| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 92 | 12 | 12 | 4 | 5 | 3.23 | .246 | 0.97 | 6.6 | 2.2 | 7.8 | 83.2 | 61 | 30 | 30 | 10 | 20 | 72 | 3 | 0 | 0 | 1 | 9 | 1 | 1 | 3.59 |
| SP | Leonard, D.Leonard, Dutch >> | 22 | 1914 | L | 91 | 12 | 12 | 5 | 3 | 3.03 | .288 | 1.17 | 6.9 | 3.6 | 5.8 | 74.1 | 57 | 25 | 25 | 5 | 30 | 48 | 1 | 0 | 0 | 1 | 9 | 3 | 0 | 3.92 |
| SP | Mathewson, C.Mathewson, Christy >> | 28 | 1908 | R | 83 | 11 | 11 | 3 | 5 | 4.33 | .331 | 1.46 | 11.3 | 1.9 | 4.8 | 70.2 | 88 | 40 | 34 | 10 | 15 | 37 | 0 | 0 | 0 | 0 | 5 | 2 | 2 | 4.53 |
| SP | Fernandez, J.Fernandez, Jose >> | 21 | 2013 | R | 76 | 11 | 11 | 5 | 2 | 5.28 | .330 | 1.46 | 9.6 | 3.7 | 9.3 | 59.2 | 63 | 36 | 35 | 7 | 24 | 61 | 0 | 0 | 0 | 0 | 6 | 1 | 1 | 3.75 |
| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 61 | 12 | 11 | 2 | 5 | 8.08 | .395 | 1.96 | 11.6 | 6.2 | 8.4 | 42.1 | 54 | 41 | 38 | 7 | 29 | 39 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 5.38 |
| RP | Benitez, A.Benitez, Armando >> | 32 | 2004 | R | 82 | 39 | 0 | 3 | 4 | 3.66 | .289 | 1.22 | 6.4 | 4.8 | 4.6 | 51.2 | 36 | 21 | 21 | 4 | 27 | 26 | 0 | 1 | 2 | 0 | 0 | 0 | 0 | 4.59 |
| RP | Clippard, T.Clippard, Tyler >> | 26 | 2011 | R | 79 | 35 | 0 | 1 | 1 | 2.57 | .226 | 0.88 | 4.0 | 3.9 | 7.2 | 49.0 | 22 | 14 | 14 | 7 | 21 | 39 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 4.55 |
| RP | Balfour, G.Balfour, Grant # >> | 31 | 2008 | R | 76 | 27 | 0 | 4 | 1 | 5.73 | .347 | 1.57 | 8.0 | 6.3 | 8.8 | 37.2 | 33 | 24 | 24 | 8 | 26 | 36 | 0 | 4 | 1 | 0 | 0 | 1 | 0 | 6.05 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 71 | 22 | 0 | 0 | 2 | 4.24 | .293 | 1.20 | 5.9 | 5.1 | 7.4 | 23.1 | 15 | 12 | 11 | 4 | 13 | 19 | 0 | 2 | 1 | 0 | 0 | 1 | 1 | 5.43 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 64 | 14 | 0 | 0 | 2 | 5.71 | .395 | 1.90 | 10.1 | 7.4 | 5.8 | 17.1 | 19 | 11 | 11 | 4 | 14 | 11 | 0 | 2 | 1 | 0 | 0 | 1 | 1 | 7.41 |