| SP | Arrieta, J.Arrieta, Jake † >> | 29 | 2015 | R | 93 | 31 | 31 | 19 | 10 | 2.81 | .269 | 1.07 | 7.3 | 2.3 | 7.3 | 227.0 | 184 | 73 | 71 | 16 | 59 | 183 | 4 | 0 | 0 | 0 | 24 | 7 | 5 | 3.18 |
| SP | Cole, G.Cole, Gerrit # >> | 28 | 2019 | R | 91 | 29 | 29 | 15 | 11 | 3.23 | .262 | 1.04 | 7.4 | 2.0 | 8.2 | 203.2 | 166 | 76 | 73 | 20 | 46 | 186 | 0 | 0 | 0 | 0 | 22 | 5 | 1 | 3.20 |
| SP | Mathewson, C.Mathewson, Christy † $$ >> | 28 | 1908 | R | 82 | 30 | 30 | 16 | 8 | 3.73 | .302 | 1.27 | 9.2 | 2.2 | 4.7 | 214.2 | 219 | 89 | 89 | 20 | 53 | 112 | 6 | 0 | 0 | 2 | 16 | 6 | 1 | 4.00 |
| SP | Ryan, N.Ryan, Nolan $$ >> | 44 | 1991 | R | 73 | 30 | 30 | 10 | 9 | 4.04 | .317 | 1.37 | 8.1 | 4.3 | 8.7 | 191.2 | 171 | 87 | 86 | 16 | 92 | 184 | 2 | 0 | 0 | 1 | 17 | 4 | 7 | 3.67 |
| SP | Reulbach, E.Reulbach, Ed >> | 24 | 1906 | R | 60 | 33 | 24 | 14 | 6 | 4.28 | .318 | 1.38 | 7.8 | 4.7 | 3.5 | 172.1 | 149 | 84 | 82 | 16 | 89 | 66 | 3 | 1 | 1 | 2 | 13 | 3 | 4 | 5.05 |
| RP | Miller, A.Miller, Andrew >> | 29 | 2014 | L | 89 | 83 | 0 | 2 | 3 | 3.81 | .274 | 1.13 | 6.6 | 3.7 | 8.7 | 56.2 | 41 | 24 | 24 | 8 | 23 | 54 | 0 | 4 | 3 | 0 | 0 | 0 | 3 | 4.16 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 79 | 0 | 2 | 2 | 3.40 | .261 | 1.02 | 7.2 | 2.1 | 8.0 | 55.2 | 44 | 21 | 21 | 6 | 13 | 49 | 0 | 2 | 0 | 0 | 0 | 2 | 1 | 3.45 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 75 | 57 | 0 | 2 | 3 | 4.50 | .333 | 1.48 | 7.1 | 6.2 | 10.7 | 42.0 | 33 | 21 | 21 | 2 | 29 | 50 | 0 | 1 | 2 | 0 | 0 | 1 | 1 | 3.38 |
| RP | Messersmith, A.Messersmith, Andy >> | 23 | 1968 | R | 57 | 35 | 0 | 4 | 2 | 3.55 | .318 | 1.40 | 6.8 | 6.0 | 5.0 | 45.2 | 34 | 18 | 18 | 2 | 30 | 25 | 0 | 4 | 0 | 0 | 0 | 0 | 3 | 4.47 |
| SP | Lincecum, T.Lincecum, Tim >> | 25 | 2009 | R | 39 | 5 | 1 | 0 | 3 | 5.63 | .314 | 1.38 | 10.1 | 2.3 | 9.6 | 16.0 | 18 | 10 | 10 | 4 | 4 | 17 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.88 |
| CL | Chapman, A.Chapman, Aroldis † >> | 26 | 2014 | L | 93 | 57 | 0 | 1 | 1 | 1.45 | .273 | 1.13 | 5.1 | 5.1 | 9.6 | 49.2 | 28 | 9 | 8 | 1 | 28 | 52 | 0 | 33 | 2 | 0 | 0 | 0 | 2 | 2.86 |