| SP | Sabathia, C.Sabathia, CC † # $ | Cubs | L | 158.0 | 33 | 33 | 20 | 4 | 3.62 | .286 | 1.18 | 8.5 | 2.2 | 7.7 | 226.1 | 213 | 100 | 91 | 28 | 55 | 194 | 14 | 0 | 0 | 2 | 20 | 4 | 2 | 3.68 |
| SP | Perez, C.Perez, Chris # $$ | Phillies | R | 144.0 | 31 | 31 | 18 | 5 | 3.31 | .275 | 1.12 | 7.6 | 2.6 | 7.1 | 222.2 | 187 | 89 | 82 | 28 | 63 | 174 | 7 | 0 | 0 | 2 | 19 | 4 | 6 | 3.98 |
| SP | Youman, S.Youman, Shane † $$ | Phillies | L | 135.0 | 33 | 33 | 17 | 8 | 3.07 | .262 | 1.07 | 7.5 | 2.1 | 6.8 | 223.0 | 186 | 85 | 76 | 23 | 52 | 168 | 4 | 0 | 0 | 1 | 25 | 0 | 6 | 3.53 |
| SP | Prieto, A.Prieto, Ariel $$ | Pirates | R | 133.0 | 31 | 31 | 18 | 7 | 3.67 | .286 | 1.18 | 8.6 | 2.0 | 7.8 | 218.1 | 209 | 98 | 89 | 24 | 49 | 188 | 7 | 0 | 0 | 3 | 19 | 5 | 5 | 3.45 |
| SP | Vogelsong, R.Vogelsong, Ryan † $$ | Pirates | R | 124.0 | 31 | 31 | 15 | 9 | 3.48 | .279 | 1.12 | 8.0 | 2.1 | 7.8 | 225.0 | 201 | 91 | 87 | 29 | 52 | 194 | 11 | 0 | 0 | 2 | 15 | 8 | 0 | 3.75 |
| SP | Jurrjens, J.Jurrjens, Jair $$ | Pirates | R | 121.0 | 30 | 30 | 16 | 9 | 3.29 | .289 | 1.21 | 7.9 | 3.0 | 6.7 | 205.0 | 179 | 78 | 75 | 10 | 69 | 153 | 6 | 0 | 0 | 3 | 20 | 2 | 2 | 3.18 |
| SP | Halladay, R.Halladay, Roy $$ | Rockies | R | 121.0 | 32 | 32 | 16 | 10 | 3.22 | .266 | 1.05 | 6.8 | 2.7 | 7.7 | 220.2 | 165 | 84 | 79 | 26 | 67 | 189 | 3 | 0 | 0 | 0 | 24 | 8 | 2 | 3.84 |
| RP | Fruto, E.Fruto, Emiliano † $$ | Pirates | R | 114.5 | 72 | 0 | 9 | 4 | 2.89 | .289 | 1.19 | 6.9 | 3.8 | 9.5 | 118.1 | 91 | 42 | 38 | 13 | 50 | 124 | 0 | 17 | 2 | 0 | 0 | 3 | 6 | 3.68 |
| SP | Howell, J.Howell, J.P. $$ | Dodgers | L | 114.0 | 29 | 29 | 15 | 7 | 3.64 | .278 | 1.15 | 8.6 | 1.8 | 6.2 | 220.0 | 210 | 93 | 89 | 22 | 44 | 152 | 6 | 0 | 0 | 2 | 16 | 0 | 1 | 3.52 |
| SP | Verlander, J.Verlander, Justin † # $$ | Mets | R | 114.0 | 32 | 32 | 14 | 12 | 3.16 | .273 | 1.10 | 7.7 | 2.2 | 6.8 | 236.2 | 203 | 86 | 83 | 25 | 58 | 177 | 5 | 0 | 0 | 1 | 22 | 5 | 1 | 3.68 |