| SP | Garland, J.Garland, Jon >> | 26 | 2005 | R | 56 | 18 | 10 | 3.50 | .278 | .310 | 1.17 | 8.6 | 1.9 | 4.7 | 221 | 212 | 26 | 47 | 115 | 3 | 0 | 2 | 121 | +4.62 | C |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 100 | 3 | 3 | 1.60 | .157 | .200 | 0.60 | 4.2 | 1.2 | 12.0 | 45 | 21 | 3 | 6 | 60 | 0 | 25 | 1 | 23 | +2.48 | C |
| RP | Reardon, J.Reardon, Jeff >> | 26 | 1981 | R | 91 | 2 | 0 | 1.30 | .184 | .230 | 0.73 | 4.6 | 2.0 | 4.6 | 41 | 21 | 3 | 9 | 21 | 0 | 6 | 1 | 32 | +1.66 | C |
| RP | Hudson, D.Hudson, Daniel >> | 34 | 2021 | R | 94 | 4 | 1 | 2.20 | .221 | .270 | 0.94 | 6.5 | 2.0 | 13.5 | 32 | 23 | 4 | 7 | 48 | 0 | 0 | 1 | 23 | +0.8 | C |
| RP | Valdez, S.Valdez, Sergio >> | 28 | 1992 | R | 88 | 0 | 2 | 2.41 | .234 | .280 | 1.00 | 6.1 | 2.9 | 7.8 | 37 | 25 | 2 | 12 | 32 | 0 | 0 | 4 | 27 | +0.5 | C |
| RP | Storen, D.Storen, Drew >> | 24 | 2012 | R | 84 | 3 | 1 | 2.37 | .231 | .280 | 1.00 | 6.6 | 2.4 | 7.2 | 30 | 22 | 0 | 8 | 24 | 0 | 4 | 1 | 23 | +0.86 | C |
| RP | Nabholz, C.Nabholz, Chris >> | 23 | 1990 | L | 82 | 6 | 2 | 2.83 | .254 | .290 | 1.07 | 5.5 | 4.1 | 6.8 | 70 | 43 | 6 | 32 | 53 | 1 | 0 | 1 | 40 | +1.8 | C |
| RP | Juden, J.Juden, Jeff >> | 25 | 1996 | R | 78 | 1 | 0 | 2.20 | .254 | .300 | 1.13 | 6.2 | 3.9 | 7.3 | 32 | 22 | 1 | 14 | 26 | 0 | 0 | 2 | 29 | +0.54 | C |
| SP | Martinez, P.Martinez, Pedro >> | 26 | 1997 | R | 97 | 17 | 8 | 1.90 | .235 | .270 | 0.93 | 5.9 | 2.5 | 11.4 | 241 | 158 | 16 | 67 | 305 | 13 | 0 | 3 | 136 | +8.99 | C |
| SP | Martinez, D.Martinez, Dennis >> | 37 | 1992 | R | 82 | 16 | 11 | 2.47 | .252 | .290 | 1.03 | 6.8 | 2.4 | 5.9 | 226 | 172 | 12 | 60 | 147 | 6 | 0 | 2 | 124 | +4.68 | C |
| SP | Haren, D.Haren, Dan >> | 25 | 2005 | R | 50 | 14 | 12 | 3.73 | .286 | .320 | 1.22 | 8.8 | 2.2 | 6.8 | 217 | 212 | 26 | 53 | 163 | 3 | 0 | 6 | 112 | +3.31 | C |
| SP | Youmans, F.Youmans, Floyd >> | 22 | 1986 | R | 79 | 13 | 12 | 3.53 | .283 | .320 | 1.20 | 6.0 | 4.8 | 8.3 | 219 | 145 | 14 | 118 | 202 | 6 | 0 | 10 | 117 | +3.69 | C |
| SP | Burnett, A.Burnett, A.J. >> | 28 | 2005 | R | 57 | 12 | 12 | 3.44 | .292 | .330 | 1.26 | 7.9 | 3.4 | 8.5 | 209 | 184 | 12 | 79 | 198 | 4 | 0 | 12 | 115 | +3.4 | C |
| SP | Blanton, J.Blanton, Joe >> | 25 | 2005 | R | 55 | 12 | 12 | 3.53 | .286 | .320 | 1.22 | 8.0 | 3.0 | 5.2 | 201 | 178 | 23 | 67 | 116 | 2 | 0 | 4 | 108 | +3.78 | C |
| SP | McCarthy, B.McCarthy, Brandon >> | 22 | 2005 | R | 60 | 3 | 2 | 4.03 | .272 | .310 | 1.18 | 8.3 | 2.3 | 6.4 | 67 | 62 | 13 | 17 | 48 | 0 | 0 | 1 | 99 | +1.19 | C |
| SP | Schmidt, J.Schmidt, Jason >> | 32 | 2005 | R | 38 | 12 | 7 | 4.40 | .318 | .350 | 1.42 | 8.4 | 4.4 | 8.6 | 172 | 160 | 16 | 85 | 165 | 0 | 0 | 7 | 105 | +1.76 | C |
| SP | Weaver, J.Weaver, Jeff >> | 29 | 2005 | R | 56 | 14 | 11 | 4.22 | .278 | .310 | 1.17 | 8.8 | 1.7 | 6.3 | 224 | 220 | 35 | 43 | 157 | 3 | 0 | 2 | 116 | +1.84 | C |
| SP | Perez, P.Perez, Pascual >> | 31 | 1988 | R | 89 | 12 | 8 | 2.44 | .236 | .270 | 0.94 | 6.4 | 2.1 | 6.3 | 188 | 133 | 15 | 44 | 131 | 4 | 0 | 5 | 122 | +4.48 | C |
| SP | Scherzer, M.Scherzer, Max >> | 33 | 2017 | R | 99 | 16 | 6 | 2.51 | .229 | .260 | 0.91 | 5.7 | 2.5 | 12.1 | 200 | 126 | 22 | 55 | 268 | 2 | 0 | 4 | 114 | +7.18 | C |
| SP | Paige, S.Paige, Satchel >> | 28 | 1934 | R | 98 | 13 | 3 | 1.54 | .222 | .260 | 0.88 | 6.0 | 1.9 | 9.4 | 145 | 97 | 2 | 30 | 152 | 15 | 0 | 0 | 134 | +6.1 | C |
| SP | Contreras, J.Contreras, Jose >> | 34 | 2005 | R | 58 | 15 | 7 | 3.61 | .288 | .320 | 1.24 | 7.8 | 3.3 | 6.8 | 204 | 177 | 23 | 75 | 154 | 1 | 0 | 20 | 112 | +3.59 | C |