| RP | Wisler, M.Wisler, Matt >> | 28 | 2021 | R | 82 | 3 | 5 | 3.70 | .252 | .300 | 1.08 | 7.7 | 2.1 | 11.6 | 48 | 41 | 6 | 11 | 62 | 0 | 1 | 1 | 23 | 22 | C |
| SP | Yarbrough, R.Yarbrough, Ryan >> | 29 | 2021 | L | 52 | 9 | 7 | 5.11 | .286 | .330 | 1.23 | 9.5 | 1.6 | 6.8 | 155 | 163 | 25 | 27 | 117 | 1 | 0 | 1 | 92 | 16 | C |
| RP | Sherriff, R.Sherriff, Ryan >> | 31 | 2021 | L | 32 | 0 | 1 | 5.52 | .307 | .390 | 1.64 | 9.0 | 5.8 | 10.3 | 14 | 14 | 0 | 9 | 16 | 0 | 1 | 2 | 23 | 26 | C |
| RP | Mazza, C.Mazza, Chris >> | 31 | 2021 | R | 57 | 0 | 0 | 4.61 | .266 | .330 | 1.22 | 8.7 | 2.3 | 7.0 | 27 | 26 | 3 | 7 | 21 | 0 | 1 | 3 | 37 | 17 | C |
| SP | Wacha, M.Wacha, Michael >> | 29 | 2021 | R | 40 | 3 | 5 | 5.05 | .299 | .340 | 1.31 | 9.6 | 2.3 | 8.8 | 124 | 132 | 23 | 31 | 121 | 0 | 0 | 5 | 77 | 19 | C |
| RP | Chargois, J.Chargois, J.T. >> | 30 | 2021 | R | 87 | 6 | 1 | 2.52 | .256 | .300 | 1.09 | 6.5 | 3.4 | 9.0 | 53 | 38 | 5 | 20 | 53 | 0 | 0 | 2 | 23 | 20 | C |
| RP | Feyereisen, J.Feyereisen, J.P. >> | 28 | 2021 | R | 78 | 4 | 4 | 2.73 | .279 | .330 | 1.23 | 5.8 | 5.3 | 8.5 | 56 | 36 | 5 | 33 | 53 | 0 | 3 | 3 | 23 | 18 | C |
| RP | Anderson, N.Anderson, Nick >> | 30 | 2021 | R | 86 | 0 | 1 | 4.50 | .176 | .290 | 1.00 | 6.0 | 3.0 | 1.5 | 6 | 4 | 2 | 2 | 1 | 0 | 1 | 0 | 23 | 11 | C |
| RP | Rasmussen, D.Rasmussen, Drew >> | 25 | 2021 | R | 85 | 4 | 1 | 2.84 | .256 | .300 | 1.08 | 6.8 | 3.0 | 8.6 | 76 | 57 | 5 | 25 | 73 | 0 | 1 | 4 | 41 | 19 | C |
| RP | Strickland, H.Strickland, Hunter >> | 32 | 2021 | R | 77 | 3 | 2 | 2.61 | .270 | .320 | 1.17 | 7.1 | 3.4 | 9.0 | 58 | 46 | 8 | 22 | 58 | 0 | 0 | 3 | 23 | 19 | C |
| SP | Fleming, J.Fleming, Josh >> | 25 | 2021 | L | 32 | 10 | 8 | 5.09 | .305 | .350 | 1.36 | 9.5 | 2.7 | 5.6 | 104 | 110 | 11 | 31 | 65 | 0 | 1 | 0 | 72 | 15 | C |
| RP | Archer, C.Archer, Chris >> | 32 | 2021 | R | 55 | 1 | 1 | 4.66 | .280 | .350 | 1.37 | 8.5 | 3.8 | 9.9 | 19 | 18 | 3 | 8 | 21 | 0 | 0 | 1 | 58 | 20 | C |
| RP | Reed, C.Reed, Cody >> | 28 | 2021 | L | 36 | 0 | 1 | 3.72 | .275 | .380 | 1.56 | 8.0 | 6.0 | 7.0 | 9 | 8 | 1 | 6 | 7 | 0 | 0 | 0 | 23 | 17 | C |
| RP | Fairbanks, P.Fairbanks, Peter >> | 27 | 2021 | R | 51 | 3 | 6 | 3.59 | .310 | .360 | 1.45 | 8.6 | 4.5 | 12.0 | 42 | 40 | 2 | 21 | 56 | 0 | 5 | 3 | 23 | 24 | C |
| RP | Conley, A.Conley, Adam >> | 31 | 2021 | R | 84 | 0 | 0 | 2.29 | .230 | .300 | 1.05 | 6.6 | 2.8 | 7.6 | 19 | 14 | 2 | 6 | 16 | 0 | 0 | 0 | 23 | 18 | C |
| RP | Armstrong, S.Armstrong, Shawn >> | 30 | 2021 | R | 38 | 1 | 0 | 6.75 | .314 | .370 | 1.50 | 9.8 | 3.8 | 11.0 | 36 | 39 | 10 | 15 | 44 | 0 | 0 | 0 | 24 | 21 | C |
| RP | Robertson, D.Robertson, David >> | 36 | 2021 | R | 68 | 0 | 0 | 4.50 | .246 | .330 | 1.25 | 8.3 | 3.0 | 12.0 | 12 | 11 | 2 | 4 | 16 | 0 | 0 | 0 | 23 | 26 | C |
| RP | Springs, J.Springs, Jeffrey >> | 28 | 2021 | L | 85 | 5 | 1 | 3.43 | .257 | .310 | 1.11 | 7.2 | 2.9 | 12.9 | 44 | 35 | 9 | 14 | 63 | 0 | 2 | 3 | 23 | 25 | C |