| RP | Schooler, M.Schooler, Mike >> | 29 | 1991 | R | 91 | 3 | 3 | 3.67 | .238 | .290 | 1.03 | 6.6 | 2.6 | 8.2 | 34 | 25 | 2 | 10 | 31 | 0 | 7 | 2 | 23 | 20 | C |
| RP | Hernandez, X.Hernandez, Xavier >> | 28 | 1993 | R | 88 | 4 | 5 | 2.61 | .257 | .300 | 1.07 | 7.0 | 2.6 | 9.5 | 96 | 75 | 6 | 28 | 101 | 0 | 9 | 6 | 27 | 20 | C |
| RP | Mayers, M.Mayers, Mike >> | 29 | 2021 | R | 32 | 5 | 5 | 3.84 | .292 | .340 | 1.29 | 8.5 | 3.1 | 10.8 | 75 | 71 | 11 | 26 | 90 | 0 | 2 | 0 | 23 | 21 | C |
| SP | Heaney, A.Heaney, Andrew >> | 30 | 2021 | L | 30 | 8 | 9 | 5.83 | .301 | .350 | 1.33 | 9.1 | 2.9 | 10.5 | 129 | 130 | 29 | 41 | 150 | 0 | 0 | 4 | 77 | 20 | C |
| SP | Ohtani, S.Ohtani, Shohei >> | 26 | 2021 | R | 99 | 9 | 2 | 3.18 | .262 | .310 | 1.09 | 6.8 | 3.0 | 10.8 | 130 | 98 | 15 | 44 | 156 | 0 | 0 | 10 | 100 | 21 | C |
| SP | Canning, G.Canning, Griffin >> | 25 | 2021 | R | 16 | 5 | 4 | 5.60 | .322 | .370 | 1.50 | 9.4 | 4.1 | 9.0 | 62 | 65 | 14 | 28 | 62 | 0 | 0 | 3 | 79 | 20 | C |
| SP | Sandoval, P.Sandoval, Patrick >> | 24 | 2021 | L | 91 | 3 | 6 | 3.62 | .279 | .330 | 1.21 | 7.1 | 3.7 | 9.7 | 87 | 69 | 11 | 36 | 94 | 0 | 1 | 3 | 91 | 20 | C |
| RP | Percival, T.Percival, Troy >> | 26 | 1995 | R | 100 | 3 | 2 | 1.95 | .214 | .260 | 0.85 | 4.5 | 3.2 | 11.4 | 74 | 37 | 6 | 26 | 94 | 0 | 3 | 2 | 24 | 21 | C |
| SP | Gullickson, B.Gullickson, Bill >> | 22 | 1981 | R | 67 | 7 | 9 | 2.80 | .268 | .310 | 1.12 | 8.1 | 1.9 | 6.6 | 157 | 142 | 3 | 34 | 115 | 3 | 0 | 4 | 125 | 16 | C |
| RP | Service, S.Service, Scott >> | 28 | 1995 | R | 64 | 3 | 1 | 3.19 | .270 | .330 | 1.23 | 5.2 | 5.8 | 8.7 | 31 | 18 | 4 | 20 | 30 | 0 | 0 | 3 | 23 | 20 | C |
| SP | Ohtani, S.Ohtani, Shohei >> | 26 | 2021 | R | 98 | 9 | 2 | 3.18 | .262 | .310 | 1.09 | 6.8 | 3.0 | 10.8 | 130 | 98 | 15 | 44 | 156 | 0 | 0 | 10 | 100 | 21 | C |
| RP | Cishek, S.Cishek, Steven >> | 35 | 2021 | R | 22 | 0 | 2 | 3.42 | .323 | .370 | 1.50 | 8.1 | 5.4 | 8.5 | 68 | 61 | 2 | 41 | 64 | 0 | 0 | 4 | 23 | 19 | C |
| SP | Fernandez, A.Fernandez, Alex >> | 28 | 1997 | R | 65 | 17 | 12 | 3.59 | .281 | .320 | 1.19 | 7.9 | 2.8 | 7.5 | 220 | 193 | 25 | 69 | 183 | 5 | 0 | 9 | 121 | 17 | C |
| SP | Cobb, A.Cobb, Alex >> | 33 | 2021 | R | 36 | 8 | 3 | 3.76 | .290 | .340 | 1.27 | 8.2 | 3.2 | 9.5 | 93 | 85 | 5 | 33 | 98 | 0 | 0 | 4 | 92 | 19 | C |
| SP | Suarez, J.Suarez, Jose >> | 23 | 2021 | L | 46 | 8 | 8 | 3.75 | .285 | .330 | 1.23 | 7.8 | 3.3 | 7.8 | 98 | 85 | 11 | 36 | 85 | 1 | 0 | 4 | 76 | 18 | C |
| SP | Barria, J.Barria, Jaime >> | 24 | 2021 | R | 5 | 2 | 4 | 4.61 | .333 | .390 | 1.59 | 11.3 | 3.1 | 5.6 | 56 | 70 | 8 | 19 | 35 | 0 | 0 | 0 | 77 | 15 | C |
| RP | Quintana, J.Quintana, Jose >> | 32 | 2021 | L | 12 | 0 | 3 | 6.43 | .354 | .400 | 1.73 | 10.6 | 5.0 | 12.1 | 63 | 74 | 12 | 35 | 85 | 0 | 0 | 7 | 41 | 22 | C |
| RP | Watson, T.Watson, Tony >> | 36 | 2021 | L | 91 | 7 | 4 | 3.92 | .243 | .290 | 1.02 | 6.3 | 2.8 | 6.9 | 57 | 40 | 4 | 18 | 44 | 0 | 0 | 0 | 23 | 17 | C |
| SP | Ryan, N.Ryan, Nolan >> | 25 | 1972 | R | 97 | 19 | 16 | 2.28 | .273 | .310 | 1.14 | 5.3 | 5.0 | 10.4 | 284 | 166 | 14 | 157 | 329 | 20 | 0 | 18 | 128 | 20 | C |
| RP | Strickland, H.Strickland, Hunter >> | 32 | 2021 | R | 60 | 3 | 2 | 2.61 | .270 | .320 | 1.17 | 7.1 | 3.4 | 9.0 | 58 | 46 | 8 | 22 | 58 | 0 | 0 | 3 | 23 | 19 | C |
| RP | Frieri, E.Frieri, Ernesto >> | 26 | 2012 | R | 99 | 5 | 2 | 2.32 | .238 | .290 | 0.98 | 4.8 | 4.1 | 13.4 | 66 | 35 | 9 | 30 | 98 | 0 | 23 | 1 | 23 | 24 | C |
| RP | Iglesias, R.Iglesias, Raisel >> | 31 | 2021 | R | 97 | 7 | 5 | 2.57 | .228 | .280 | 0.93 | 6.8 | 1.5 | 13.2 | 70 | 53 | 11 | 12 | 103 | 0 | 34 | 2 | 23 | 24 | C |
| RP | Guerra, J.Guerra, Junior >> | 36 | 2021 | R | 8 | 5 | 2 | 6.06 | .355 | .410 | 1.74 | 9.3 | 6.4 | 8.4 | 65 | 67 | 6 | 46 | 61 | 0 | 0 | 9 | 31 | 18 | C |
| RP | Robinson, D.Robinson, Don >> | 27 | 1984 | R | 52 | 5 | 6 | 3.02 | .282 | .330 | 1.21 | 7.3 | 3.6 | 8.1 | 122 | 99 | 6 | 49 | 110 | 0 | 10 | 5 | 45 | 18 | C |
| SP | Bundy, D.Bundy, Dylan >> | 29 | 2021 | R | 23 | 2 | 9 | 6.06 | .305 | .350 | 1.37 | 8.9 | 3.4 | 8.4 | 90 | 89 | 20 | 34 | 84 | 0 | 0 | 1 | 71 | 18 | C |
| RP | Perez, M.Perez, Melido >> | 25 | 1991 | R | 52 | 8 | 7 | 3.12 | .282 | .330 | 1.21 | 7.4 | 3.5 | 8.5 | 135 | 111 | 15 | 52 | 128 | 0 | 1 | 11 | 51 | 18 | C |
| RP | Harris, G.Harris, Greg >> | 26 | 1989 | R | 58 | 8 | 9 | 2.60 | .276 | .320 | 1.17 | 7.1 | 3.5 | 7.1 | 135 | 106 | 8 | 52 | 106 | 0 | 6 | 3 | 45 | 17 | C |