| C(1B) | Martinez, V.Martinez, Victor >> | 32 | 2010 | S | 56 | 54 | 69 | 127 | .302 | .355 | .493 | .848 | .290 | 493 | 64 | 149 | 32 | 1 | 20 | 79 | 40 | 52 | 0 | 1 | .991 | - | +0.26 | 2 | 12 | 7 | C |
| C(1B) | Mauer, J.Mauer, Joe >> | 27 | 2010 | L | 94 | 83 | 93 | 137 | .327 | .407 | .469 | .876 | .350 | 510 | 88 | 167 | 43 | 1 | 9 | 75 | 65 | 53 | 3 | 1 | .996 | - | +0.92 | 2 | 8 | 8 | C |
| 1B(DH) | Morneau, J.Morneau, Justin >> | 29 | 2010 | L | 100 | 99 | 82 | 81 | .345 | .439 | .618 | 1.057 | .380 | 296 | 53 | 102 | 25 | 1 | 18 | 56 | 50 | 62 | 0 | 0 | .999 | - | +0.39 | 2 | 16 | 5 | C |
| 1B(3B) | Youkilis, K.Youkilis, Kevin >> | 31 | 2010 | R | 93 | 87 | 72 | 102 | .307 | .416 | .564 | .980 | .360 | 362 | 77 | 111 | 26 | 5 | 19 | 62 | 58 | 67 | 10 | 4 | .997 | - | +0.09 | 5 | 13 | 6 | C |
| 1B(DH) | Konerko, P.Konerko, Paul >> | 34 | 2010 | R | 75 | 85 | 20 | 149 | .312 | .397 | .584 | .981 | .340 | 548 | 89 | 171 | 30 | 1 | 39 | 111 | 72 | 110 | 5 | 0 | .994 | - | -2.28 | 2 | 14 | 14 | C |
| 1B(DH) | Cabrera, M.Cabrera, Miguel >> | 27 | 2010 | R | 88 | 97 | 19 | 150 | .328 | .425 | .622 | 1.047 | .360 | 548 | 111 | 180 | 45 | 1 | 38 | 126 | 89 | 95 | 3 | 3 | .990 | - | -1.37 | 2 | 14 | 16 | C |
| 2B(IF) | Cano, R.Cano, Robinson >> | 28 | 2010 | L | 90 | 78 | 100 | 160 | .319 | .384 | .534 | .918 | .320 | 626 | 103 | 200 | 41 | 3 | 29 | 109 | 57 | 77 | 8 | 3 | .996 | - | +2.16 | 3 | 11 | 83 | C |
| 2B(IF) | Pedroia, D.Pedroia, Dustin >> | 27 | 2010 | R | 66 | 57 | 81 | 75 | .288 | .373 | .493 | .866 | .310 | 302 | 53 | 87 | 24 | 1 | 12 | 41 | 37 | 38 | 4 | 9 | .991 | - | +0.76 | 5 | 11 | 5 | C |
| 3B(IF) | Beltre, A.Beltre, Adrian >> | 31 | 2010 | R | 77 | 74 | 74 | 154 | .321 | .369 | .553 | .922 | .310 | 589 | 84 | 189 | 49 | 2 | 28 | 102 | 40 | 82 | 5 | 2 | .957 | - | +2.37 | 2 | 12 | 22 | C |
| 3B(IF) | Longoria, E.Longoria, Evan >> | 25 | 2010 | R | 71 | 63 | 77 | 151 | .294 | .378 | .507 | .885 | .320 | 574 | 96 | 169 | 46 | 5 | 22 | 104 | 72 | 124 | 5 | 15 | .966 | - | +2.47 | 5 | 11 | 17 | C |
| SS(IF) | Gonzalez, A.Gonzalez, Alex >> | 33 | 2010 | R | 21 | 13 | 86 | 157 | .250 | .295 | .447 | .742 | .240 | 595 | 74 | 149 | 42 | 3 | 23 | 88 | 31 | 118 | 7 | 1 | .973 | - | +3.72 | 2 | 11 | 34 | C |
| SS(IF) | Ramirez, A.Ramirez, Alexei >> | 29 | 2010 | R | 28 | 25 | 84 | 156 | .282 | .316 | .431 | .747 | .260 | 585 | 83 | 165 | 29 | 2 | 18 | 70 | 27 | 82 | 2 | 13 | .974 | - | +3.01 | 4 | 10 | 29 | C |
| OF(OF) | Gardner, B.Gardner, Brett >> | 27 | 2010 | L | 65 | 43 | 100 | 150 | .277 | .385 | .379 | .764 | .320 | 477 | 97 | 132 | 20 | 7 | 5 | 47 | 79 | 101 | 5 | 47 | .997 | - | +3.34 | 9 | 8 | 16 | C |
| OF(OF) | Cruz, N.Cruz, Nelson >> | 30 | 2010 | R | 72 | 80 | 35 | 108 | .318 | .379 | .576 | .955 | .320 | 399 | 60 | 127 | 31 | 3 | 22 | 78 | 38 | 81 | 1 | 17 | .981 | - | -0.14 | 6 | 14 | 6 | C |
| OF(OF) | Crawford, C.Crawford, Carl >> | 29 | 2010 | L | 61 | 59 | 72 | 154 | .307 | .359 | .495 | .854 | .300 | 600 | 110 | 184 | 30 | 13 | 19 | 90 | 46 | 104 | 3 | 47 | .994 | - | +0.26 | 8 | 10 | 22 | C |
| OF(OF) | Choo, S.Choo, Shin-Soo >> | 28 | 2010 | L | 74 | 72 | 45 | 144 | .300 | .402 | .484 | .886 | .340 | 550 | 81 | 165 | 31 | 2 | 22 | 90 | 83 | 118 | 11 | 22 | .986 | - | -0.05 | 5 | 11 | 11 | C |
| OF(OF) | Hamilton, J.Hamilton, Josh >> | 29 | 2010 | L | 99 | 98 | 72 | 133 | .359 | .413 | .633 | 1.046 | .350 | 518 | 95 | 186 | 40 | 3 | 32 | 100 | 43 | 95 | 5 | 8 | .985 | - | +0.77 | 4 | 13 | 8 | C |
| OF(1B) | Swisher, N.Swisher, Nick >> | 30 | 2010 | S | 43 | 51 | 25 | 150 | .288 | .360 | .511 | .871 | .300 | 566 | 91 | 163 | 33 | 3 | 29 | 89 | 58 | 139 | 6 | 1 | .987 | - | -0.77 | 2 | 12 | 16 | C |
| OF(3B) | Bautista, J.Bautista, Jose >> | 30 | 2010 | R | 53 | 61 | 18 | 161 | .260 | .380 | .617 | .997 | .320 | 569 | 109 | 148 | 35 | 3 | 54 | 124 | 100 | 116 | 10 | 9 | .980 | + | -0.69 | 4 | 17 | 164 | C |