| SP | Rodriguez, E.Rodriguez, Eduardo | 33 | Reds | L | 78 | 30 | 30 | 18 | 8 | 3.40 | .240 | 0.91 | 6.8 | 1.4 | 7.4 | 235.1 | 178 | 90 | 89 | 38 | 36 | 193 | 8 | 0 | 0 | 0 | 18 | 9 | 3 | 4.03 |
| SP | Flaherty, J.Flaherty, Jack # | 30 | Pirates | R | 99 | 31 | 31 | 15 | 7 | 2.69 | .230 | 0.89 | 6.1 | 2.0 | 10.0 | 207.2 | 140 | 64 | 62 | 21 | 45 | 230 | 7 | 0 | 0 | 3 | 20 | 1 | 7 | 2.76 |
| SP | Javier, C.Javier, Cristian | 30 | Cubs | R | 100 | 31 | 31 | 15 | 7 | 3.29 | .274 | 1.09 | 7.4 | 2.4 | 10.1 | 194.0 | 160 | 73 | 71 | 24 | 52 | 217 | 0 | 0 | 0 | 0 | 23 | 8 | 7 | 3.30 |
| SP | Ohtani SP, S.Ohtani SP, Shohei | 32 | Brewers | R | 86 | 31 | 31 | 12 | 13 | 4.37 | .293 | 1.21 | 8.2 | 2.7 | 9.8 | 183.1 | 166 | 92 | 89 | 32 | 55 | 200 | 0 | 0 | 0 | 0 | 15 | 7 | 11 | 4.10 |
| CL | Chapman, A.Chapman, Aroldis | 38 | Giants | L | 62 | 57 | 0 | 3 | 7 | 2.75 | .295 | 1.22 | 6.9 | 4.3 | 11.8 | 55.2 | 42 | 18 | 17 | 6 | 26 | 72 | 0 | 36 | 3 | 0 | 0 | 2 | 2 | 3.33 |
| CL | Alvarado, J.Alvarado, Jose | 31 | Cubs | L | 89 | 65 | 0 | 8 | 5 | 2.68 | .241 | 0.93 | 6.1 | 2.4 | 9.2 | 107.1 | 72 | 32 | 32 | 4 | 28 | 109 | 0 | 20 | 6 | 0 | 0 | 2 | 1 | 2.29 |