| SP | Peavy, J.Peavy, Jake † # $ | Mariners | R | 117.0 | 28 | 28 | 16 | 3 | 3.81 | .277 | 1.14 | 8.3 | 2.0 | 7.0 | 193.2 | 178 | 83 | 82 | 24 | 43 | 150 | 4 | 0 | 0 | 2 | 16 | 2 | 3 | 3.76 |
| CL | Feldman, S.Feldman, Scott † $$ | White Sox | R | 111.0 | 56 | 0 | 7 | 5 | 2.75 | .265 | 1.07 | 7.0 | 2.6 | 10.6 | 72.0 | 56 | 23 | 22 | 9 | 21 | 85 | 0 | 26 | 4 | 0 | 0 | 1 | 0 | 3.18 |
| SP | Leake, M.Leake, Mike † $$ | Rangers | R | 110.0 | 27 | 27 | 16 | 10 | 3.39 | .281 | 1.15 | 8.4 | 2.0 | 6.7 | 194.0 | 181 | 81 | 73 | 24 | 43 | 145 | 3 | 0 | 0 | 1 | 17 | 4 | 1 | 3.84 |
| SP | Claussen, B.Claussen, Brandon † $$ | Blue Jays | L | 97.0 | 27 | 27 | 16 | 7 | 3.94 | .296 | 1.24 | 9.2 | 2.0 | 7.0 | 166.2 | 170 | 79 | 73 | 20 | 36 | 130 | 1 | 0 | 0 | 1 | 18 | 4 | 3 | 3.72 |
| SP | Burres, B.Burres, Brian † $$ | Tigers | L | 93.0 | 25 | 25 | 13 | 5 | 3.78 | .285 | 1.19 | 8.7 | 1.9 | 7.5 | 176.0 | 171 | 76 | 74 | 23 | 38 | 147 | 2 | 0 | 0 | 1 | 17 | 1 | 6 | 3.69 |
| CL | Marmol, C.Marmol, Carlos † $$ | Blue Jays | R | 92.5 | 55 | 0 | 5 | 5 | 3.88 | .337 | 1.51 | 7.5 | 6.2 | 7.4 | 60.1 | 50 | 26 | 26 | 8 | 41 | 49 | 0 | 27 | 1 | 0 | 0 | 1 | 2 | 5.20 |
| SP | Stults, E.Stults, Eric # $$ | Tigers | L | 90.0 | 27 | 27 | 14 | 9 | 4.08 | .267 | 1.08 | 8.0 | 1.8 | 7.3 | 196.1 | 174 | 92 | 89 | 24 | 39 | 160 | 6 | 0 | 0 | 0 | 14 | 2 | 2 | 3.59 |
| CL | O'Day, D.O'Day, Darren † $$ | Orioles | R | 90.0 | 51 | 0 | 4 | 4 | 2.50 | .261 | 1.02 | 5.5 | 3.8 | 7.1 | 57.2 | 35 | 19 | 16 | 2 | 24 | 45 | 0 | 26 | 5 | 0 | 0 | 2 | 0 | 3.25 |
| SP | Medlen, K.Medlen, Kris # $$ | Yankees | R | 87.0 | 28 | 28 | 15 | 8 | 4.13 | .304 | 1.28 | 8.8 | 2.7 | 7.4 | 161.1 | 158 | 89 | 74 | 28 | 49 | 133 | 1 | 0 | 0 | 1 | 17 | 4 | 0 | 4.60 |