| SP | deGrom, J.deGrom, Jacob † >> | 33 | 2021 | R | 100 | 34 | 34 | 20 | 9 | 2.76 | .266 | 1.06 | 7.8 | 1.8 | 10.7 | 231.2 | 201 | 76 | 71 | 26 | 45 | 275 | 1 | 0 | 0 | 0 | 25 | 6 | 0 | 2.74 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 91 | 33 | 33 | 11 | 17 | 4.54 | .320 | 1.39 | 9.1 | 3.4 | 8.5 | 212.1 | 214 | 114 | 107 | 33 | 81 | 201 | 2 | 0 | 0 | 0 | 15 | 5 | 4 | 4.34 |
| SP | Gallen, Z.Gallen, Zac † >> | 26 | 2022 | R | 92 | 32 | 32 | 13 | 9 | 3.08 | .284 | 1.18 | 7.7 | 2.9 | 7.4 | 210.2 | 180 | 77 | 72 | 20 | 68 | 173 | 2 | 0 | 0 | 1 | 21 | 3 | 4 | 3.60 |
| SP | Schmidt, J.Schmidt, Jason >> | 30 | 2003 | R | 78 | 32 | 32 | 8 | 19 | 6.09 | .352 | 1.62 | 10.8 | 3.8 | 8.9 | 193.2 | 231 | 138 | 131 | 33 | 82 | 191 | 0 | 0 | 0 | 0 | 13 | 3 | 4 | 4.56 |
| SP | Tudor, J.Tudor, John # >> | 31 | 1985 | L | 72 | 31 | 31 | 17 | 8 | 4.15 | .297 | 1.24 | 9.1 | 2.1 | 6.2 | 227.2 | 230 | 107 | 105 | 31 | 53 | 156 | 11 | 0 | 0 | 3 | 15 | 6 | 4 | 4.18 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 98 | 96 | 0 | 4 | 2 | 3.19 | .290 | 1.21 | 7.8 | 3.0 | 9.6 | 62.0 | 54 | 26 | 22 | 5 | 21 | 66 | 0 | 5 | 2 | 0 | 0 | 1 | 1 | 2.98 |
| RP | Betances, D.Betances, Dellin >> | 26 | 2014 | R | 92 | 93 | 0 | 2 | 1 | 1.52 | .233 | 0.91 | 5.5 | 2.7 | 11.8 | 77.0 | 47 | 15 | 13 | 6 | 23 | 101 | 0 | 5 | 2 | 0 | 0 | 0 | 0 | 2.29 |
| RP | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 83 | 64 | 0 | 5 | 1 | 3.61 | .268 | 1.10 | 6.9 | 3.1 | 8.4 | 47.1 | 36 | 19 | 19 | 6 | 16 | 44 | 0 | 4 | 2 | 0 | 0 | 0 | 0 | 3.81 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 84 | 36 | 0 | 3 | 4 | 2.15 | .285 | 1.19 | 7.4 | 3.4 | 9.9 | 29.1 | 24 | 10 | 7 | 4 | 11 | 32 | 0 | 9 | 3 | 0 | 0 | 0 | 0 | 3.72 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 74 | 23 | 0 | 3 | 0 | 3.00 | .337 | 1.52 | 10.3 | 3.4 | 12.9 | 21.0 | 24 | 7 | 7 | 1 | 8 | 30 | 0 | 4 | 0 | 0 | 0 | 0 | 0 | 1.90 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 70 | 30 | 0 | 0 | 0 | 3.21 | .268 | 1.01 | 6.8 | 2.5 | 9.3 | 33.2 | 25 | 12 | 12 | 7 | 9 | 34 | 0 | 1 | 0 | 0 | 0 | 3 | 0 | 4.79 |