| SP | deGrom, J.deGrom, Jacob † >> | 33 | 2021 | R | 100 | 24 | 24 | 14 | 6 | 3.14 | .267 | 1.08 | 7.1 | 2.8 | 8.0 | 157.2 | 123 | 58 | 55 | 17 | 48 | 139 | 0 | 0 | 0 | 0 | 17 | 1 | 0 | 3.57 |
| SP | Koufax, S.Koufax, Sandy # >> | 30 | 1965 | L | 98 | 23 | 23 | 10 | 7 | 4.40 | .296 | 1.25 | 8.5 | 2.7 | 8.9 | 145.1 | 137 | 75 | 71 | 24 | 44 | 143 | 2 | 0 | 0 | 2 | 11 | 2 | 4 | 4.13 |
| SP | Nelson, R.Nelson, Roger >> | 28 | 1972 | R | 84 | 22 | 22 | 8 | 7 | 4.45 | .305 | 1.31 | 8.3 | 3.6 | 5.0 | 109.1 | 100 | 60 | 54 | 18 | 43 | 61 | 0 | 0 | 0 | 0 | 6 | 1 | 2 | 5.24 |
| SP | Hernandez, F.Hernandez, Felix >> | 28 | 2014 | R | 79 | 24 | 22 | 3 | 14 | 7.38 | .372 | 1.76 | 12.4 | 3.5 | 7.8 | 107.1 | 147 | 94 | 88 | 22 | 42 | 93 | 0 | 0 | 0 | 0 | 4 | 2 | 8 | 5.17 |
| RP | Kimbrel, C.Kimbrel, Craig >> | 24 | 2012 | R | 100 | 64 | 0 | 3 | 2 | 3.03 | .284 | 1.17 | 5.7 | 4.9 | 10.6 | 89.0 | 56 | 36 | 30 | 6 | 48 | 105 | 0 | 8 | 6 | 0 | 0 | 2 | 1 | 3.20 |
| RP | Adams, M.Adams, Mike † >> | 31 | 2009 | R | 99 | 59 | 0 | 2 | 1 | 2.94 | .284 | 1.17 | 6.3 | 4.3 | 7.9 | 79.2 | 55 | 34 | 26 | 10 | 38 | 69 | 0 | 5 | 1 | 0 | 0 | 2 | 2 | 4.42 |
| RP | Feliz, N.Feliz, Neftali >> | 21 | 2009 | R | 97 | 53 | 0 | 3 | 6 | 3.05 | .265 | 1.06 | 5.5 | 4.1 | 9.9 | 62.0 | 38 | 22 | 21 | 7 | 28 | 68 | 0 | 3 | 2 | 0 | 0 | 1 | 0 | 3.68 |
| RP | Street, H.Street, Huston >> | 29 | 2012 | R | 96 | 49 | 0 | 2 | 3 | 2.63 | .317 | 1.37 | 7.8 | 4.7 | 10.5 | 54.2 | 47 | 26 | 16 | 6 | 28 | 63 | 0 | 4 | 2 | 0 | 0 | 1 | 1 | 3.72 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 34 | 0 | 2 | 2 | 2.98 | .302 | 1.28 | 7.3 | 4.3 | 9.2 | 42.1 | 34 | 16 | 14 | 5 | 20 | 43 | 0 | 5 | 0 | 0 | 0 | 1 | 0 | 4.00 |