| SP | Kershaw, C.Kershaw, Clayton # >> | 28 | 2016 | L | 99 | 23 | 23 | 7 | 11 | 4.08 | .264 | 1.04 | 8.0 | 1.4 | 8.0 | 176.1 | 157 | 81 | 80 | 25 | 27 | 156 | 9 | 0 | 0 | 1 | 12 | 6 | 5 | 3.64 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 22 | 22 | 8 | 8 | 3.70 | .296 | 1.23 | 8.8 | 2.3 | 9.3 | 158.0 | 154 | 68 | 65 | 23 | 40 | 164 | 2 | 0 | 0 | 1 | 15 | 5 | 1 | 3.67 |
| SP | Hendrix, C.Hendrix, Claude # >> | 25 | 1914 | R | 69 | 21 | 21 | 7 | 8 | 6.19 | .338 | 1.51 | 10.2 | 3.4 | 4.4 | 139.2 | 158 | 97 | 96 | 24 | 53 | 68 | 5 | 0 | 0 | 0 | 6 | 3 | 3 | 5.47 |
| SP | Caldwell, R.Caldwell, Ray >> | 26 | 1914 | R | 64 | 21 | 21 | 10 | 8 | 4.51 | .313 | 1.33 | 8.2 | 3.9 | 4.3 | 135.2 | 123 | 68 | 68 | 14 | 58 | 65 | 1 | 0 | 0 | 0 | 13 | 4 | 2 | 4.76 |
| RP | Gagne, E.Gagne, Eric † >> | 27 | 2003 | R | 98 | 51 | 0 | 6 | 1 | 1.49 | .283 | 1.16 | 5.0 | 5.5 | 11.2 | 66.2 | 37 | 11 | 11 | 0 | 40 | 82 | 0 | 5 | 1 | 0 | 0 | 2 | 2 | 2.42 |
| RP | Rivera, M.Rivera, Mariano † >> | 39 | 2008 | R | 85 | 52 | 0 | 5 | 4 | 2.98 | .260 | 1.03 | 7.9 | 1.4 | 6.7 | 66.1 | 58 | 22 | 22 | 5 | 10 | 49 | 0 | 10 | 2 | 0 | 0 | 2 | 2 | 3.05 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 64 | 31 | 0 | 1 | 2 | 5.18 | .308 | 1.30 | 7.1 | 4.6 | 9.5 | 33.0 | 26 | 19 | 19 | 5 | 17 | 35 | 0 | 3 | 0 | 0 | 0 | 1 | 3 | 4.48 |
| SP | Coveleski, S.Coveleski, Stan >> | 28 | 1917 | R | 62 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Drysdale, D.Drysdale, Don >> | 28 | 1964 | R | 59 | 14 | 0 | 2 | 1 | 3.98 | .365 | 1.72 | 11.3 | 4.5 | 6.8 | 20.1 | 25 | 9 | 9 | 0 | 10 | 15 | 0 | 1 | 2 | 0 | 0 | 0 | 0 | 3.00 |