| SP | Kershaw, C.Kershaw, Clayton >> | 28 | 2016 | L | 99 | 33 | 33 | 17 | 8 | 3.84 | .289 | 1.18 | 9.3 | 1.4 | 8.0 | 206.0 | 213 | 94 | 88 | 14 | 31 | 183 | 3 | 0 | 0 | 0 | 20 | 7 | 9 | 2.66 |
| SP | Kluber, C.Kluber, Corey >> | 31 | 2017 | R | 90 | 33 | 33 | 10 | 13 | 5.94 | .338 | 1.51 | 10.0 | 3.6 | 8.6 | 185.0 | 206 | 127 | 122 | 30 | 73 | 177 | 1 | 0 | 0 | 0 | 12 | 4 | 0 | 4.44 |
| SP | Santana, J.Santana, Johan # >> | 25 | 2004 | L | 86 | 32 | 32 | 14 | 13 | 4.80 | .311 | 1.32 | 9.5 | 2.5 | 8.4 | 183.2 | 193 | 105 | 98 | 22 | 50 | 171 | 0 | 0 | 0 | 0 | 19 | 6 | 4 | 3.61 |
| SP | Snell, B.Snell, Blake # >> | 25 | 2018 | L | 81 | 32 | 32 | 14 | 8 | 4.55 | .306 | 1.30 | 8.4 | 3.3 | 8.8 | 176.0 | 164 | 95 | 89 | 17 | 64 | 173 | 1 | 0 | 0 | 0 | 16 | 5 | 6 | 3.47 |
| SP | Guidry, R.Guidry, Ron # >> | 28 | 1978 | L | 78 | 30 | 29 | 13 | 8 | 4.67 | .333 | 1.47 | 9.5 | 3.8 | 6.0 | 188.2 | 198 | 103 | 98 | 19 | 79 | 125 | 6 | 0 | 0 | 1 | 13 | 6 | 6 | 4.34 |
| CL | Kimbrel, C.Kimbrel, Craig † >> | 24 | 2012 | R | 100 | 72 | 0 | 7 | 3 | 3.86 | .296 | 1.26 | 6.9 | 4.5 | 8.8 | 74.2 | 57 | 36 | 32 | 6 | 37 | 72 | 0 | 28 | 7 | 0 | 0 | 0 | 7 | 3.61 |
| SU | Gossage, R.Gossage, Rich >> | 30 | 1981 | R | 90 | 76 | 0 | 1 | 2 | 4.65 | .306 | 1.32 | 8.0 | 3.9 | 8.8 | 93.0 | 83 | 50 | 48 | 15 | 40 | 91 | 0 | 6 | 4 | 0 | 0 | 0 | 3 | 4.43 |
| RP | Boxberger, B.Boxberger, Brad >> | 26 | 2014 | R | 83 | 85 | 0 | 4 | 4 | 5.85 | .347 | 1.59 | 9.8 | 4.6 | 10.4 | 87.2 | 95 | 59 | 57 | 11 | 44 | 101 | 0 | 1 | 7 | 0 | 0 | 1 | 3 | 3.87 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 81 | 77 | 0 | 6 | 3 | 3.89 | .314 | 1.36 | 8.8 | 3.4 | 9.1 | 81.0 | 79 | 36 | 35 | 11 | 31 | 82 | 0 | 2 | 1 | 0 | 0 | 1 | 0 | 3.93 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 74 | 59 | 0 | 3 | 1 | 4.60 | .315 | 1.38 | 8.4 | 4.1 | 9.1 | 72.1 | 67 | 39 | 37 | 6 | 33 | 73 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 3.43 |
| RP | Holland, G.Holland, Greg >> | 27 | 2013 | R | 72 | 45 | 0 | 4 | 3 | 4.12 | .326 | 1.41 | 9.9 | 2.9 | 10.9 | 63.1 | 69 | 32 | 29 | 9 | 20 | 76 | 0 | 1 | 0 | 0 | 0 | 3 | 0 | 3.54 |