| SP | Kershaw, C.Kershaw, Clayton + | 24 | Grays | L | 91 | 34 | 34 | 16 | 8 | 3.20 | .237 | 0.91 | 6.6 | 1.7 | 7.9 | 255.2 | 186 | 99 | 91 | 29 | 47 | 224 | 13 | 0 | 0 | 6 | 22 | 5 | 4 | 3.33 |
| SP | Martinez, P.Martinez, Pedro | 30 | Royals | R | 100 | 25 | 24 | 13 | 7 | 3.98 | .246 | 0.96 | 7.4 | 1.2 | 7.7 | 167.1 | 137 | 75 | 74 | 32 | 23 | 142 | 10 | 0 | 0 | 0 | 14 | 4 | 1 | 4.28 |
| SP | Johnson, R.Johnson, Randy | 31 | Browns | L | 93 | 35 | 35 | 19 | 11 | 3.26 | .245 | 0.97 | 7.3 | 1.4 | 8.3 | 237.2 | 192 | 94 | 86 | 32 | 38 | 219 | 13 | 0 | 0 | 2 | 28 | 1 | 5 | 3.40 |
| RP | Papelbon, J.Papelbon, Jonathan | 29 | Royals | R | 95 | 60 | 0 | 10 | 2 | 2.74 | .254 | 1.01 | 6.8 | 2.4 | 7.9 | 111.2 | 84 | 37 | 34 | 13 | 29 | 98 | 0 | 3 | 1 | 0 | 0 | 1 | 3 | 3.57 |
| CL | Kimbrel, C.Kimbrel, Craig + | 33 | Browns | R | 93 | 69 | 0 | 5 | 3 | 2.07 | .207 | 0.76 | 4.6 | 2.3 | 9.2 | 121.2 | 62 | 31 | 28 | 11 | 31 | 124 | 0 | 49 | 5 | 0 | 0 | 2 | 1 | 2.95 |
| CL | Chapman, A.Chapman, Aroldis | 32 | Grays | L | 97 | 51 | 0 | 8 | 7 | 2.94 | .241 | 0.94 | 6.2 | 2.3 | 8.1 | 70.1 | 48 | 23 | 23 | 4 | 18 | 63 | 0 | 29 | 6 | 0 | 0 | 1 | 1 | 2.76 |