| SP | Paige, S.Paige, Satchel # >> | 28 | 1934 | R | 84 | 31 | 31 | 14 | 12 | 4.78 | .322 | 1.40 | 9.5 | 3.1 | 7.5 | 239.0 | 251 | 135 | 127 | 33 | 83 | 200 | 11 | 0 | 0 | 0 | 14 | 6 | 0 | 4.24 |
| SP | Leonard, D.Leonard, Dutch † $ >> | 22 | 1914 | L | 89 | 30 | 30 | 13 | 11 | 4.31 | .296 | 1.24 | 7.4 | 3.8 | 5.0 | 188.0 | 154 | 92 | 90 | 13 | 79 | 105 | 1 | 0 | 0 | 1 | 16 | 4 | 1 | 4.11 |
| SP | Scherzer, M.Scherzer, Max >> | 33 | 2017 | R | 90 | 30 | 30 | 14 | 7 | 4.66 | .321 | 1.38 | 8.2 | 4.2 | 8.2 | 197.0 | 180 | 103 | 102 | 20 | 91 | 180 | 0 | 0 | 0 | 0 | 15 | 8 | 5 | 4.00 |
| SP | Cicotte, E.Cicotte, Eddie # >> | 33 | 1917 | R | 65 | 26 | 26 | 15 | 9 | 5.66 | .333 | 1.48 | 9.7 | 3.6 | 3.8 | 183.0 | 197 | 119 | 115 | 28 | 74 | 78 | 2 | 0 | 0 | 0 | 12 | 3 | 3 | 5.40 |
| RP | Hendriks, L.Hendriks, Liam >> | 32 | 2021 | R | 84 | 69 | 0 | 3 | 4 | 4.50 | .271 | 1.10 | 7.4 | 2.6 | 8.9 | 88.0 | 72 | 47 | 44 | 12 | 25 | 87 | 0 | 7 | 5 | 0 | 0 | 1 | 5 | 3.68 |
| RP | Papelbon, J.Papelbon, Jon >> | 27 | 2007 | R | 92 | 16 | 0 | 2 | 1 | 5.29 | .292 | 1.12 | 6.9 | 3.2 | 8.5 | 17.0 | 13 | 10 | 10 | 3 | 6 | 16 | 0 | 1 | 1 | 0 | 0 | 2 | 0 | 4.82 |
| RP | Boxberger, B.Boxberger, Brad >> | 26 | 2014 | R | 83 | 17 | 0 | 1 | 1 | 3.86 | .290 | 1.16 | 5.6 | 5.1 | 10.7 | 16.1 | 10 | 7 | 7 | 1 | 9 | 19 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 3.31 |
| RP | Clase, E.Clase, Emmanuel $ >> | 24 | 2022 | R | 82 | 48 | 0 | 4 | 5 | 3.35 | .314 | 1.33 | 9.9 | 2.1 | 7.9 | 51.0 | 56 | 19 | 19 | 0 | 12 | 45 | 0 | 6 | 1 | 0 | 0 | 2 | 3 | 2.06 |
| SP | Sutton, D.Sutton, Don # >> | 27 | 1972 | R | 73 | 25 | 25 | 10 | 13 | 5.41 | .330 | 1.45 | 10.2 | 2.9 | 5.7 | 188.0 | 213 | 113 | 113 | 27 | 60 | 120 | 10 | 0 | 0 | 2 | 7 | 5 | 4 | 4.63 |