| SP | Kluber, C.Kluber, Corey >> | 31 | 2017 | R | 95 | 34 | 34 | 12 | 12 | 5.17 | .324 | 1.42 | 10.2 | 2.6 | 10.2 | 230.0 | 260 | 137 | 132 | 37 | 66 | 261 | 3 | 0 | 0 | 0 | 15 | 4 | 9 | 3.73 |
| SP | Liriano, F.Liriano, Francisco >> | 23 | 2006 | L | 74 | 32 | 32 | 8 | 8 | 5.75 | .353 | 1.61 | 10.7 | 3.7 | 9.0 | 161.1 | 192 | 109 | 103 | 33 | 67 | 161 | 0 | 0 | 0 | 0 | 4 | 5 | 7 | 5.01 |
| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 68 | 32 | 32 | 17 | 8 | 3.84 | .309 | 1.33 | 7.9 | 4.1 | 9.6 | 206.0 | 180 | 96 | 88 | 23 | 93 | 220 | 0 | 0 | 0 | 0 | 20 | 3 | 3 | 3.71 |
| CL | Edwards, C.Edwards, Carl † >> | 24 | 2016 | R | 93 | 71 | 0 | 5 | 13 | 5.13 | .323 | 1.42 | 6.5 | 6.3 | 10.3 | 72.0 | 52 | 41 | 41 | 11 | 50 | 82 | 0 | 39 | 6 | 0 | 0 | 1 | 4 | 4.83 |
| RP | Saito, T.Saito, Takashi >> | 37 | 2007 | R | 90 | 81 | 0 | 3 | 5 | 3.49 | .280 | 1.16 | 7.4 | 3.2 | 9.2 | 105.2 | 86 | 41 | 41 | 17 | 37 | 107 | 0 | 0 | 4 | 0 | 0 | 0 | 0 | 4.12 |
| RP | Boxberger, B.Boxberger, Brad >> | 26 | 2014 | R | 81 | 71 | 0 | 6 | 4 | 3.49 | .329 | 1.46 | 8.6 | 4.6 | 10.5 | 77.1 | 74 | 31 | 30 | 12 | 39 | 90 | 0 | 2 | 2 | 0 | 0 | 1 | 5 | 4.25 |
| RP | Pagan, E.Pagan, Emilio >> | 28 | 2019 | R | 72 | 61 | 0 | 4 | 0 | 3.73 | .315 | 1.38 | 10.6 | 1.9 | 10.1 | 72.1 | 85 | 33 | 30 | 13 | 15 | 81 | 0 | 1 | 0 | 0 | 0 | 0 | 2 | 3.72 |
| RP | Holland, G.Holland, Greg >> | 27 | 2013 | R | 69 | 41 | 0 | 5 | 1 | 2.36 | .297 | 1.27 | 6.6 | 5.0 | 10.6 | 45.2 | 33 | 13 | 12 | 3 | 25 | 53 | 0 | 1 | 0 | 0 | 0 | 0 | 3 | 3.18 |
| RP | Hochevar, L.Hochevar, Luke >> | 30 | 2013 | R | 75 | 38 | 0 | 3 | 0 | 5.94 | .339 | 1.49 | 9.0 | 4.5 | 8.3 | 36.1 | 36 | 24 | 24 | 6 | 18 | 33 | 0 | 0 | 1 | 0 | 0 | 2 | 1 | 5.00 |
| SU | Benoit, J.Benoit, Joaquin >> | 33 | 2010 | R | 94 | 62 | 0 | 2 | 2 | 3.84 | .311 | 1.32 | 9.1 | 2.9 | 9.6 | 65.2 | 66 | 28 | 28 | 6 | 21 | 69 | 0 | 7 | 8 | 0 | 0 | 2 | 1 | 3.14 |