| SP | Kershaw, C.Kershaw, Clayton >> | 28 | 2016 | L | 99 | 18 | 18 | 8 | 2 | 3.38 | .261 | 1.03 | 7.1 | 2.2 | 7.3 | 117.0 | 92 | 47 | 44 | 9 | 29 | 95 | 5 | 0 | 0 | 2 | 12 | 3 | 4 | 3.20 |
| SP | Arrieta, J.Arrieta, Jake # >> | 29 | 2015 | R | 92 | 18 | 17 | 6 | 3 | 5.01 | .306 | 1.31 | 8.9 | 3.0 | 8.1 | 91.2 | 90 | 52 | 51 | 11 | 30 | 82 | 1 | 0 | 0 | 0 | 8 | 1 | 0 | 3.79 |
| SP | Hernandez, F.Hernandez, Felix >> | 28 | 2014 | R | 80 | 17 | 17 | 5 | 10 | 5.17 | .314 | 1.38 | 9.7 | 2.7 | 8.9 | 92.1 | 99 | 53 | 53 | 14 | 28 | 91 | 0 | 0 | 0 | 0 | 11 | 0 | 7 | 3.91 |
| SP | Fernandez, J.Fernandez, Jose >> | 21 | 2013 | R | 76 | 19 | 17 | 6 | 4 | 7.30 | .381 | 1.84 | 12.2 | 4.4 | 8.2 | 81.1 | 110 | 70 | 66 | 19 | 40 | 74 | 0 | 1 | 0 | 0 | 3 | 0 | 2 | 5.70 |
| SP | Schmidt, J.Schmidt, Jason # >> | 30 | 2003 | R | 67 | 17 | 16 | 7 | 3 | 5.25 | .332 | 1.48 | 10.1 | 3.4 | 6.8 | 85.2 | 95 | 51 | 50 | 9 | 32 | 64 | 0 | 0 | 0 | 0 | 7 | 1 | 2 | 4.04 |
| CL | Kimbrel, C.Kimbrel, Craig † $ >> | 24 | 2012 | R | 100 | 52 | 0 | 5 | 3 | 2.43 | .287 | 1.19 | 6.7 | 4.0 | 10.1 | 63.0 | 47 | 18 | 17 | 3 | 28 | 71 | 0 | 20 | 1 | 0 | 0 | 1 | 4 | 2.75 |
| SU | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 54 | 0 | 1 | 3 | 4.01 | .311 | 1.32 | 7.4 | 4.7 | 9.5 | 60.2 | 49 | 31 | 27 | 10 | 31 | 63 | 0 | 0 | 8 | 0 | 0 | 2 | 0 | 4.72 |
| RP | Saito, T.Saito, Takashi >> | 37 | 2007 | R | 90 | 48 | 0 | 1 | 2 | 4.29 | .300 | 1.29 | 8.4 | 3.4 | 7.7 | 56.2 | 52 | 28 | 27 | 8 | 21 | 48 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 4.27 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 35 | 0 | 8 | 3 | 5.67 | .302 | 1.28 | 9.2 | 2.3 | 9.5 | 54.0 | 55 | 35 | 34 | 6 | 14 | 57 | 0 | 0 | 0 | 0 | 0 | 1 | 3 | 3.17 |