112 | 26 | 69 | 130 | 2 | 0 | 0 | 1 | 16 | 5 | 6 | 4.39 |
| SP | Caldwell, R.Caldwell, Ray >> | 26 | 1914 | R | 64 | 32 | 32 | 7 | 13 | 5.99 | .350 | 1.60 | 10.6 | 3.8 | 4.9 | 189.1 | 223 | 128 | 126 | 26 | 79 | 103 | 1 | 0 | 0 | 0 | 15 | 4 | 0 | 5.02 |
| SP | Overall, O.Overall, Orval >> | 28 | 1909 | R | 57 | 31 | 31 | 10 | 16 | 5.31 | .339 | 1.50 | 9.3 | 4.3 | 4.6 | 211.2 | 217 | 130 | 125 | 33 | 101 | 107 | 7 | 0 | 0 | 0 | 13 | 8 | 6 | 5.57 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 99 | 96 | 0 | 4 | 5 | 4.45 | .278 | 1.15 | 7.6 | 2.8 | 7.7 | 121.1 | 102 | 62 | 60 | 16 | 37 | 104 | 0 | 10 | 7 | 0 | 0 | 1 | 4 | 3.94 |
| RP | Clippard, T.Clippard, Tyler # >> | 26 | 2011 | R | 79 | 70 | 0 | 6 | 4 | 3.70 | .313 | 1.36 | 8.0 | 4.3 | 8.8 | 87.2 | 77 | 40 | 36 | 15 | 42 | 85 | 0 | 9 | 2 | 0 | 0 | 1 | 3 | 4.77 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 64 | 54 | 0 | 2 | 3 | 5.79 | .359 | 1.65 | 8.2 | 6.8 | 8.7 | 65.1 | 59 | 43 | 42 | 13 | 49 | 63 | 0 | 8 | 2 | 0 | 0 | 2 | 3 | 6.02 |