| SP | Sabathia, C.Sabathia, CC # | 34 | Cubs | L | 100 | 33 | 33 | 20 | 4 | 3.62 | .286 | 1.18 | 8.5 | 2.2 | 7.7 | 226.1 | 213 | 100 | 91 | 28 | 55 | 194 | 14 | 0 | 0 | 2 | 20 | 4 | 2 | 3.68 |
| SP | Verlander, J.Verlander, Justin # | 31 | Mets | R | 95 | 32 | 32 | 14 | 12 | 3.16 | .273 | 1.10 | 7.7 | 2.2 | 6.8 | 236.2 | 203 | 86 | 83 | 25 | 58 | 177 | 5 | 0 | 0 | 1 | 22 | 5 | 1 | 3.68 |
| SP | Vogelsong, R.Vogelsong, Ryan | 30 | Pirates | R | 97 | 31 | 31 | 15 | 9 | 3.48 | .279 | 1.12 | 8.0 | 2.1 | 7.8 | 225.0 | 201 | 91 | 87 | 29 | 52 | 194 | 11 | 0 | 0 | 2 | 15 | 8 | 0 | 3.75 |
| CL | Tazawa, J.Tazawa, Junichi | 28 | Cardinals | R | 97 | 58 | 0 | 3 | 3 | 2.50 | .263 | 1.04 | 6.6 | 2.8 | 10.9 | 68.1 | 50 | 20 | 19 | 7 | 21 | 82 | 0 | 31 | 1 | 0 | 0 | 2 | 0 | 2.94 |
| CL | Bastardo, A.Bastardo, Antonio | 29 | Dodgers | L | 100 | 55 | 0 | 6 | 6 | 2.81 | .278 | 1.13 | 6.3 | 3.8 | 10.1 | 64.0 | 45 | 20 | 20 | 6 | 27 | 72 | 0 | 29 | 4 | 0 | 0 | 2 | 4 | 3.33 |
| CL | Holland, G.Holland, Greg # | 28 | Nationals | R | 100 | 52 | 0 | 5 | 6 | 4.64 | .338 | 1.51 | 8.5 | 5.2 | 9.3 | 52.1 | 49 | 30 | 27 | 3 | 30 | 54 | 0 | 30 | 9 | 0 | 0 | 1 | 1 | 3.46 |