| SP | Koufax, S.Koufax, Sandy >> | 30 | 1965 | L | 97 | 32 | 32 | 11 | 15 | 4.35 | .296 | 1.24 | 8.2 | 3.0 | 7.8 | 237.2 | 217 | 117 | 115 | 31 | 78 | 205 | 10 | 0 | 0 | 0 | 17 | 5 | 2 | 4.02 |
| SP | Adams, B.Adams, Babe # >> | 27 | 1909 | R | 86 | 31 | 31 | 7 | 11 | 5.92 | .346 | 1.54 | 10.3 | 3.5 | 3.5 | 149.0 | 171 | 103 | 98 | 15 | 58 | 58 | 0 | 0 | 0 | 0 | 8 | 7 | 2 | 4.84 |
| SP | Snell, B.Snell, Blake # >> | 25 | 2018 | L | 81 | 31 | 31 | 8 | 16 | 3.63 | .285 | 1.18 | 7.1 | 3.6 | 9.0 | 190.2 | 150 | 78 | 77 | 13 | 75 | 189 | 0 | 0 | 0 | 0 | 18 | 3 | 9 | 3.13 |
| SP | Coveleski, S.Coveleski, Stan >> | 28 | 1917 | R | 62 | 29 | 29 | 8 | 14 | 4.52 | .332 | 1.48 | 8.4 | 4.9 | 3.7 | 195.0 | 181 | 100 | 98 | 17 | 107 | 80 | 3 | 0 | 0 | 0 | 15 | 3 | 2 | 5.01 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 98 | 83 | 0 | 3 | 6 | 4.45 | .295 | 1.22 | 8.4 | 2.7 | 8.8 | 111.1 | 103 | 55 | 55 | 15 | 33 | 109 | 0 | 7 | 5 | 0 | 0 | 4 | 3 | 3.79 |
| RP | Williams, D.Williams, Devin >> | 28 | 2023 | R | 73 | 68 | 0 | 2 | 3 | 4.56 | .329 | 1.46 | 7.4 | 5.7 | 9.7 | 79.0 | 65 | 40 | 40 | 11 | 50 | 85 | 0 | 2 | 3 | 0 | 0 | 1 | 2 | 4.59 |
| RP | Messersmith, A.Messersmith, Andy >> | 23 | 1968 | R | 57 | 51 | 0 | 3 | 2 | 3.21 | .286 | 1.15 | 5.8 | 4.6 | 4.7 | 84.0 | 54 | 30 | 30 | 7 | 43 | 44 | 0 | 6 | 1 | 0 | 0 | 4 | 4 | 4.71 |
| SP | Camnitz, H.Camnitz, Howie >> | 28 | 1909 | R | 58 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Liriano, F.Liriano, Francisco >> | 23 | 2006 | L | 57 | 24 | 0 | 4 | 2 | 4.54 | .327 | 1.46 | 8.5 | 4.9 | 8.7 | 35.2 | 33 | 20 | 18 | 4 | 19 | 34 | 0 | 2 | 1 | 0 | 0 | 0 | 1 | 4.17 |