| SP | Kershaw, C.Kershaw, Clayton † >> | 28 | 2016 | L | 98 | 37 | 36 | 20 | 7 | 2.77 | .249 | 0.96 | 7.0 | 1.7 | 8.9 | 289.1 | 226 | 95 | 89 | 37 | 53 | 285 | 10 | 0 | 0 | 5 | 27 | 9 | 6 | 3.34 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 92 | 33 | 32 | 12 | 15 | 4.20 | .298 | 1.25 | 8.4 | 2.9 | 8.3 | 212.1 | 197 | 113 | 99 | 36 | 69 | 195 | 2 | 0 | 0 | 0 | 18 | 4 | 6 | 4.40 |
| SP | Flaherty, J.Flaherty, Jack >> | 23 | 2019 | R | 83 | 29 | 27 | 12 | 9 | 3.47 | .274 | 1.11 | 8.1 | 2.0 | 9.0 | 186.2 | 167 | 80 | 72 | 24 | 41 | 186 | 1 | 0 | 0 | 0 | 17 | 3 | 7 | 3.39 |
| RP | Benoit, J.Benoit, Joaquin >> | 33 | 2010 | R | 96 | 79 | 0 | 5 | 3 | 2.66 | .226 | 0.88 | 5.1 | 2.8 | 8.7 | 105.0 | 59 | 31 | 31 | 7 | 33 | 102 | 0 | 3 | 3 | 0 | 0 | 0 | 1 | 2.87 |
| RP | Street, H.Street, Huston † >> | 29 | 2012 | R | 95 | 80 | 0 | 5 | 1 | 2.01 | .247 | 0.95 | 5.2 | 3.4 | 8.0 | 89.1 | 51 | 22 | 20 | 10 | 34 | 79 | 0 | 12 | 2 | 0 | 0 | 3 | 0 | 3.93 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 89 | 59 | 0 | 1 | 7 | 3.03 | .271 | 1.09 | 6.5 | 3.3 | 8.0 | 65.1 | 47 | 22 | 22 | 8 | 24 | 58 | 0 | 7 | 2 | 0 | 0 | 2 | 0 | 4.02 |
| RP | Doolittle, S.Doolittle, Sean >> | 27 | 2014 | L | 85 | 90 | 0 | 2 | 2 | 3.02 | .217 | 0.83 | 5.8 | 1.7 | 10.2 | 62.2 | 40 | 22 | 21 | 6 | 12 | 70 | 0 | 11 | 3 | 0 | 0 | 0 | 0 | 2.58 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 74 | 29 | 0 | 3 | 3 | 2.61 | .295 | 1.23 | 6.6 | 4.6 | 9.4 | 41.1 | 30 | 13 | 12 | 6 | 21 | 43 | 0 | 2 | 0 | 0 | 0 | 1 | 3 | 4.41 |