| SP | Kershaw, C.Kershaw, Clayton >> | 28 | 2016 | L | 99 | 24 | 24 | 9 | 9 | 4.13 | .283 | 1.15 | 8.3 | 2.1 | 7.5 | 165.2 | 153 | 79 | 76 | 24 | 38 | 137 | 3 | 0 | 0 | 1 | 14 | 5 | 5 | 4.01 |
| SP | Johnson, W.Johnson, Walter † >> | 26 | 1913 | R | 95 | 23 | 23 | 13 | 6 | 2.01 | .244 | 0.96 | 6.8 | 1.9 | 5.2 | 178.2 | 135 | 42 | 40 | 10 | 37 | 103 | 4 | 0 | 0 | 1 | 18 | 1 | 0 | 3.21 |
| SP | Kluber, C.Kluber, Corey >> | 31 | 2017 | R | 89 | 23 | 23 | 12 | 9 | 4.29 | .299 | 1.24 | 8.4 | 2.8 | 7.8 | 153.0 | 142 | 79 | 73 | 22 | 48 | 132 | 2 | 0 | 0 | 0 | 14 | 6 | 2 | 4.20 |
| SP | Santana, J.Santana, Johan # >> | 25 | 2004 | L | 86 | 22 | 22 | 9 | 10 | 5.03 | .306 | 1.30 | 9.6 | 2.1 | 7.6 | 132.1 | 141 | 81 | 74 | 29 | 31 | 111 | 0 | 0 | 0 | 0 | 11 | 3 | 3 | 4.95 |
| SP | Sutton, D.Sutton, Don # >> | 27 | 1972 | R | 82 | 22 | 22 | 11 | 7 | 4.56 | .295 | 1.25 | 8.8 | 2.5 | 5.7 | 146.0 | 142 | 77 | 74 | 14 | 40 | 92 | 5 | 0 | 0 | 1 | 12 | 1 | 0 | 3.83 |
| CL | Uehara, K.Uehara, Koji † >> | 38 | 2013 | R | 100 | 43 | 0 | 1 | 5 | 3.38 | .290 | 1.18 | 7.7 | 2.9 | 7.7 | 40.0 | 34 | 16 | 15 | 8 | 13 | 34 | 0 | 28 | 2 | 0 | 0 | 2 | 1 | 5.03 |
| SU | Benoit, J.Benoit, Joaquin >> | 33 | 2010 | R | 95 | 46 | 0 | 2 | 2 | 2.77 | .247 | 0.97 | 4.9 | 3.9 | 9.0 | 48.2 | 26 | 16 | 15 | 4 | 21 | 48 | 0 | 4 | 4 | 0 | 0 | 1 | 0 | 3.46 |
| RP | Miller, A.Miller, Andrew >> | 29 | 2014 | L | 88 | 52 | 0 | 2 | 1 | 4.34 | .287 | 1.21 | 8.0 | 2.9 | 11.7 | 37.1 | 33 | 18 | 18 | 6 | 12 | 48 | 0 | 3 | 1 | 0 | 0 | 0 | 2 | 3.49 |
| RP | Treinen, B.Treinen, Blake >> | 30 | 2018 | R | 79 | 48 | 0 | 2 | 1 | 1.54 | .255 | 1.00 | 5.7 | 3.3 | 8.6 | 41.0 | 26 | 7 | 7 | 2 | 15 | 39 | 0 | 0 | 2 | 0 | 0 | 1 | 0 | 2.90 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 78 | 35 | 0 | 0 | 1 | 4.63 | .291 | 1.20 | 8.0 | 2.8 | 8.5 | 35.0 | 31 | 21 | 18 | 4 | 11 | 33 | 0 | 1 | 0 | 0 | 0 | 1 | 6 | 3.63 |
| SP | Clemens, R.Clemens, Roger >> | 24 | 1986 | R | 69 | 12 | 0 | 0 | 2 | 5.15 | .333 | 1.50 | 10.0 | 3.8 | 4.5 | 36.2 | 40 | 22 | 21 | 5 | 15 | 18 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 5.06 |