| SP | Koufax, S.Koufax, Sandy $ >> | 30 | 1965 | L | 96 | 27 | 27 | 9 | 14 | 3.60 | .301 | 1.26 | 8.0 | 3.4 | 7.8 | 190.0 | 168 | 83 | 76 | 19 | 72 | 165 | 7 | 0 | 0 | 2 | 16 | 5 | 4 | 3.78 |
| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 90 | 26 | 26 | 8 | 15 | 5.07 | .312 | 1.35 | 8.8 | 3.4 | 7.3 | 161.2 | 158 | 92 | 91 | 19 | 61 | 131 | 2 | 0 | 0 | 0 | 12 | 1 | 4 | 4.06 |
| SP | Nelson, R.Nelson, Roger >> | 28 | 1972 | R | 77 | 26 | 26 | 7 | 11 | 6.13 | .340 | 1.53 | 10.7 | 3.1 | 4.8 | 126.1 | 150 | 90 | 86 | 21 | 43 | 67 | 0 | 0 | 0 | 0 | 5 | 2 | 5 | 5.17 |
| RP | Wagner, B.Wagner, Billy † >> | 28 | 1999 | L | 97 | 54 | 0 | 6 | 0 | 2.84 | .282 | 1.12 | 7.0 | 3.1 | 9.4 | 73.0 | 57 | 27 | 23 | 8 | 25 | 76 | 0 | 6 | 1 | 0 | 0 | 4 | 1 | 3.53 |
| RP | Papelbon, J.Papelbon, Jon >> | 27 | 2007 | R | 93 | 45 | 0 | 3 | 2 | 3.11 | .260 | 1.05 | 6.7 | 2.8 | 8.7 | 55.0 | 41 | 19 | 19 | 6 | 17 | 53 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 3.42 |
| RP | Benitez, A.Benitez, Armando >> | 32 | 2004 | R | 80 | 35 | 0 | 0 | 1 | 2.59 | .282 | 1.18 | 6.1 | 4.6 | 6.1 | 41.2 | 28 | 12 | 12 | 2 | 21 | 28 | 0 | 5 | 2 | 0 | 0 | 0 | 0 | 3.80 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 77 | 26 | 0 | 3 | 0 | 2.34 | .278 | 1.13 | 5.6 | 4.8 | 8.7 | 34.2 | 21 | 9 | 9 | 3 | 18 | 33 | 0 | 2 | 0 | 0 | 0 | 1 | 0 | 3.88 |