| SP | Verlander, J.Verlander, Justin >> | 36 | 2019 | R | 99 | 22 | 22 | 7 | 10 | 4.50 | .327 | 1.44 | 9.3 | 3.7 | 8.7 | 144.0 | 149 | 74 | 72 | 19 | 59 | 139 | 1 | 0 | 0 | 0 | 10 | 2 | 2 | 4.06 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 21 | 21 | 6 | 10 | 5.02 | .339 | 1.50 | 9.2 | 4.3 | 8.0 | 138.0 | 141 | 78 | 77 | 26 | 66 | 123 | 0 | 0 | 0 | 0 | 8 | 5 | 5 | 5.21 |
| SP | Nelson, R.Nelson, Roger >> | 28 | 1972 | R | 84 | 21 | 21 | 2 | 9 | 4.82 | .342 | 1.54 | 9.1 | 4.8 | 4.0 | 108.1 | 109 | 61 | 58 | 17 | 58 | 48 | 0 | 0 | 0 | 0 | 3 | 2 | 2 | 5.82 |
| SP | Bender, C.Bender, Chief >> | 26 | 1910 | R | 71 | 20 | 20 | 6 | 12 | 4.99 | .333 | 1.49 | 10.0 | 3.5 | 4.2 | 148.0 | 164 | 86 | 82 | 19 | 57 | 69 | 4 | 0 | 0 | 0 | 7 | 1 | 4 | 4.91 |
| SP | Caldwell, R.Caldwell, Ray # >> | 26 | 1914 | R | 64 | 20 | 20 | 4 | 11 | 5.62 | .313 | 1.32 | 9.1 | 2.9 | 4.3 | 129.2 | 130 | 85 | 81 | 22 | 41 | 61 | 0 | 0 | 0 | 0 | 8 | 6 | 3 | 5.36 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 99 | 58 | 0 | 4 | 2 | 4.16 | .308 | 1.32 | 8.6 | 3.4 | 8.3 | 75.2 | 72 | 35 | 35 | 9 | 28 | 69 | 0 | 5 | 3 | 0 | 0 | 1 | 1 | 3.88 |
| RP | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 87 | 55 | 0 | 5 | 4 | 5.28 | .302 | 1.25 | 9.2 | 2.1 | 6.4 | 73.1 | 75 | 43 | 43 | 9 | 17 | 52 | 0 | 6 | 6 | 0 | 0 | 3 | 0 | 4.00 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 73 | 45 | 0 | 1 | 1 | 3.31 | .276 | 1.14 | 8.3 | 2.0 | 8.6 | 49.0 | 45 | 19 | 18 | 3 | 11 | 47 | 0 | 3 | 1 | 0 | 0 | 0 | 0 | 2.55 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 62 | 28 | 0 | 1 | 2 | 4.50 | .333 | 1.50 | 6.8 | 6.8 | 8.8 | 36.0 | 27 | 18 | 18 | 4 | 27 | 35 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 4.75 |
| SP | Hendricks, K.Hendricks, Kyle >> | 26 | 2016 | R | 56 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Coveleski, S.Coveleski, Stan >> | 28 | 1917 | R | 62 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Tanana, F.Tanana, Frank >> | 23 | 1976 | L | 58 | 20 | 0 | 4 | 3 | 3.09 | .333 | 1.50 | 11.3 | 2.3 | 6.3 | 23.1 | 29 | 12 | 8 | 3 | 6 | 16 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 4.09 |