| SP | Kershaw, C.Kershaw, Clayton † >> | 28 | 2016 | L | 99 | 34 | 34 | 19 | 8 | 4.00 | .298 | 1.25 | 9.2 | 2.1 | 7.9 | 245.1 | 250 | 118 | 109 | 31 | 57 | 215 | 3 | 0 | 0 | 0 | 20 | 5 | 4 | 3.65 |
| SP | Maddux, G.Maddux, Greg † >> | 29 | 1995 | R | 89 | 33 | 33 | 19 | 7 | 3.03 | .295 | 1.24 | 8.8 | 2.3 | 5.4 | 237.2 | 233 | 93 | 80 | 14 | 61 | 142 | 3 | 0 | 0 | 1 | 26 | 4 | 4 | 3.39 |
| SP | Johnson, R.Johnson, Randy # >> | 41 | 2004 | L | 84 | 32 | 32 | 7 | 17 | 6.54 | .358 | 1.65 | 11.1 | 3.8 | 7.6 | 199.2 | 246 | 155 | 145 | 32 | 83 | 169 | 2 | 0 | 0 | 0 | 9 | 5 | 3 | 4.72 |
| SP | Sutton, D.Sutton, Don # >> | 27 | 1972 | R | 82 | 32 | 32 | 7 | 16 | 6.03 | .340 | 1.52 | 10.0 | 3.7 | 5.3 | 207.1 | 230 | 153 | 139 | 26 | 85 | 123 | 3 | 0 | 0 | 1 | 11 | 6 | 7 | 4.76 |
| SP | Cueto, J.Cueto, Johnny # >> | 28 | 2014 | R | 75 | 31 | 31 | 9 | 16 | 6.08 | .362 | 1.66 | 10.5 | 4.5 | 5.5 | 198.1 | 232 | 144 | 134 | 31 | 98 | 122 | 2 | 0 | 0 | 1 | 9 | 8 | 3 | 5.41 |
| CL | Kuo, H.Kuo, Hong-Chih # >> | 29 | 2010 | L | 91 | 80 | 0 | 4 | 3 | 4.38 | .288 | 1.20 | 7.5 | 3.4 | 9.9 | 61.2 | 51 | 32 | 30 | 7 | 23 | 67 | 0 | 10 | 2 | 0 | 0 | 1 | 3 | 3.48 |
| SU | Gallegos, G.Gallegos, Giovanny # >> | 27 | 2019 | R | 82 | 88 | 0 | 3 | 5 | 4.79 | .319 | 1.39 | 9.0 | 3.6 | 8.7 | 67.2 | 67 | 40 | 36 | 11 | 27 | 65 | 0 | 0 | 2 | 0 | 0 | 1 | 4 | 4.45 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 73 | 55 | 0 | 2 | 1 | 4.68 | .298 | 1.22 | 8.7 | 2.4 | 8.5 | 59.2 | 57 | 32 | 31 | 9 | 16 | 56 | 0 | 2 | 0 | 0 | 0 | 3 | 0 | 4.05 |
| RP | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 69 | 52 | 0 | 3 | 2 | 2.22 | .274 | 1.06 | 6.4 | 3.2 | 8.0 | 56.2 | 40 | 14 | 14 | 6 | 20 | 50 | 0 | 2 | 0 | 0 | 0 | 4 | 0 | 3.89 |
| RP | Wagner, B.Wagner, Billy >> | 28 | 1999 | L | 95 | 62 | 0 | 2 | 9 | 3.04 | .279 | 1.16 | 7.4 | 3.0 | 9.4 | 68.0 | 56 | 27 | 23 | 8 | 23 | 71 | 0 | 26 | 5 | 0 | 0 | 0 | 2 | 3.46 |