| SP | Scherzer, M.Scherzer, Max >> | 33 | 2017 | R | 95 | 22 | 22 | 8 | 7 | 4.78 | .319 | 1.39 | 8.2 | 4.3 | 7.9 | 141.1 | 129 | 81 | 75 | 22 | 68 | 123 | 0 | 0 | 0 | 0 | 11 | 2 | 3 | 4.77 |
| SP | Maddux, G.Maddux, Greg $$ >> | 29 | 1995 | R | 89 | 20 | 20 | 8 | 10 | 4.53 | .294 | 1.22 | 9.0 | 2.0 | 5.3 | 145.0 | 145 | 76 | 73 | 20 | 32 | 86 | 7 | 0 | 0 | 1 | 9 | 4 | 1 | 4.35 |
| SP | Carlton, S.Carlton, Steve >> | 28 | 1972 | L | 51 | 19 | 16 | 4 | 9 | 5.47 | .336 | 1.50 | 9.6 | 3.9 | 4.2 | 125.0 | 133 | 78 | 76 | 18 | 54 | 59 | 4 | 0 | 0 | 0 | 4 | 3 | 1 | 5.30 |
| SP | Darvish, Y.Darvish, Yu # >> | 26 | 2013 | R | 47 | 15 | 15 | 7 | 5 | 5.14 | .320 | 1.38 | 8.2 | 4.2 | 8.6 | 89.1 | 81 | 52 | 51 | 11 | 42 | 85 | 0 | 0 | 0 | 0 | 7 | 3 | 4 | 4.21 |
| SP | Schmidt, J.Schmidt, Jason >> | 30 | 2003 | R | 67 | 18 | 18 | 5 | 8 | 4.18 | .317 | 1.38 | 8.9 | 3.5 | 6.8 | 125.0 | 124 | 63 | 58 | 15 | 49 | 94 | 2 | 0 | 0 | 1 | 10 | 1 | 6 | 4.26 |
| RP | Saito, T.Saito, Takashi >> | 37 | 2007 | R | 91 | 43 | 0 | 2 | 4 | 4.31 | .258 | 0.96 | 6.2 | 2.4 | 8.8 | 48.0 | 33 | 23 | 23 | 10 | 13 | 47 | 0 | 4 | 2 | 0 | 0 | 4 | 0 | 4.81 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 76 | 14 | 0 | 3 | 2 | 6.55 | .411 | 2.00 | 8.2 | 9.8 | 14.7 | 11.0 | 10 | 8 | 8 | 2 | 12 | 18 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 5.64 |
| RP | Bailey, A.Bailey, Andrew >> | 25 | 2009 | R | 66 | 13 | 0 | 0 | 0 | 4.24 | .301 | 1.29 | 9.0 | 2.6 | 5.3 | 17.0 | 17 | 10 | 8 | 2 | 5 | 10 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 4.24 |
| SP | Hendrix, C.Hendrix, Claude # >> | 25 | 1914 | R | 69 | 14 | 8 | 5 | 4 | 3.40 | .280 | 1.16 | 7.7 | 2.8 | 5.3 | 87.1 | 74 | 34 | 33 | 7 | 27 | 51 | 4 | 0 | 0 | 0 | 6 | 1 | 3 | 3.84 |