| SP | Verlander, J.Verlander, Justin >> | 36 | 2019 | R | 99 | 33 | 33 | 10 | 13 | 3.74 | .283 | 1.16 | 8.1 | 2.3 | 8.9 | 219.0 | 198 | 95 | 91 | 26 | 57 | 217 | 2 | 0 | 0 | 0 | 21 | 4 | 3 | 3.40 |
| SP | Drysdale, D.Drysdale, Don >> | 28 | 1964 | R | 59 | 18 | 18 | 7 | 10 | 5.18 | .321 | 1.40 | 9.3 | 3.3 | 5.0 | 130.1 | 134 | 77 | 75 | 24 | 48 | 72 | 7 | 0 | 0 | 0 | 3 | 3 | 2 | 5.47 |
| SP | Hunter, C.Hunter, Catfish >> | 26 | 1972 | R | 81 | 32 | 32 | 16 | 9 | 4.53 | .319 | 1.38 | 9.0 | 3.5 | 4.5 | 234.1 | 233 | 123 | 118 | 30 | 91 | 118 | 11 | 0 | 0 | 0 | 15 | 6 | 3 | 4.90 |
| RP | Uehara, K.Uehara, Koji >> | 38 | 2013 | R | 100 | 93 | 0 | 5 | 4 | 3.27 | .257 | 1.04 | 7.1 | 2.2 | 6.8 | 77.0 | 61 | 30 | 28 | 6 | 19 | 58 | 0 | 10 | 2 | 0 | 0 | 0 | 1 | 3.25 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 63 | 0 | 3 | 3 | 3.05 | .279 | 1.15 | 6.2 | 4.1 | 7.7 | 62.0 | 43 | 21 | 21 | 5 | 28 | 53 | 0 | 9 | 4 | 0 | 0 | 1 | 0 | 3.74 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 81 | 40 | 0 | 1 | 2 | 2.41 | .289 | 1.22 | 6.0 | 5.2 | 7.4 | 33.2 | 22 | 14 | 9 | 3 | 19 | 27 | 0 | 4 | 0 | 0 | 0 | 0 | 0 | 4.27 |
| RP | Rhodes, A.Rhodes, Arthur >> | 32 | 2001 | L | 65 | 55 | 0 | 1 | 2 | 3.31 | .300 | 1.26 | 9.3 | 2.3 | 8.7 | 32.2 | 33 | 13 | 12 | 6 | 8 | 31 | 0 | 2 | 0 | 0 | 0 | 1 | 0 | 4.34 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 78 | 80 | 0 | 1 | 3 | 4.61 | .298 | 1.24 | 7.2 | 4.0 | 7.7 | 56.2 | 45 | 32 | 29 | 9 | 25 | 48 | 0 | 7 | 1 | 0 | 0 | 2 | 12 | 4.82 |
| SP | Liriano, F.Liriano, Francisco >> | 23 | 2006 | L | 58 | 14 | 0 | 3 | 1 | 5.40 | .343 | 1.54 | 9.7 | 4.3 | 6.2 | 38.1 | 41 | 24 | 23 | 5 | 18 | 26 | 0 | 0 | 1 | 0 | 0 | 1 | 2 | 4.84 |