| SP | deGrom, J.deGrom, Jacob $ >> | 33 | 2021 | R | 100 | 22 | 22 | 9 | 5 | 2.71 | .249 | 0.97 | 6.8 | 2.0 | 8.5 | 152.2 | 114 | 46 | 46 | 15 | 34 | 144 | 2 | 0 | 0 | 0 | 16 | 4 | 0 | 3.14 |
| SP | Waddell, R.Waddell, Rube >> | 29 | 1905 | L | 67 | 20 | 20 | 6 | 10 | 4.79 | .311 | 1.34 | 8.7 | 3.4 | 5.9 | 135.1 | 131 | 77 | 72 | 21 | 51 | 88 | 4 | 0 | 0 | 1 | 9 | 1 | 0 | 4.87 |
| RP | Capps, C.Capps, Carter >> | 24 | 2015 | R | 84 | 39 | 0 | 4 | 3 | 3.11 | .287 | 1.19 | 7.2 | 3.5 | 6.8 | 46.1 | 37 | 16 | 16 | 4 | 18 | 35 | 0 | 0 | 0 | 0 | 0 | 1 | 3 | 3.85 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 77 | 25 | 0 | 5 | 1 | 6.51 | .362 | 1.66 | 12.7 | 2.7 | 8.7 | 27.2 | 38 | 21 | 20 | 4 | 8 | 26 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 4.00 |
| RP | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 66 | 24 | 0 | 2 | 0 | 3.54 | .257 | 1.04 | 5.5 | 3.9 | 9.3 | 28.0 | 17 | 11 | 11 | 4 | 12 | 29 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 4.07 |
| CL | Street, H.Street, Huston † >> | 29 | 2012 | R | 96 | 37 | 0 | 0 | 0 | 1.41 | .207 | 0.76 | 5.0 | 1.9 | 7.6 | 38.1 | 21 | 6 | 6 | 0 | 8 | 32 | 0 | 26 | 1 | 0 | 0 | 1 | 0 | 2.03 |
| SP | Cueto, J.Cueto, Johnny # >> | 28 | 2014 | R | 75 | 21 | 20 | 10 | 7 | 3.94 | .292 | 1.21 | 7.9 | 3.1 | 7.0 | 141.2 | 123 | 64 | 62 | 16 | 49 | 110 | 2 | 0 | 0 | 1 | 10 | 3 | 4 | 4.02 |