| SP | Sabathia, C.Sabathia, CC † # $ | Cubs | L | 126.0 | 22 | 22 | 15 | 3 | 3.07 | .268 | 1.08 | 7.9 | 1.8 | 7.8 | 161.1 | 141 | 60 | 55 | 16 | 33 | 139 | 11 | 0 | 0 | 1 | 16 | 3 | 2 | 3.24 |
| SP | Youman, S.Youman, Shane † $$ | Phillies | L | 111.0 | 22 | 22 | 13 | 3 | 2.72 | .257 | 1.04 | 7.4 | 2.0 | 6.8 | 152.1 | 125 | 55 | 46 | 14 | 33 | 114 | 4 | 0 | 0 | 1 | 16 | 0 | 5 | 3.35 |
| SP | Vogelsong, R.Vogelsong, Ryan † $$ | Pirates | R | 100.0 | 20 | 20 | 10 | 5 | 2.77 | .246 | 0.94 | 6.3 | 2.2 | 7.2 | 159.0 | 112 | 52 | 49 | 20 | 38 | 128 | 9 | 0 | 0 | 2 | 12 | 6 | 0 | 3.86 |
| SP | Howell, J.Howell, J.P. $$ | Dodgers | L | 93.0 | 19 | 19 | 10 | 4 | 2.83 | .264 | 1.07 | 8.5 | 1.2 | 6.3 | 152.2 | 144 | 52 | 48 | 11 | 20 | 107 | 5 | 0 | 0 | 2 | 12 | 0 | 0 | 2.93 |
| SP | Verlander, J.Verlander, Justin † # $$ | Mets | R | 89.0 | 21 | 21 | 11 | 7 | 3.00 | .259 | 1.03 | 7.6 | 1.7 | 7.2 | 156.0 | 131 | 54 | 52 | 15 | 30 | 125 | 3 | 0 | 0 | 1 | 15 | 3 | 1 | 3.28 |
| SP | Prieto, A.Prieto, Ariel $$ | Pirates | R | 85.0 | 20 | 20 | 12 | 5 | 3.82 | .284 | 1.16 | 8.4 | 2.1 | 7.3 | 136.2 | 127 | 65 | 58 | 13 | 31 | 111 | 6 | 0 | 0 | 3 | 11 | 5 | 5 | 3.40 |
| CL | Tazawa, J.Tazawa, Junichi † $$ | Cardinals | R | 85.0 | 37 | 0 | 2 | 1 | 1.38 | .213 | 0.79 | 5.2 | 2.0 | 10.2 | 45.2 | 26 | 7 | 7 | 4 | 10 | 51 | 0 | 22 | 0 | 0 | 0 | 1 | 0 | 2.62 |
| CL | Bastardo, A.Bastardo, Antonio † $$ | Dodgers | L | 82.5 | 41 | 0 | 6 | 5 | 3.11 | .284 | 1.14 | 6.5 | 3.9 | 10.2 | 46.1 | 33 | 16 | 16 | 6 | 20 | 52 | 0 | 21 | 3 | 0 | 0 | 2 | 2 | 3.87 |
| SP | Stammen, C.Stammen, Craig $$ | Marlins | R | 81.0 | 20 | 20 | 9 | 6 | 2.72 | .269 | 1.07 | 7.7 | 1.9 | 7.2 | 142.1 | 122 | 47 | 43 | 14 | 30 | 114 | 3 | 0 | 0 | 1 | 16 | 5 | 4 | 3.42 |
| SP | Halladay, R.Halladay, Roy $$ | Rockies | R | 79.0 | 21 | 21 | 10 | 8 | 3.07 | .245 | 0.93 | 6.2 | 2.2 | 8.3 | 149.2 | 102 | 56 | 51 | 18 | 37 | 137 | 3 | 0 | 0 | 0 | 17 | 7 | 1 | 3.62 |