| SP | Rodriguez, E.Rodriguez, Eduardo | 33 | Reds | L | 78 | 26 | 26 | 15 | 8 | 3.23 | .228 | 0.84 | 6.4 | 1.2 | 7.5 | 206.0 | 146 | 75 | 74 | 30 | 28 | 171 | 8 | 0 | 0 | 0 | 17 | 9 | 3 | 3.77 |
| SP | Flaherty, J.Flaherty, Jack # | 30 | Pirates | R | 99 | 28 | 28 | 13 | 7 | 2.67 | .225 | 0.87 | 6.0 | 1.8 | 10.0 | 185.2 | 123 | 57 | 55 | 20 | 38 | 206 | 7 | 0 | 0 | 3 | 17 | 1 | 6 | 2.81 |
| SP | Javier, C.Javier, Cristian | 30 | Cubs | R | 100 | 28 | 28 | 14 | 7 | 3.32 | .276 | 1.10 | 7.5 | 2.4 | 10.1 | 173.1 | 144 | 66 | 64 | 22 | 46 | 194 | 0 | 0 | 0 | 0 | 20 | 8 | 4 | 3.35 |
| SP | Ohtani SP, S.Ohtani SP, Shohei | 32 | Brewers | R | 86 | 28 | 28 | 11 | 12 | 4.69 | .306 | 1.28 | 8.7 | 2.9 | 9.7 | 161.1 | 155 | 87 | 84 | 29 | 52 | 173 | 0 | 0 | 0 | 0 | 12 | 6 | 11 | 4.27 |
| CL | Chapman, A.Chapman, Aroldis | 38 | Giants | L | 62 | 48 | 0 | 3 | 5 | 2.58 | .288 | 1.19 | 6.4 | 4.4 | 11.8 | 45.1 | 32 | 14 | 13 | 5 | 22 | 59 | 0 | 31 | 2 | 0 | 0 | 1 | 2 | 3.36 |
| CL | Alvarado, J.Alvarado, Jose | 31 | Cubs | L | 89 | 59 | 0 | 8 | 5 | 2.55 | .237 | 0.91 | 5.8 | 2.5 | 9.9 | 95.1 | 61 | 27 | 27 | 3 | 26 | 104 | 0 | 20 | 6 | 0 | 0 | 2 | 1 | 2.11 |