| SP | McNally, D.McNally, Dave >> | 26 | 1968 | L | 96 | 16 | 16 | 9 | 6 | 3.72 | .297 | 1.23 | 7.9 | 3.2 | 5.3 | 128.1 | 113 | 60 | 53 | 16 | 45 | 75 | 6 | 0 | 0 | 1 | 8 | 5 | 1 | 4.63 |
| SP | Drysdale, D.Drysdale, Don >> | 28 | 1964 | R | 59 | 14 | 14 | 5 | 5 | 4.43 | .293 | 1.23 | 8.9 | 2.3 | 4.8 | 103.2 | 102 | 53 | 51 | 15 | 26 | 55 | 7 | 0 | 0 | 1 | 6 | 1 | 3 | 4.61 |
| SP | Liriano, F.Liriano, Francisco >> | 23 | 2006 | L | 58 | 15 | 15 | 1 | 6 | 4.66 | .309 | 1.31 | 8.7 | 3.2 | 7.3 | 65.2 | 63 | 35 | 34 | 12 | 23 | 53 | 0 | 0 | 0 | 0 | 0 | 2 | 6 | 4.92 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 99 | 32 | 0 | 2 | 3 | 3.57 | .292 | 1.24 | 9.0 | 2.2 | 8.2 | 45.1 | 45 | 21 | 18 | 7 | 11 | 41 | 0 | 1 | 3 | 0 | 0 | 0 | 0 | 3.93 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 73 | 35 | 0 | 0 | 5 | 4.91 | .333 | 1.50 | 9.8 | 3.7 | 8.6 | 44.0 | 48 | 27 | 24 | 8 | 18 | 42 | 0 | 4 | 2 | 0 | 0 | 0 | 0 | 4.68 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 64 | 26 | 0 | 1 | 4 | 7.52 | .398 | 1.95 | 10.7 | 7.0 | 7.6 | 32.1 | 38 | 27 | 27 | 8 | 25 | 27 | 0 | 2 | 3 | 0 | 0 | 1 | 2 | 7.00 |
| RP | Russell, J.Russell, Jeff >> | 28 | 1989 | R | 57 | 23 | 0 | 1 | 1 | 2.45 | .287 | 1.21 | 8.3 | 2.9 | 9.4 | 25.2 | 23 | 7 | 7 | 2 | 8 | 26 | 0 | 1 | 1 | 0 | 0 | 0 | 3 | 2.92 |
| SP | Saberhagen, B.Saberhagen, Bret >> | 25 | 1989 | R | 51 | 18 | 0 | 1 | 3 | 1.85 | .277 | 1.15 | 7.1 | 3.2 | 3.4 | 34.0 | 27 | 10 | 7 | 3 | 12 | 13 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 4.44 |