| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 23 | 23 | 12 | 7 | 3.19 | .265 | 1.07 | 7.7 | 2.0 | 9.5 | 149.2 | 127 | 56 | 53 | 16 | 33 | 158 | 1 | 0 | 0 | 1 | 12 | 2 | 0 | 2.98 |
| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 92 | 23 | 23 | 10 | 9 | 4.86 | .318 | 1.39 | 9.2 | 3.2 | 7.3 | 150.0 | 154 | 84 | 81 | 20 | 54 | 122 | 2 | 0 | 0 | 0 | 11 | 2 | 3 | 4.23 |
| SP | Krause, H.Krause, Harry >> | 21 | 1909 | L | 72 | 21 | 21 | 9 | 5 | 4.69 | .312 | 1.36 | 9.0 | 3.3 | 5.7 | 119.0 | 119 | 63 | 62 | 12 | 43 | 75 | 1 | 0 | 0 | 0 | 13 | 0 | 3 | 4.13 |
| RP | Uehara, K.Uehara, Koji >> | 38 | 2013 | R | 100 | 64 | 0 | 3 | 2 | 2.95 | .247 | 0.98 | 6.3 | 2.5 | 9.4 | 61.0 | 43 | 20 | 20 | 7 | 17 | 64 | 0 | 6 | 1 | 0 | 0 | 0 | 1 | 3.23 |
| RP | Miller, A.Miller, Andrew >> | 29 | 2014 | L | 88 | 64 | 0 | 3 | 3 | 3.34 | .295 | 1.24 | 6.8 | 4.4 | 10.0 | 62.0 | 47 | 23 | 23 | 4 | 30 | 69 | 0 | 6 | 3 | 0 | 0 | 1 | 4 | 3.11 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 78 | 58 | 0 | 0 | 1 | 4.04 | .316 | 1.37 | 9.0 | 3.3 | 8.1 | 49.0 | 49 | 22 | 22 | 7 | 18 | 44 | 0 | 9 | 1 | 0 | 0 | 1 | 6 | 4.22 |