| SP | Chesbro, J.Chesbro, Jack >> | 30 | 1904 | R | 51 | 31 | 31 | 13 | 11 | 4.47 | .328 | 1.45 | 9.2 | 3.9 | 5.0 | 233.1 | 238 | 126 | 116 | 22 | 101 | 129 | 6 | 0 | 0 | 1 | 13 | 2 | 5 | 4.45 |
| SP | Ryan, N.Ryan, Nolan † $$ >> | 44 | 1991 | R | 66 | 29 | 29 | 14 | 5 | 3.99 | .296 | 1.24 | 6.3 | 4.9 | 8.4 | 185.0 | 130 | 88 | 82 | 26 | 100 | 173 | 1 | 0 | 0 | 0 | 18 | 3 | 8 | 4.63 |
| SP | Cicotte, E.Cicotte, Eddie # >> | 33 | 1917 | R | 65 | 28 | 28 | 12 | 11 | 4.58 | .322 | 1.41 | 10.0 | 2.8 | 4.5 | 194.2 | 215 | 105 | 99 | 18 | 60 | 98 | 5 | 0 | 0 | 3 | 14 | 2 | 6 | 4.15 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 71 | 55 | 0 | 1 | 2 | 2.08 | .263 | 1.07 | 4.4 | 5.4 | 8.3 | 60.2 | 29 | 15 | 14 | 3 | 36 | 55 | 0 | 2 | 1 | 0 | 0 | 0 | 2 | 3.62 |
| RP | Nelson, J.Nelson, Jeff $ >> | 35 | 2001 | R | 45 | 43 | 0 | 6 | 1 | 3.56 | .267 | 1.07 | 5.4 | 4.2 | 7.5 | 43.0 | 26 | 17 | 17 | 6 | 20 | 36 | 0 | 1 | 2 | 0 | 0 | 1 | 0 | 4.60 |
| RP | Marmol, C.Marmol, Carlos >> | 28 | 2010 | R | 40 | 25 | 0 | 2 | 1 | 4.64 | .366 | 1.73 | 6.4 | 9.4 | 9.9 | 21.1 | 15 | 11 | 11 | 2 | 22 | 23 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 5.19 |
| RP | Marte, D.Marte, Damaso >> | 28 | 2003 | L | 30 | 27 | 0 | 0 | 0 | 5.56 | .320 | 1.41 | 7.0 | 6.1 | 8.6 | 22.2 | 17 | 14 | 14 | 4 | 15 | 21 | 0 | 1 | 0 | 0 | 0 | 0 | 2 | 5.50 |
| SP | Hendrix, C.Hendrix, Claude >> | 25 | 1914 | R | 56 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Waddell, R.Waddell, Rube # >> | 29 | 1905 | L | 54 | 24 | 24 | 9 | 12 | 4.90 | .319 | 1.39 | 9.5 | 3.1 | 5.8 | 174.2 | 183 | 100 | 95 | 26 | 59 | 112 | 6 | 0 | 0 | 1 | 9 | 3 | 9 | 4.72 |