| SP | Kershaw, C.Kershaw, Clayton + | 24 | Grays | L | 91 | 33 | 33 | 16 | 7 | 3.12 | .234 | 0.90 | 6.5 | 1.6 | 8.0 | 248.1 | 179 | 94 | 86 | 27 | 44 | 221 | 13 | 0 | 0 | 6 | 22 | 5 | 4 | 3.23 |
| SP | Martinez, P.Martinez, Pedro | 30 | Royals | R | 100 | 25 | 24 | 13 | 7 | 3.98 | .246 | 0.96 | 7.4 | 1.2 | 7.7 | 167.1 | 137 | 75 | 74 | 32 | 23 | 142 | 10 | 0 | 0 | 0 | 14 | 4 | 1 | 4.28 |
| SP | Johnson, R.Johnson, Randy | 31 | Browns | L | 93 | 33 | 33 | 18 | 10 | 3.19 | .244 | 0.96 | 7.3 | 1.4 | 8.4 | 228.1 | 185 | 89 | 81 | 31 | 35 | 212 | 13 | 0 | 0 | 2 | 27 | 1 | 5 | 3.38 |
| RP | Papelbon, J.Papelbon, Jonathan | 29 | Royals | R | 95 | 60 | 0 | 10 | 2 | 2.74 | .254 | 1.01 | 6.8 | 2.4 | 7.9 | 111.2 | 84 | 37 | 34 | 13 | 29 | 98 | 0 | 3 | 1 | 0 | 0 | 1 | 3 | 3.57 |
| CL | Kimbrel, C.Kimbrel, Craig + | 33 | Browns | R | 93 | 67 | 0 | 5 | 2 | 1.97 | .207 | 0.76 | 4.5 | 2.3 | 9.3 | 119.0 | 60 | 29 | 26 | 10 | 31 | 123 | 0 | 48 | 5 | 0 | 0 | 2 | 1 | 2.86 |
| CL | Chapman, A.Chapman, Aroldis | 32 | Grays | L | 97 | 51 | 0 | 8 | 7 | 2.94 | .241 | 0.94 | 6.2 | 2.3 | 8.1 | 70.1 | 48 | 23 | 23 | 4 | 18 | 63 | 0 | 29 | 6 | 0 | 0 | 1 | 1 | 2.76 |