| SP | McNally, D.McNally, Dave >> | 26 | 1968 | L | 95 | 33 | 33 | 17 | 6 | 3.66 | .294 | 1.23 | 8.2 | 2.8 | 4.9 | 245.2 | 224 | 107 | 100 | 20 | 77 | 134 | 6 | 0 | 0 | 1 | 20 | 6 | 5 | 3.98 |
| SP | Snell, B.Snell, Blake # $ >> | 25 | 2018 | L | 74 | 32 | 32 | 15 | 7 | 4.42 | .306 | 1.31 | 8.0 | 3.8 | 8.3 | 197.1 | 175 | 103 | 97 | 21 | 84 | 181 | 0 | 0 | 0 | 0 | 14 | 2 | 4 | 3.86 |
| SP | Hendrix, C.Hendrix, Claude >> | 25 | 1914 | R | 56 | 29 | 29 | 15 | 9 | 4.34 | .318 | 1.38 | 8.8 | 3.6 | 4.1 | 203.1 | 198 | 104 | 98 | 20 | 82 | 92 | 4 | 0 | 0 | 0 | 15 | 5 | 9 | 4.66 |
| SP | Waddell, R.Waddell, Rube >> | 29 | 1905 | L | 54 | 26 | 24 | 10 | 9 | 4.35 | .329 | 1.45 | 9.6 | 3.4 | 5.4 | 182.0 | 194 | 94 | 88 | 25 | 69 | 109 | 1 | 1 | 0 | 0 | 11 | 5 | 1 | 4.81 |
| RP | Wagner, B.Wagner, Billy >> | 28 | 1999 | L | 97 | 95 | 0 | 2 | 2 | 2.75 | .286 | 1.18 | 5.4 | 5.4 | 9.3 | 52.1 | 31 | 16 | 16 | 3 | 31 | 54 | 0 | 11 | 3 | 0 | 0 | 1 | 2 | 3.52 |
| RP | Holland, G.Holland, Greg >> | 27 | 2013 | R | 68 | 66 | 0 | 3 | 1 | 1.32 | .214 | 0.82 | 4.6 | 2.9 | 9.4 | 47.2 | 24 | 9 | 7 | 4 | 15 | 49 | 0 | 8 | 3 | 0 | 0 | 0 | 2 | 2.98 |
| RP | Clippard, T.Clippard, Tyler >> | 26 | 2011 | R | 76 | 61 | 0 | 4 | 2 | 3.43 | .293 | 1.19 | 7.2 | 3.7 | 6.7 | 39.1 | 31 | 15 | 15 | 3 | 16 | 29 | 0 | 4 | 4 | 0 | 0 | 2 | 1 | 3.90 |
| RP | Davis, W.Davis, Wade # >> | 29 | 2015 | R | 88 | 70 | 0 | 4 | 3 | 5.01 | .330 | 1.46 | 9.0 | 4.3 | 8.6 | 46.2 | 46 | 28 | 26 | 8 | 22 | 44 | 0 | 2 | 1 | 0 | 0 | 1 | 1 | 4.85 |
| RP | Zimmerman, J.Zimmerman, Jeff >> | 27 | 1999 | R | 67 | 18 | 0 | 0 | 2 | 4.26 | .250 | 1.00 | 6.6 | 2.4 | 6.6 | 19.0 | 14 | 9 | 9 | 3 | 5 | 14 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 4.37 |
| RP | Foulke, K.Foulke, Keith >> | 27 | 1999 | R | 52 | 6 | 0 | 1 | 2 | 17.18 | .522 | 3.00 | 27.0 | 6.0 | 12.0 | 3.2 | 9 | 7 | 7 | 3 | 2 | 4 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 16.33 |
| RP | Hernandez, W.Hernandez, Willie >> | 30 | 1984 | L | 36 | 57 | 0 | 1 | 4 | 3.29 | .285 | 1.20 | 8.3 | 2.4 | 5.7 | 41.0 | 38 | 17 | 15 | 5 | 11 | 26 | 0 | 6 | 2 | 0 | 0 | 0 | 2 | 4.12 |
| RP | Martinez, T.Martinez, Tippy >> | 33 | 1983 | L | 4 | 15 | 0 | 0 | 0 | 4.32 | .342 | 1.56 | 12.4 | 2.3 | 3.4 | 8.1 | 11 | 4 | 4 | 1 | 2 | 3 | 0 | 1 | 2 | 0 | 0 | 0 | 1 | 4.63 |