| SP | Sabathia, C.Sabathia, CC # | 34 | Cubs | L | 100 | 28 | 28 | 18 | 4 | 3.45 | .282 | 1.16 | 8.4 | 2.0 | 7.9 | 198.1 | 185 | 85 | 76 | 24 | 45 | 174 | 12 | 0 | 0 | 2 | 18 | 4 | 2 | 3.56 |
| SP | Verlander, J.Verlander, Justin # | 31 | Mets | R | 95 | 27 | 27 | 13 | 9 | 2.88 | .265 | 1.06 | 7.2 | 2.3 | 7.2 | 200.1 | 161 | 67 | 64 | 16 | 51 | 161 | 3 | 0 | 0 | 1 | 21 | 5 | 1 | 3.27 |
| SP | Vogelsong, R.Vogelsong, Ryan | 30 | Pirates | R | 97 | 25 | 25 | 13 | 6 | 3.05 | .259 | 1.01 | 6.9 | 2.2 | 7.4 | 188.2 | 144 | 67 | 64 | 26 | 46 | 155 | 11 | 0 | 0 | 2 | 14 | 8 | 0 | 4.01 |
| CL | Tazawa, J.Tazawa, Junichi | 28 | Cardinals | R | 97 | 49 | 0 | 2 | 2 | 2.78 | .255 | 1.01 | 6.4 | 2.8 | 10.9 | 58.1 | 41 | 19 | 18 | 6 | 18 | 70 | 0 | 26 | 1 | 0 | 0 | 1 | 0 | 2.91 |
| CL | Bastardo, A.Bastardo, Antonio | 29 | Dodgers | L | 100 | 51 | 0 | 6 | 5 | 2.90 | .275 | 1.10 | 5.9 | 4.0 | 9.8 | 59.0 | 39 | 19 | 19 | 6 | 26 | 64 | 0 | 27 | 4 | 0 | 0 | 2 | 4 | 3.58 |