| SP | Verlander, J.Verlander, Justin >> | 36 | 2019 | R | 99 | 31 | 31 | 10 | 13 | 3.65 | .284 | 1.16 | 7.7 | 2.8 | 7.9 | 212.1 | 181 | 87 | 86 | 27 | 65 | 187 | 3 | 0 | 0 | 1 | 19 | 7 | 3 | 3.91 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 29 | 29 | 13 | 7 | 3.55 | .284 | 1.17 | 7.0 | 3.6 | 8.6 | 187.2 | 145 | 79 | 74 | 16 | 74 | 178 | 1 | 0 | 0 | 1 | 21 | 4 | 2 | 3.46 |
| SP | Hernandez, F.Hernandez, Felix >> | 28 | 2014 | R | 80 | 29 | 29 | 12 | 12 | 4.02 | .305 | 1.29 | 8.7 | 2.9 | 7.1 | 185.2 | 179 | 83 | 83 | 21 | 60 | 145 | 2 | 0 | 0 | 1 | 21 | 5 | 6 | 3.96 |
| SP | Carlton, S.Carlton, Steve >> | 28 | 1972 | L | 50 | 18 | 18 | 9 | 7 | 3.12 | .275 | 1.14 | 7.2 | 3.0 | 5.3 | 124.0 | 99 | 47 | 43 | 11 | 42 | 73 | 9 | 0 | 0 | 3 | 12 | 0 | 2 | 3.99 |
| RP | Benoit, J.Benoit, Joaquin # >> | 33 | 2010 | R | 95 | 75 | 0 | 5 | 5 | 4.83 | .333 | 1.47 | 8.8 | 4.5 | 6.2 | 95.0 | 93 | 51 | 51 | 12 | 47 | 65 | 0 | 10 | 5 | 0 | 0 | 2 | 1 | 4.82 |
| RP | Gossage, R.Gossage, Rich >> | 30 | 1981 | R | 90 | 68 | 0 | 4 | 3 | 3.06 | .288 | 1.20 | 6.9 | 4.0 | 7.2 | 82.1 | 63 | 28 | 28 | 10 | 36 | 66 | 0 | 10 | 2 | 0 | 0 | 1 | 4 | 4.33 |
| RP | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 88 | 39 | 0 | 6 | 1 | 1.98 | .247 | 0.97 | 6.9 | 1.8 | 7.9 | 59.0 | 45 | 14 | 13 | 6 | 12 | 52 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 3.22 |
| RP | Bailey, A.Bailey, Andrew >> | 25 | 2009 | R | 66 | 23 | 0 | 1 | 2 | 1.34 | .211 | 0.80 | 4.4 | 3.0 | 10.1 | 33.2 | 16 | 5 | 5 | 1 | 11 | 37 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 2.15 |
| RP | Rhodes, A.Rhodes, Arthur >> | 32 | 2001 | L | 64 | 29 | 0 | 2 | 2 | 3.44 | .295 | 1.23 | 8.5 | 2.8 | 8.8 | 36.2 | 34 | 14 | 14 | 1 | 11 | 35 | 0 | 1 | 0 | 0 | 0 | 1 | 3 | 2.42 |