| SP | Tiant, L.Tiant, Luis † # >> | 28 | 1968 | R | 97 | 26 | 26 | 15 | 7 | 3.47 | .289 | 1.20 | 7.4 | 3.4 | 8.6 | 187.0 | 154 | 84 | 72 | 22 | 71 | 178 | 4 | 0 | 0 | 0 | 15 | 3 | 6 | 3.81 |
| SP | Kluber, C.Kluber, Corey # >> | 31 | 2017 | R | 90 | 26 | 26 | 7 | 9 | 4.56 | .312 | 1.34 | 8.9 | 3.2 | 8.4 | 169.2 | 168 | 93 | 86 | 28 | 60 | 157 | 1 | 0 | 0 | 0 | 13 | 3 | 3 | 4.41 |
| SP | Santana, J.Santana, Johan # >> | 25 | 2004 | L | 86 | 25 | 25 | 9 | 9 | 4.53 | .303 | 1.28 | 8.2 | 3.4 | 8.2 | 145.0 | 132 | 77 | 73 | 16 | 54 | 132 | 1 | 0 | 0 | 1 | 9 | 3 | 3 | 3.79 |
| SP | Hunter, C.Hunter, Catfish >> | 26 | 1972 | R | 81 | 24 | 24 | 9 | 10 | 6.13 | .345 | 1.54 | 10.3 | 3.6 | 4.3 | 149.2 | 171 | 105 | 102 | 22 | 60 | 71 | 4 | 0 | 0 | 1 | 9 | 5 | 3 | 5.28 |
| CL | Gagne, E.Gagne, Eric † >> | 27 | 2003 | R | 98 | 53 | 0 | 6 | 3 | 2.67 | .289 | 1.15 | 4.7 | 5.7 | 8.7 | 54.0 | 28 | 16 | 16 | 4 | 34 | 52 | 0 | 30 | 1 | 0 | 0 | 4 | 1 | 4.15 |
| SU | Chapman, A.Chapman, Aroldis >> | 26 | 2014 | L | 94 | 48 | 0 | 2 | 3 | 3.60 | .299 | 1.28 | 6.3 | 5.2 | 8.6 | 50.0 | 35 | 22 | 20 | 8 | 29 | 48 | 0 | 0 | 7 | 0 | 0 | 0 | 2 | 4.90 |
| RP | Benitez, A.Benitez, Armando >> | 32 | 2004 | R | 82 | 48 | 0 | 0 | 1 | 0.95 | .224 | 0.82 | 4.0 | 3.4 | 6.3 | 47.1 | 21 | 5 | 5 | 1 | 18 | 33 | 0 | 3 | 0 | 0 | 0 | 2 | 0 | 3.15 |
| RP | Clippard, T.Clippard, Tyler >> | 26 | 2011 | R | 79 | 27 | 0 | 2 | 2 | 1.80 | .262 | 1.07 | 6.6 | 3.0 | 9.3 | 30.0 | 22 | 6 | 6 | 4 | 10 | 31 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.67 |