| SP | deGrom, J.deGrom, Jacob † >> | 33 | 2021 | R | 100 | 32 | 32 | 17 | 7 | 2.49 | .244 | 0.96 | 6.0 | 2.6 | 8.1 | 224.0 | 150 | 64 | 62 | 20 | 65 | 202 | 3 | 0 | 0 | 0 | 25 | 2 | 0 | 3.25 |
| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 93 | 31 | 31 | 18 | 9 | 3.59 | .305 | 1.31 | 8.7 | 3.1 | 7.7 | 208.0 | 200 | 89 | 83 | 18 | 72 | 177 | 3 | 0 | 0 | 2 | 19 | 2 | 8 | 3.49 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 84 | 31 | 31 | 15 | 9 | 3.93 | .290 | 1.22 | 8.2 | 2.8 | 8.0 | 206.0 | 187 | 91 | 90 | 27 | 64 | 182 | 5 | 0 | 0 | 1 | 16 | 2 | 7 | 3.90 |
| SP | Guidry, R.Guidry, Ron † >> | 28 | 1978 | L | 78 | 30 | 30 | 14 | 11 | 3.70 | .281 | 1.16 | 8.0 | 2.4 | 5.5 | 214.1 | 190 | 93 | 88 | 16 | 58 | 131 | 12 | 0 | 0 | 4 | 16 | 3 | 8 | 3.60 |
| RP | Chapman, A.Chapman, Aroldis † >> | 37 | 2025 | L | 96 | 89 | 0 | 4 | 2 | 1.81 | .253 | 1.00 | 5.5 | 3.6 | 8.6 | 84.2 | 51 | 21 | 17 | 5 | 34 | 80 | 0 | 5 | 0 | 0 | 0 | 1 | 4 | 3.12 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 83 | 0 | 2 | 1 | 2.14 | .211 | 0.79 | 6.0 | 1.1 | 7.7 | 67.1 | 45 | 16 | 16 | 4 | 8 | 57 | 0 | 10 | 2 | 0 | 0 | 1 | 1 | 2.48 |
| RP | Hochevar, L.Hochevar, Luke >> | 30 | 2013 | R | 78 | 57 | 0 | 4 | 3 | 3.02 | .282 | 1.18 | 8.3 | 2.4 | 9.9 | 41.2 | 38 | 15 | 14 | 5 | 11 | 45 | 0 | 8 | 3 | 0 | 0 | 0 | 1 | 3.20 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 63 | 34 | 0 | 3 | 2 | 3.20 | .310 | 1.35 | 5.5 | 6.7 | 9.9 | 39.1 | 24 | 17 | 14 | 4 | 29 | 43 | 0 | 3 | 1 | 0 | 0 | 0 | 1 | 4.36 |