| SP | deGrom, J.deGrom, Jacob $ >> | 33 | 2021 | R | 100 | 6 | 6 | 2 | 2 | 2.86 | .237 | 0.93 | 6.8 | 1.6 | 8.8 | 44.0 | 33 | 14 | 14 | 5 | 8 | 43 | 1 | 0 | 0 | 0 | 4 | 0 | 0 | 3.07 |
| SP | Greinke, Z.Greinke, Zack >> | 32 | 2015 | R | 90 | 6 | 6 | 3 | 3 | 4.35 | .295 | 1.26 | 8.8 | 2.6 | 6.1 | 41.1 | 40 | 20 | 20 | 9 | 12 | 28 | 2 | 0 | 0 | 0 | 4 | 0 | 1 | 5.37 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 76 | 5 | 5 | 2 | 2 | 6.08 | .328 | 1.46 | 9.3 | 4.2 | 8.3 | 26.2 | 27 | 18 | 18 | 3 | 12 | 24 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 4.04 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 75 | 5 | 5 | 2 | 3 | 6.67 | .360 | 1.65 | 9.9 | 5.3 | 9.0 | 29.2 | 32 | 22 | 22 | 3 | 17 | 29 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 4.21 |
| RP | Jansen, K.Jansen, Kenley $ >> | 28 | 2016 | R | 99 | 13 | 0 | 0 | 1 | 1.50 | .239 | 0.89 | 4.5 | 3.5 | 10.0 | 18.0 | 9 | 3 | 3 | 0 | 7 | 20 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 2.11 |
| RP | Percival, T.Percival, Troy >> | 26 | 1995 | R | 79 | 9 | 0 | 0 | 0 | 8.64 | .419 | 2.16 | 10.1 | 10.1 | 7.9 | 8.1 | 9 | 8 | 8 | 1 | 9 | 7 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 6.25 |
| RP | Gallegos, G.Gallegos, Giovanny >> | 27 | 2019 | R | 78 | 9 | 0 | 2 | 0 | 5.23 | .340 | 1.55 | 10.8 | 3.6 | 9.9 | 10.1 | 12 | 6 | 6 | 2 | 4 | 11 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 4.60 |
| RP | Rhodes, A.Rhodes, Arthur >> | 32 | 2001 | L | 59 | 16 | 0 | 0 | 1 | 4.70 | .246 | 0.98 | 7.8 | 1.2 | 9.6 | 15.1 | 13 | 8 | 8 | 4 | 2 | 16 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 4.73 |
| SP | Bender, C.Bender, Chief >> | 26 | 1910 | R | 62 | 5 | 0 | 0 | 0 | 7.56 | .375 | 1.80 | 14.6 | 2.3 | 5.6 | 8.1 | 13 | 7 | 7 | 3 | 2 | 5 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 7.38 |