| SP | Williams, J.Williams, Jerome $$ >> | 27 | 2003 | R | 87 | 24 | 24 | 10 | 8 | 4.41 | .309 | 1.28 | 9.3 | 2.2 | 5.4 | 153.0 | 158 | 82 | 75 | 27 | 38 | 91 | 5 | 0 | 0 | 2 | 13 | 9 | 2 | 5.03 |
| SP | James, C.James, Chuck $$ >> | 27 | 2006 | L | 78 | 24 | 24 | 6 | 13 | 5.72 | .333 | 1.48 | 8.8 | 4.5 | 6.8 | 118.0 | 116 | 78 | 75 | 20 | 59 | 89 | 0 | 0 | 0 | 0 | 5 | 2 | 2 | 5.25 |
| SP | Bonderman, J.Bonderman, Jeremy $$ >> | 26 | 2004 | R | 70 | 23 | 22 | 10 | 4 | 3.93 | .282 | 1.18 | 7.6 | 3.1 | 7.1 | 132.2 | 111 | 63 | 58 | 21 | 45 | 104 | 0 | 1 | 0 | 0 | 15 | 0 | 3 | 4.52 |
| SP | Bedard, E.Bedard, Erik $$ >> | 29 | 2007 | L | 79 | 21 | 21 | 9 | 8 | 6.02 | .350 | 1.60 | 11.9 | 2.5 | 9.2 | 107.2 | 142 | 74 | 72 | 23 | 30 | 109 | 0 | 0 | 0 | 0 | 8 | 2 | 1 | 4.65 |
| SP | Vargas, C.Vargas, Claudio # $ >> | 30 | 2003 | R | 69 | 18 | 18 | 5 | 8 | 6.48 | .349 | 1.56 | 10.5 | 3.6 | 5.4 | 90.1 | 105 | 65 | 65 | 19 | 36 | 54 | 1 | 0 | 0 | 1 | 6 | 4 | 4 | 5.88 |
| RP | Delcarmen, M.Delcarmen, Manny $$ >> | 26 | 2007 | R | 86 | 70 | 0 | 5 | 2 | 4.34 | .314 | 1.30 | 7.7 | 4.0 | 6.3 | 56.0 | 48 | 27 | 27 | 10 | 25 | 39 | 0 | 3 | 5 | 0 | 0 | 4 | 0 | 5.48 |
| RP | Timm, J.Timm, Jordan # $$ >> | 26 | 2026 | R | 81 | 49 | 0 | 0 | 2 | 5.49 | .306 | 1.33 | 8.8 | 3.2 | 10.7 | 57.1 | 56 | 35 | 35 | 9 | 20 | 68 | 0 | 6 | 2 | 0 | 0 | 0 | 0 | 3.72 |
| RP | Capps, M.Capps, Matt $$ >> | 25 | 2007 | R | 77 | 32 | 0 | 3 | 3 | 5.50 | .318 | 1.40 | 8.5 | 4.2 | 7.9 | 34.1 | 32 | 21 | 21 | 5 | 16 | 30 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 4.56 |
| CL | Papelbon, J.Papelbon, Jonathan $$ >> | 28 | 2006 | R | 99 | 45 | 0 | 2 | 3 | 3.07 | .265 | 1.08 | 6.9 | 2.8 | 9.8 | 70.1 | 54 | 25 | 24 | 10 | 22 | 76 | 0 | 19 | 4 | 0 | 0 | 0 | 7 | 3.63 |
| RP | Balfour, G.Balfour, Grant $$ >> | 31 | 2008 | R | 94 | 32 | 0 | 2 | 1 | 2.36 | .259 | 1.02 | 4.8 | 4.5 | 11.1 | 34.1 | 18 | 9 | 9 | 3 | 17 | 42 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 3.26 |