| SP | deGrom, J.deGrom, Jacob † $ >> | 33 | 2021 | R | 100 | 27 | 27 | 10 | 11 | 3.21 | .262 | 1.03 | 7.3 | 2.0 | 9.6 | 182.1 | 148 | 66 | 65 | 22 | 40 | 194 | 3 | 0 | 0 | 1 | 18 | 6 | 0 | 3.20 |
| SP | Greinke, Z.Greinke, Zack # >> | 32 | 2015 | R | 91 | 27 | 27 | 10 | 11 | 4.81 | .318 | 1.39 | 9.4 | 3.1 | 5.0 | 181.2 | 190 | 103 | 97 | 29 | 63 | 101 | 2 | 0 | 0 | 0 | 13 | 1 | 4 | 5.03 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 76 | 26 | 26 | 6 | 7 | 6.31 | .339 | 1.51 | 9.9 | 3.7 | 7.0 | 134.0 | 148 | 97 | 94 | 26 | 55 | 104 | 0 | 0 | 0 | 0 | 10 | 3 | 3 | 5.27 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 75 | 26 | 26 | 10 | 11 | 4.40 | .302 | 1.28 | 8.5 | 3.0 | 8.4 | 180.0 | 170 | 88 | 88 | 20 | 60 | 168 | 4 | 0 | 0 | 1 | 13 | 4 | 2 | 3.64 |
| RP | Jansen, K.Jansen, Kenley $ >> | 28 | 2016 | R | 99 | 81 | 0 | 6 | 4 | 2.20 | .235 | 0.91 | 6.0 | 2.2 | 9.4 | 90.0 | 60 | 22 | 22 | 8 | 22 | 94 | 0 | 5 | 5 | 0 | 0 | 1 | 1 | 2.83 |
| RP | Percival, T.Percival, Troy >> | 26 | 1995 | R | 79 | 52 | 0 | 4 | 1 | 4.26 | .316 | 1.39 | 8.4 | 4.1 | 7.9 | 57.0 | 53 | 28 | 27 | 7 | 26 | 50 | 0 | 4 | 3 | 0 | 0 | 0 | 2 | 4.21 |
| RP | Gallegos, G.Gallegos, Giovanny >> | 27 | 2019 | R | 78 | 44 | 0 | 7 | 3 | 3.76 | .263 | 1.07 | 7.4 | 2.3 | 9.3 | 55.0 | 45 | 23 | 23 | 12 | 14 | 57 | 0 | 3 | 3 | 0 | 0 | 0 | 0 | 4.53 |
| RP | Rhodes, A.Rhodes, Arthur >> | 32 | 2001 | L | 59 | 85 | 0 | 2 | 4 | 4.52 | .260 | 1.04 | 7.3 | 2.1 | 8.1 | 63.2 | 51 | 34 | 32 | 10 | 15 | 57 | 0 | 4 | 2 | 0 | 0 | 1 | 2 | 4.02 |
| SP | Bender, C.Bender, Chief >> | 26 | 1910 | R | 62 | 28 | 0 | 2 | 2 | 2.50 | .274 | 1.11 | 7.5 | 2.5 | 5.3 | 54.0 | 45 | 16 | 15 | 6 | 15 | 32 | 0 | 7 | 0 | 0 | 0 | 1 | 0 | 4.15 |