| SP | Leonard, D.Leonard, Dutch >> | 22 | 1914 | L | 91 | 24 | 24 | 7 | 10 | 3.67 | .285 | 1.18 | 7.5 | 3.1 | 5.3 | 152.0 | 126 | 68 | 62 | 11 | 53 | 89 | 3 | 0 | 0 | 2 | 16 | 3 | 2 | 3.88 |
| SP | Maddux, G.Maddux, Greg >> | 29 | 1995 | R | 89 | 23 | 23 | 4 | 12 | 4.09 | .277 | 1.13 | 8.2 | 2.0 | 4.8 | 145.1 | 132 | 69 | 66 | 22 | 32 | 78 | 3 | 0 | 0 | 1 | 13 | 3 | 2 | 4.62 |
| SP | Mathewson, C.Mathewson, Christy >> | 28 | 1908 | R | 83 | 22 | 22 | 7 | 7 | 3.77 | .270 | 1.10 | 8.3 | 1.6 | 3.9 | 143.1 | 132 | 63 | 60 | 18 | 25 | 62 | 3 | 0 | 0 | 2 | 12 | 2 | 0 | 4.34 |
| SP | Waddell, R.Waddell, Rube >> | 29 | 1905 | L | 67 | 23 | 22 | 6 | 12 | 4.73 | .330 | 1.46 | 9.8 | 3.4 | 5.1 | 140.2 | 153 | 78 | 74 | 23 | 53 | 79 | 3 | 0 | 0 | 0 | 11 | 2 | 4 | 5.19 |
| RP | Wilhelm, H.Wilhelm, Hoyt >> | 43 | 1965 | R | 68 | 66 | 0 | 7 | 5 | 3.52 | .284 | 1.16 | 7.6 | 2.9 | 6.1 | 122.2 | 103 | 48 | 48 | 18 | 39 | 83 | 0 | 7 | 1 | 0 | 0 | 4 | 4 | 4.61 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 75 | 46 | 0 | 4 | 1 | 2.28 | .242 | 0.94 | 4.6 | 3.9 | 7.9 | 67.0 | 34 | 17 | 17 | 7 | 29 | 59 | 0 | 3 | 2 | 0 | 0 | 1 | 0 | 3.94 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 80 | 37 | 0 | 3 | 2 | 2.44 | .300 | 1.26 | 8.2 | 3.3 | 6.1 | 44.1 | 40 | 14 | 12 | 5 | 16 | 30 | 0 | 3 | 2 | 0 | 0 | 1 | 0 | 4.27 |
| RP | Messersmith, A.Messersmith, Andy >> | 23 | 1968 | R | 57 | 30 | 0 | 4 | 1 | 3.51 | .301 | 1.27 | 6.9 | 4.7 | 4.5 | 48.2 | 37 | 21 | 19 | 3 | 25 | 24 | 0 | 3 | 1 | 0 | 0 | 1 | 3 | 4.44 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 71 | 19 | 0 | 1 | 3 | 2.93 | .284 | 1.19 | 3.7 | 7.3 | 8.7 | 27.2 | 11 | 11 | 9 | 0 | 22 | 26 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 3.52 |