| SP | Scherzer, M.Scherzer, Max † | Orioles | R | 142.0 | 34 | 34 | 18 | 13 | 3.07 | .286 | 1.16 | 8.2 | 2.2 | 10.2 | 246.0 | 225 | 87 | 84 | 22 | 61 | 278 | 2 | 0 | 0 | 1 | 25 | 10 | 2 | 2.77 |
| SP | Cotton, J.Cotton, Jharel † | Athletics | R | 132.0 | 33 | 33 | 14 | 9 | 2.50 | .273 | 1.10 | 7.9 | 2.0 | 7.9 | 220.0 | 193 | 68 | 61 | 16 | 50 | 192 | 2 | 0 | 0 | 1 | 27 | 5 | 7 | 2.95 |
| CL | Britton, Z.Britton, Zach † | Orioles | L | 130.5 | 55 | 0 | 2 | 2 | 3.23 | .293 | 1.23 | 8.0 | 3.1 | 12.2 | 53.0 | 47 | 19 | 19 | 1 | 18 | 72 | 0 | 45 | 4 | 0 | 0 | 1 | 3 | 1.60 |
| SP | Porcello, R.Porcello, Rick # | Twins | R | 125.0 | 31 | 31 | 17 | 8 | 3.48 | .294 | 1.23 | 8.8 | 2.3 | 8.0 | 227.2 | 223 | 92 | 88 | 12 | 57 | 201 | 2 | 0 | 0 | 0 | 19 | 5 | 2 | 2.74 |
| SP | Guerra, J.Guerra, Junior † | Brewers | R | 123.0 | 36 | 36 | 17 | 10 | 3.36 | .300 | 1.27 | 7.5 | 4.0 | 8.1 | 230.2 | 191 | 88 | 86 | 12 | 101 | 207 | 0 | 0 | 0 | 0 | 25 | 4 | 4 | 3.25 |
| SP | Fernandez, J.Fernandez, Jose † | Twins | R | 117.0 | 33 | 33 | 16 | 12 | 3.69 | .305 | 1.27 | 8.3 | 3.1 | 10.6 | 229.0 | 210 | 94 | 94 | 21 | 80 | 270 | 4 | 0 | 0 | 2 | 23 | 12 | 12 | 3.04 |