| SP | Rodriguez, E.Rodriguez, Eduardo | 33 | Reds | L | 78 | 22 | 22 | 14 | 5 | 2.73 | .213 | 0.76 | 5.7 | 1.2 | 7.5 | 184.1 | 117 | 57 | 56 | 23 | 24 | 154 | 8 | 0 | 0 | 0 | 16 | 9 | 2 | 3.49 |
| SP | Flaherty, J.Flaherty, Jack # | 30 | Pirates | R | 99 | 23 | 23 | 11 | 5 | 2.68 | .223 | 0.85 | 5.9 | 1.8 | 9.6 | 151.1 | 99 | 46 | 45 | 15 | 30 | 161 | 6 | 0 | 0 | 3 | 14 | 1 | 5 | 2.77 |
| SP | Javier, C.Javier, Cristian | 30 | Cubs | R | 100 | 23 | 23 | 11 | 6 | 3.19 | .279 | 1.11 | 7.6 | 2.4 | 10.6 | 144.0 | 122 | 53 | 51 | 18 | 38 | 169 | 0 | 0 | 0 | 0 | 17 | 7 | 3 | 3.22 |
| SP | Ohtani SP, S.Ohtani SP, Shohei | 32 | Brewers | R | 86 | 23 | 23 | 11 | 7 | 3.84 | .292 | 1.19 | 8.0 | 2.8 | 10.1 | 138.1 | 122 | 62 | 59 | 17 | 43 | 155 | 0 | 0 | 0 | 0 | 12 | 6 | 9 | 3.42 |
| CL | Chapman, A.Chapman, Aroldis | 38 | Giants | L | 62 | 37 | 0 | 3 | 3 | 2.06 | .281 | 1.17 | 6.4 | 4.1 | 11.1 | 35.0 | 25 | 9 | 8 | 4 | 16 | 43 | 0 | 26 | 1 | 0 | 0 | 0 | 0 | 3.40 |
| CL | Alvarado, J.Alvarado, Jose | 31 | Cubs | L | 89 | 49 | 0 | 6 | 4 | 2.76 | .249 | 0.97 | 6.2 | 2.5 | 9.0 | 78.1 | 54 | 24 | 24 | 3 | 22 | 78 | 0 | 17 | 5 | 0 | 0 | 2 | 1 | 2.42 |