| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 27 | 27 | 14 | 7 | 2.94 | .261 | 1.04 | 6.9 | 2.6 | 8.5 | 180.1 | 137 | 63 | 59 | 13 | 51 | 170 | 0 | 0 | 0 | 0 | 21 | 3 | 0 | 2.95 |
| SP | Greinke, Z.Greinke, Zack >> | 32 | 2015 | R | 91 | 26 | 26 | 5 | 15 | 5.99 | .344 | 1.55 | 10.3 | 3.7 | 6.6 | 156.1 | 178 | 108 | 104 | 24 | 64 | 114 | 2 | 0 | 0 | 0 | 11 | 4 | 5 | 4.85 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 76 | 26 | 26 | 8 | 12 | 5.37 | .338 | 1.53 | 9.8 | 3.9 | 8.5 | 139.0 | 151 | 90 | 83 | 21 | 61 | 132 | 0 | 0 | 0 | 0 | 11 | 1 | 5 | 4.40 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 75 | 26 | 26 | 6 | 17 | 5.47 | .324 | 1.42 | 9.8 | 3.0 | 8.3 | 163.0 | 177 | 100 | 99 | 29 | 54 | 151 | 6 | 0 | 0 | 2 | 11 | 3 | 2 | 4.51 |
| RP | Percival, T.Percival, Troy >> | 26 | 1995 | R | 79 | 70 | 0 | 5 | 2 | 3.53 | .314 | 1.35 | 7.7 | 4.6 | 9.1 | 81.2 | 69 | 34 | 32 | 9 | 41 | 82 | 0 | 1 | 0 | 0 | 0 | 2 | 1 | 4.01 |
| RP | Clippard, T.Clippard, Tyler >> | 26 | 2011 | R | 77 | 65 | 0 | 0 | 4 | 3.61 | .267 | 1.06 | 6.9 | 2.7 | 8.8 | 89.2 | 68 | 41 | 36 | 14 | 27 | 87 | 0 | 1 | 2 | 0 | 0 | 3 | 1 | 4.10 |
| RP | Wilhelm, H.Wilhelm, Hoyt >> | 43 | 1965 | R | 65 | 47 | 0 | 1 | 4 | 5.35 | .322 | 1.41 | 8.8 | 4.1 | 5.5 | 75.2 | 73 | 55 | 45 | 12 | 34 | 46 | 0 | 1 | 2 | 0 | 0 | 1 | 3 | 5.25 |
| CL | Jansen, K.Jansen, Kenley >> | 28 | 2016 | R | 99 | 56 | 0 | 1 | 10 | 4.78 | .307 | 1.33 | 9.3 | 2.8 | 8.5 | 52.2 | 54 | 29 | 28 | 8 | 16 | 49 | 0 | 24 | 3 | 0 | 0 | 0 | 0 | 4.04 |
| RP | Harvey, B.Harvey, Bryan >> | 28 | 1991 | R | 61 | 39 | 0 | 0 | 0 | 3.25 | .281 | 1.17 | 8.0 | 2.7 | 7.6 | 44.1 | 39 | 16 | 16 | 4 | 13 | 37 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 3.39 |