| RP | Lamet, D.Lamet, Dinelson >> | 28 | 2021 | R | 23 | 2 | 4 | 4.40 | .317 | .370 | 1.49 | 9.2 | 4.2 | 10.9 | 47 | 48 | 6 | 22 | 57 | 0 | 0 | 3 | 40 | 21 | C |
| RP | Adams, A.Adams, Austin >> | 30 | 2021 | R | 77 | 3 | 2 | 4.10 | .275 | .330 | 1.21 | 4.8 | 6.1 | 13.2 | 52 | 28 | 1 | 35 | 76 | 0 | 0 | 4 | 23 | 25 | C |
| RP | Melancon, M.Melancon, Mark >> | 36 | 2021 | R | 44 | 4 | 3 | 2.23 | .281 | .330 | 1.23 | 7.6 | 3.5 | 8.3 | 64 | 54 | 4 | 25 | 59 | 0 | 39 | 3 | 23 | 18 | C |
| RP | Stammen, C.Stammen, Craig >> | 37 | 2021 | R | 66 | 6 | 3 | 3.06 | .251 | .300 | 1.05 | 8.1 | 1.3 | 8.5 | 88 | 79 | 13 | 13 | 83 | 0 | 1 | 3 | 26 | 19 | C |
| RP | Hudson, D.Hudson, Daniel >> | 34 | 2021 | R | 89 | 5 | 3 | 3.31 | .256 | .310 | 1.10 | 7.1 | 2.8 | 13.2 | 51 | 40 | 8 | 16 | 75 | 0 | 0 | 3 | 23 | 25 | C |
| RP | Pagan, E.Pagan, Emilio >> | 30 | 2021 | R | 47 | 4 | 3 | 4.83 | .271 | .320 | 1.17 | 8.0 | 2.6 | 9.9 | 63 | 56 | 16 | 18 | 69 | 0 | 0 | 0 | 23 | 19 | C |
| SP | Arrieta, J.Arrieta, Jake >> | 35 | 2021 | R | 3 | 5 | 14 | 7.39 | .365 | .410 | 1.79 | 12.0 | 4.0 | 7.6 | 98 | 131 | 24 | 44 | 83 | 0 | 0 | 3 | 73 | 18 | C |
| SP | Velasquez, V.Velasquez, Vincent >> | 29 | 2021 | R | 21 | 3 | 9 | 6.30 | .324 | .370 | 1.49 | 8.7 | 4.7 | 9.7 | 94 | 91 | 23 | 49 | 101 | 0 | 0 | 2 | 68 | 20 | C |
| SP | Paddack, C.Paddack, Chris >> | 25 | 2021 | R | 27 | 7 | 7 | 5.07 | .291 | .340 | 1.27 | 9.6 | 1.8 | 8.3 | 108 | 115 | 15 | 22 | 99 | 0 | 0 | 2 | 84 | 18 | C |
| RP | Hill, T.Hill, Tim >> | 31 | 2021 | L | 39 | 6 | 6 | 3.62 | .284 | .330 | 1.25 | 7.8 | 3.5 | 8.5 | 59 | 51 | 9 | 23 | 56 | 0 | 1 | 1 | 23 | 19 | C |
| RP | Diaz, M.Diaz, Miguel >> | 26 | 2021 | R | 68 | 3 | 1 | 3.64 | .269 | .320 | 1.19 | 6.6 | 4.1 | 9.9 | 42 | 31 | 8 | 19 | 46 | 0 | 1 | 0 | 33 | 21 | C |
| RP | Johnson, P.Johnson, Pierce >> | 30 | 2021 | R | 54 | 3 | 4 | 3.22 | .287 | .340 | 1.28 | 7.3 | 4.2 | 11.9 | 58 | 47 | 6 | 27 | 77 | 0 | 0 | 6 | 23 | 22 | C |
| RP | Weathers, R.Weathers, Ryan >> | 21 | 2021 | R | 17 | 4 | 7 | 5.32 | .310 | .360 | 1.39 | 9.7 | 2.9 | 6.9 | 94 | 101 | 20 | 30 | 72 | 0 | 1 | 2 | 57 | 17 | C |
| SP | Quantrill, C.Quantrill, Cal >> | 26 | 2021 | R | 73 | 8 | 3 | 2.89 | .278 | .320 | 1.18 | 7.8 | 2.8 | 7.3 | 149 | 129 | 16 | 47 | 121 | 0 | 0 | 3 | 67 | 17 | C |
| RP | Detwiler, R.Detwiler, Ross >> | 35 | 2021 | L | 50 | 3 | 1 | 4.64 | .278 | .330 | 1.23 | 7.6 | 3.5 | 10.7 | 52 | 44 | 10 | 20 | 62 | 0 | 0 | 2 | 23 | 22 | C |
| SP | Snell, B.Snell, Blake >> | 28 | 2021 | L | 53 | 7 | 6 | 4.20 | .301 | .350 | 1.33 | 7.1 | 4.9 | 12.0 | 128 | 101 | 16 | 69 | 170 | 0 | 0 | 7 | 85 | 22 | C |
| RP | Crismatt, N.Crismatt, Nabil >> | 26 | 2021 | R | 20 | 3 | 1 | 3.76 | .305 | .350 | 1.37 | 9.7 | 2.7 | 7.9 | 81 | 87 | 10 | 24 | 71 | 0 | 0 | 3 | 35 | 17 | C |
| SP | Darvish, Y.Darvish, Yu >> | 34 | 2021 | R | 97 | 8 | 11 | 4.22 | .264 | .310 | 1.10 | 7.5 | 2.4 | 10.8 | 166 | 138 | 28 | 44 | 199 | 0 | 0 | 9 | 98 | 21 | C |
| SP | Musgrove, J.Musgrove, Joseph >> | 28 | 2021 | R | 98 | 11 | 9 | 3.18 | .262 | .300 | 1.08 | 7.1 | 2.7 | 10.1 | 181 | 142 | 22 | 54 | 203 | 2 | 0 | 3 | 100 | 20 | C |