| SP | Martinez, P.Martinez, Pedro † | Warriors | R | 122.0 | 22 | 22 | 13 | 6 | 2.71 | .263 | 1.04 | 7.1 | 2.3 | 10.2 | 172.2 | 136 | 59 | 52 | 16 | 44 | 195 | 8 | 0 | 0 | 2 | 17 | 5 | 4 | 2.80 |
| CL | Rivera, M.Rivera, Mariano † $ | 2000 | R | 94.5 | 48 | 0 | 2 | 3 | 3.06 | .234 | 0.91 | 6.5 | 1.7 | 8.6 | 47.0 | 34 | 18 | 16 | 5 | 9 | 45 | 0 | 33 | 5 | 0 | 0 | 0 | 1 | 3.04 |
| CL | Papelbon, J.Papelbon, Jonathan † | Lady Gagas | R | 86.5 | 44 | 0 | 1 | 1 | 1.60 | .262 | 1.07 | 6.3 | 3.4 | 9.2 | 50.2 | 35 | 10 | 9 | 3 | 19 | 51 | 0 | 25 | 1 | 0 | 0 | 0 | 1 | 2.88 |
| SP | Buehrle, M.Buehrle, Mark † | 2000 | L | 86.0 | 21 | 21 | 13 | 3 | 3.71 | .303 | 1.29 | 8.4 | 3.3 | 6.8 | 135.2 | 126 | 56 | 56 | 21 | 49 | 102 | 0 | 0 | 0 | 0 | 12 | 2 | 0 | 4.64 |
| SP | Clemens, R.Clemens, Roger † | Hornets | R | 86.0 | 22 | 22 | 12 | 4 | 3.41 | .314 | 1.34 | 7.9 | 4.2 | 7.1 | 145.1 | 128 | 59 | 55 | 13 | 67 | 115 | 0 | 0 | 0 | 0 | 14 | 5 | 2 | 4.07 |
| SP | Halladay, R.Halladay, Roy # $ | 2000 | R | 84.0 | 21 | 21 | 9 | 5 | 3.04 | .272 | 1.09 | 7.5 | 2.4 | 6.6 | 156.2 | 130 | 59 | 53 | 16 | 41 | 114 | 6 | 0 | 0 | 1 | 15 | 5 | 0 | 3.76 |
| CL | Soriano, R.Soriano, Rafael † | Hornets | R | 71.0 | 50 | 0 | 2 | 6 | 4.39 | .295 | 1.26 | 8.3 | 3.1 | 9.7 | 53.1 | 49 | 27 | 26 | 6 | 18 | 57 | 0 | 28 | 4 | 0 | 0 | 0 | 0 | 3.34 |